Molecular Mechanisms of the Genetic Predisposition to Acute Megakaryoblastic Leukemia in Infants With Down Syndrome

Molecular Mechanisms of the Genetic Predisposition to Acute Megakaryoblastic Leukemia in Infants With Down Syndrome

Individuals with Down syndrome are genetically predisposed to developing acute megakaryoblastic leukemia. This myeloid leukemia associated with Down syndrome (ML–DS) demonstrates a model of step-wise leukemogenesis with perturbed hematopoiesis already presenting in utero, facilitating the acquisitio...

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Bibliographic Details
Main Authors: Juliane Grimm, Dirk Heckl, Jan-Henning Klusmann
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Oncology
Subjects:
ML–DS
transient myeloproliferative disorder of Down syndrome
TAM
genetic predisposition
Trisomy 21 (Down syndrome)
acute myeloid leukemia
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2021.636633/full

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