Human papillomaviruses activate the ATM DNA damage pathway for viral genome amplification upon differentiation.

Human papillomaviruses activate the ATM DNA damage pathway for viral genome amplification upon differentiation.

Human papillomaviruses (HPV) are the causative agents of cervical cancers. The infectious HPV life cycle is closely linked to the differentiation state of the host epithelia, with viral genome amplification, late gene expression and virion production restricted to suprabasal cells. The E6 and E7 pro...

Full description

Bibliographic Details
Main Authors:	Cary A Moody, Laimonis A Laimins
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2009-10-01
Series:	PLoS Pathogens
Online Access:	http://europepmc.org/articles/PMC2745661?pdf=render

Similar Items

The JAK-STAT transcriptional regulator, STAT-5, activates the ATM DNA damage pathway to induce HPV 31 genome amplification upon epithelial differentiation.
by: Shiyuan Hong, et al.
Published: (2013-01-01)

Human Papillomaviruses Preferentially Recruit DNA Repair Factors to Viral Genomes for Rapid Repair and Amplification
by: Kavi Mehta, et al.
Published: (2018-03-01)

Human Papillomavirus and the DNA Damage Response: Exploiting Host Repair Pathways for Viral Replication
by: Chelsey C. Spriggs, et al.
Published: (2017-08-01)

Genomic Instability and DNA Damage Repair Pathways Induced by Human Papillomaviruses
by: Takeyuki Kono, et al.
Published: (2021-09-01)

Regulation of the Human Papillomavirus Life Cycle by DNA Damage Repair Pathways and Epigenetic Factors
by: Ekaterina Albert, et al.
Published: (2020-07-01)

Human Papillomaviruses Target the DNA Damage Repair and Innate Immune Response Pathways to Allow for Persistent Infection
by: Elona Gusho, et al.
Published: (2021-07-01)

FANCD2 Binds Human Papillomavirus Genomes and Associates with a Distinct Set of DNA Repair Proteins to Regulate Viral Replication
by: Chelsey C. Spriggs, et al.
Published: (2017-03-01)

Human papillomaviruses sensitize cells to DNA damage induced apoptosis by targeting the innate immune sensor cGAS.
by: Elona Gusho, et al.
Published: (2022-07-01)

Post-Transcriptional Regulation of KLF4 by High-Risk Human Papillomaviruses Is Necessary for the Differentiation-Dependent Viral Life Cycle.
by: Vignesh Kumar Gunasekharan, et al.
Published: (2016-07-01)

Pathogenesis of Human Papillomaviruses Requires the ATR/p62 Autophagy-Related Pathway
by: Shiyuan Hong, et al.
Published: (2020-08-01)

Human papillomaviruses activate and recruit SMC1 cohesin proteins for the differentiation-dependent life cycle through association with CTCF insulators.
by: Kavi Mehta, et al.
Published: (2015-04-01)

STAT-5 Regulates Transcription of the Topoisomerase IIβ-Binding Protein 1 (TopBP1) Gene To Activate the ATR Pathway and Promote Human Papillomavirus Replication
by: Shiyuan Hong, et al.
Published: (2015-12-01)

ATM induces MacroD2 nuclear export upon DNA damage.
by: Golia, B, et al.
Published: (2016)

ATM and ATR Expression Potentiates HBV Replication and Contributes to Reactivation of HBV Infection upon DNA Damage
by: Anastasiya Kostyusheva, et al.
Published: (2019-10-01)

The DNA damage sensor ATM kinase interacts with the p53 mRNA and guides the DNA damage response pathway
by: Konstantinos Karakostis, et al.
Published: (2024-01-01)

ATM, ATR, and DNA-PK: The trinity at the heart of the DNA damage response
by: Blackford, A, et al.
Published: (2017)

Regulation of the Innate Immune Response during the Human Papillomavirus Life Cycle
by: Cary A. Moody
Published: (2022-08-01)

