Mechanism associated with changes in male reproductive functions during ageing process
Ageing is a natural process with physiological changes in different body parts and has been associated with decreased reproductive capacity. Factors such as imbalance in the antioxidant defence system, vascular diseases, diabetes mellitus, accessory reproductive glands infection, obesity as well as...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-08-01
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| Series: | Experimental Gerontology |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0531556523001535 |
| _version_ | 1797774847523160064 |
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| author | Ayodeji Folorunsho Ajayi Moyinoluwa Comfort Onaolapo Ayomide Isaac Omole Wale Johnson Adeyemi David Tolulope Oluwole |
| author_facet | Ayodeji Folorunsho Ajayi Moyinoluwa Comfort Onaolapo Ayomide Isaac Omole Wale Johnson Adeyemi David Tolulope Oluwole |
| author_sort | Ayodeji Folorunsho Ajayi |
| collection | DOAJ |
| description | Ageing is a natural process with physiological changes in different body parts and has been associated with decreased reproductive capacity. Factors such as imbalance in the antioxidant defence system, vascular diseases, diabetes mellitus, accessory reproductive glands infection, obesity as well as buildup of toxic substances play a role in age-related male reproductive malfunction.Age is inversely proportional to volume of semen, sperm count, sperm progressive motility, sperm viability, normal sperm morphology. The observed negative correlation between ageing and semen indices contributes to male infertility and reproductive decline. Normal levels of ROS, plays crucial role in facilitating sperm function, such as capacitation, hyper-activation, acrosome reaction as well as sperm–oocyte fusion; however, a substantial elevation in the endogenous level of ROS, especially in reproductive tissues, usually instigates destruction of sperm cells and heightened male infertility. Contrarily, antioxidants, such as vitamins C and E, beta-carotene, and micronutrients like zinc and folate, have been found by researchers to facilitate normal semen quality and male reproductive function.Furthermore, the role of hormonal imbalance as a result of the compromised hypothalamic-pituitary-gonadal axis, Sertoli and Leydig cells disorder, and nitric oxide-medicated erectile dysfunction during ageing cannot be undermined. |
| first_indexed | 2024-03-12T22:27:10Z |
| format | Article |
| id | doaj.art-e077fedac4044e8aa3750ac3c1d6bbc8 |
| institution | Directory Open Access Journal |
| issn | 1873-6815 |
| language | English |
| last_indexed | 2024-03-12T22:27:10Z |
| publishDate | 2023-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Experimental Gerontology |
| spelling | doaj.art-e077fedac4044e8aa3750ac3c1d6bbc82023-07-22T04:51:17ZengElsevierExperimental Gerontology1873-68152023-08-01179112232Mechanism associated with changes in male reproductive functions during ageing processAyodeji Folorunsho Ajayi0Moyinoluwa Comfort Onaolapo1Ayomide Isaac Omole2Wale Johnson Adeyemi3David Tolulope Oluwole4Department of Physiology, Ladoke Akintola University of Technology, Ogbomoso, Oyo State, Nigeria; Anchor Biomed Research Institute, Ogbomoso, Oyo State, Nigeria; Corresponding author at: Department of Physiology, Ladoke Akintola University of Technology, Ogbomoso, Oyo State, Nigeria.Department of Physiology, Ladoke Akintola University of Technology, Ogbomoso, Oyo State, NigeriaDepartment of Physiology, Ladoke Akintola University of Technology, Ogbomoso, Oyo State, NigeriaDepartment of Physiology, Adeleke University, Ede, Osun-State, NigeriaDepartment of Physiology, Ladoke Akintola University of Technology, Ogbomoso, Oyo State, Nigeria; Department of Physiology, Crescent University, Abeokuta, Ogun-State, NigeriaAgeing is a natural process with physiological changes in different body parts and has been associated with decreased reproductive capacity. Factors such as imbalance in the antioxidant defence system, vascular diseases, diabetes mellitus, accessory reproductive glands infection, obesity as well as buildup of toxic substances play a role in age-related male reproductive malfunction.Age is inversely proportional to volume of semen, sperm count, sperm progressive motility, sperm viability, normal sperm morphology. The observed negative correlation between ageing and semen indices contributes to male infertility and reproductive decline. Normal levels of ROS, plays crucial role in facilitating sperm function, such as capacitation, hyper-activation, acrosome reaction as well as sperm–oocyte fusion; however, a substantial elevation in the endogenous level of ROS, especially in reproductive tissues, usually instigates destruction of sperm cells and heightened male infertility. Contrarily, antioxidants, such as vitamins C and E, beta-carotene, and micronutrients like zinc and folate, have been found by researchers to facilitate normal semen quality and male reproductive function.Furthermore, the role of hormonal imbalance as a result of the compromised hypothalamic-pituitary-gonadal axis, Sertoli and Leydig cells disorder, and nitric oxide-medicated erectile dysfunction during ageing cannot be undermined.http://www.sciencedirect.com/science/article/pii/S0531556523001535AgeingSpermOxidative stressAntioxidantMale reproduction |
| spellingShingle | Ayodeji Folorunsho Ajayi Moyinoluwa Comfort Onaolapo Ayomide Isaac Omole Wale Johnson Adeyemi David Tolulope Oluwole Mechanism associated with changes in male reproductive functions during ageing process Experimental Gerontology Ageing Sperm Oxidative stress Antioxidant Male reproduction |
| title | Mechanism associated with changes in male reproductive functions during ageing process |
| title_full | Mechanism associated with changes in male reproductive functions during ageing process |
| title_fullStr | Mechanism associated with changes in male reproductive functions during ageing process |
| title_full_unstemmed | Mechanism associated with changes in male reproductive functions during ageing process |
| title_short | Mechanism associated with changes in male reproductive functions during ageing process |
| title_sort | mechanism associated with changes in male reproductive functions during ageing process |
| topic | Ageing Sperm Oxidative stress Antioxidant Male reproduction |
| url | http://www.sciencedirect.com/science/article/pii/S0531556523001535 |
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