Heart failure in systemic right ventricle: Mechanisms and therapeutic options
d-loop transposition of the great arteries (d-TGA) and congenitally corrected transposition of the great arteries (cc-TGA) feature a right ventricle attempting to sustain the systemic circulation. A systemic right ventricle (sRV) cannot support cardiac output in the long run, eventually decompensati...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-01-01
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| Series: | Frontiers in Cardiovascular Medicine |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcvm.2022.1064196/full |
| _version_ | 1797956484136435712 |
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| author | Belal Nedal Sabbah Tarek Ziad Arabi Areez Shafqat Saleha Abdul Rab Adhil Razak Dimpna Calila Albert-Brotons |
| author_facet | Belal Nedal Sabbah Tarek Ziad Arabi Areez Shafqat Saleha Abdul Rab Adhil Razak Dimpna Calila Albert-Brotons |
| author_sort | Belal Nedal Sabbah |
| collection | DOAJ |
| description | d-loop transposition of the great arteries (d-TGA) and congenitally corrected transposition of the great arteries (cc-TGA) feature a right ventricle attempting to sustain the systemic circulation. A systemic right ventricle (sRV) cannot support cardiac output in the long run, eventually decompensating and causing heart failure. The burden of d-TGA patients with previous atrial switch repair and cc-TGA patients with heart failure will only increase in the coming years due to the aging adult congenital heart disease population and improvements in the management of advanced heart failure. Clinical data still lags behind in developing evidence-based guidelines for risk stratification and management of sRV patients, and clinical trials for heart failure in these patients are underrepresented. Recent studies have provided foundational data for the commencement of robust clinical trials in d-TGA and cc-TGA patients. Further insights into the multifactorial nature of sRV failure can only be provided by the results of such studies. This review discusses the mechanisms of heart failure in sRV patients with biventricular circulation and how these mediators may be targeted clinically to alleviate sRV failure. |
| first_indexed | 2024-04-10T23:50:42Z |
| format | Article |
| id | doaj.art-e075fffaf30c4adc8161c3393a2208e3 |
| institution | Directory Open Access Journal |
| issn | 2297-055X |
| language | English |
| last_indexed | 2024-04-10T23:50:42Z |
| publishDate | 2023-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cardiovascular Medicine |
| spelling | doaj.art-e075fffaf30c4adc8161c3393a2208e32023-01-10T20:02:26ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2023-01-01910.3389/fcvm.2022.10641961064196Heart failure in systemic right ventricle: Mechanisms and therapeutic optionsBelal Nedal Sabbah0Tarek Ziad Arabi1Areez Shafqat2Saleha Abdul Rab3Adhil Razak4Dimpna Calila Albert-Brotons5College of Medicine, Alfaisal University, Riyadh, Saudi ArabiaCollege of Medicine, Alfaisal University, Riyadh, Saudi ArabiaCollege of Medicine, Alfaisal University, Riyadh, Saudi ArabiaCollege of Medicine, Alfaisal University, Riyadh, Saudi ArabiaCollege of Medicine, Alfaisal University, Riyadh, Saudi ArabiaDepartment of Pediatric Cardiology, Pediatric Heart Failure and Heart Transplant, Heart Center, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabiad-loop transposition of the great arteries (d-TGA) and congenitally corrected transposition of the great arteries (cc-TGA) feature a right ventricle attempting to sustain the systemic circulation. A systemic right ventricle (sRV) cannot support cardiac output in the long run, eventually decompensating and causing heart failure. The burden of d-TGA patients with previous atrial switch repair and cc-TGA patients with heart failure will only increase in the coming years due to the aging adult congenital heart disease population and improvements in the management of advanced heart failure. Clinical data still lags behind in developing evidence-based guidelines for risk stratification and management of sRV patients, and clinical trials for heart failure in these patients are underrepresented. Recent studies have provided foundational data for the commencement of robust clinical trials in d-TGA and cc-TGA patients. Further insights into the multifactorial nature of sRV failure can only be provided by the results of such studies. This review discusses the mechanisms of heart failure in sRV patients with biventricular circulation and how these mediators may be targeted clinically to alleviate sRV failure.https://www.frontiersin.org/articles/10.3389/fcvm.2022.1064196/fullsystemic right ventricleheart failuredextro-transposition of the great arteriescongenitally corrected transposition of the great arteriesatrial switch repairtricuspid regurgitation |
| spellingShingle | Belal Nedal Sabbah Tarek Ziad Arabi Areez Shafqat Saleha Abdul Rab Adhil Razak Dimpna Calila Albert-Brotons Heart failure in systemic right ventricle: Mechanisms and therapeutic options Frontiers in Cardiovascular Medicine systemic right ventricle heart failure dextro-transposition of the great arteries congenitally corrected transposition of the great arteries atrial switch repair tricuspid regurgitation |
| title | Heart failure in systemic right ventricle: Mechanisms and therapeutic options |
| title_full | Heart failure in systemic right ventricle: Mechanisms and therapeutic options |
| title_fullStr | Heart failure in systemic right ventricle: Mechanisms and therapeutic options |
| title_full_unstemmed | Heart failure in systemic right ventricle: Mechanisms and therapeutic options |
| title_short | Heart failure in systemic right ventricle: Mechanisms and therapeutic options |
| title_sort | heart failure in systemic right ventricle mechanisms and therapeutic options |
| topic | systemic right ventricle heart failure dextro-transposition of the great arteries congenitally corrected transposition of the great arteries atrial switch repair tricuspid regurgitation |
| url | https://www.frontiersin.org/articles/10.3389/fcvm.2022.1064196/full |
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