Epigenetic Regulation of the Human Papillomavirus Life Cycle
by: Michelle Mac, et al.
Published: (2020-06-01)

Mechanisms regulating expression of the HPV 31 L1 and L2 capsid proteins and pseudovirion entry
by: Hindmarsh Patrick L, et al.
Published: (2007-02-01)

DNA-Damage-Induced Nuclear Export of Precursor MicroRNAs Is Regulated by the ATM-AKT Pathway
by: Guohui Wan, et al.
Published: (2013-06-01)

Interplay between the DNA damage response and the life cycle of DNA tumor viruses
by: Caleb J. Studstill, et al.
Published: (2023-12-01)

Down-regulation of HtrA1 activates the epithelial-mesenchymal transition and ATM DNA damage response pathways.
by: Ning Wang, et al.
Published: (2012-01-01)

ATM Dependent Silencing Links Nucleolar Chromatin Reorganization to DNA Damage Recognition
by: Shane M. Harding, et al.
Published: (2015-10-01)

Reverse engineering of drug induced DNA damage response signalling pathway reveals dual outcomes of ATM kinase inhibition
by: Michael A. Idowu, et al.
Published: (2013-12-01)

Myc Is Required for Activation of the ATM-Dependent Checkpoints in Response to DNA Damage
by: Guerra, Lina, et al.
Published: (2010)

Myc is required for activation of the ATM-dependent checkpoints in response to DNA damage.
by: Lina Guerra, et al.
Published: (2010-01-01)

Cyclin D1 Binding Protein 1 Responds to DNA Damage through the ATM–CHK2 Pathway
by: Yusuke Niwa, et al.
Published: (2022-02-01)

Ribosomal S6 Kinase 2 (RSK2) maintains genomic stability by activating the Atm/p53-dependent DNA damage pathway.
by: Han Chi Lim, et al.
Published: (2013-01-01)

Productive lifecycle of human papillomaviruses that depends upon squamous epithelial differentiation.
by: Naoko eKajitani, et al.
Published: (2012-04-01)

ATM: Main Features, Signaling Pathways, and Its Diverse Roles in DNA Damage Response, Tumor Suppression, and Cancer Development
by: Liem Minh Phan, et al.
Published: (2021-05-01)

ATM regulates a RASSF1A-dependent DNA damage response.
by: Hamilton, G, et al.
Published: (2009)

Phosphorylation of Daxx by ATM contributes to DNA damage-induced p53 activation.
by: Jun Tang, et al.
Published: (2013-01-01)

DNA damage activates the SAC in an ATM/ATR-dependent manner, independently of the kinetochore.
by: Eun Mi Kim, et al.
Published: (2008-02-01)

High Fidelity Deep Sequencing Reveals No Effect of ATM, ATR, and DNA-PK Cellular DNA Damage Response Pathways on Adenovirus Mutation Rate
by: Jennifer Risso-Ballester, et al.
Published: (2019-10-01)

Brd4 Activates Early Viral Transcription upon Human Papillomavirus 18 Infection of Primary Keratinocytes
by: Caleb C. McKinney, et al.
Published: (2016-12-01)

TRIP13 Participates in Immediate-Early Sensing of DNA Strand Breaks and ATM Signaling Amplification through MRE11
by: Hyeongsun Jeong, et al.
Published: (2022-12-01)

Targeting ATM-deficient CLL through interference with DNA repair pathways
by: Gero eKnittel, et al.
Published: (2015-06-01)

Human papillomavirus type 13: Genome amplification and characterization data
by: Nuvia Kantún-Moreno, et al.
Published: (2021-04-01)

The Role of the DNA Damage Response throughout the Papillomavirus Life Cycle
by: Caleb C. McKinney, et al.
Published: (2015-05-01)

Effects of Caffeine, a DNA Damage Response Inhibitor, on Papillomavirus Genome Replication
by: Sriramana Kanginakudru, et al.
Published: (2022-11-01)