Collision Enhanced Raman Scattering (CERS): An Ultra-High Efficient Raman Enhancement Technique for Hollow Core Photonic Crystal Fiber Based Raman Spectroscopy Gas Analyzer
Raman enhancement techniques are essential for gas analysis to increase the detection sensitivity of a Raman spectroscopy system. We have developed an efficient Raman enhancement technique called the collision-enhanced Raman scattering (CERS), where the active Raman gas as the analyte is mixed with...
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| Format: | Article |
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MDPI AG
2023-11-01
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| Series: | Biosensors |
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| Online Access: | https://www.mdpi.com/2079-6374/13/11/979 |
| _version_ | 1797460007076233216 |
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| author | Maryam Shirmohammad Michael A. Short Haishan Zeng |
| author_facet | Maryam Shirmohammad Michael A. Short Haishan Zeng |
| author_sort | Maryam Shirmohammad |
| collection | DOAJ |
| description | Raman enhancement techniques are essential for gas analysis to increase the detection sensitivity of a Raman spectroscopy system. We have developed an efficient Raman enhancement technique called the collision-enhanced Raman scattering (CERS), where the active Raman gas as the analyte is mixed with a buffer gas inside the hollow-core photonic-crystal fiber (HCPCF) of a fiber-enhanced Raman spectroscopy (FERS) system. This results in an enhanced Raman signal from the analyte gas. In this study, we first showed that the intensity of the 587 cm<sup>−1</sup> stimulated Raman scattering (SRS) peak of H<sub>2</sub> confined in an HCPCF is enhanced by as much as five orders of magnitude by mixing with a buffer gas such as helium or N<sub>2</sub>. Secondly, we showed that the magnitudes of Raman enhancement depend on the type of buffer gas, with helium being more efficient compared to N<sub>2</sub>. This makes helium a favorable buffer gas for CERS. Thirdly, we applied CERS for Raman measurements of propene, a metabolically interesting volatile organic compound (VOC) with an association to lung cancer. CERS resulted in a substantial enhancement of propene Raman peaks. In conclusion, the CERS we developed is a simple and efficient Raman-enhancing mechanism for improving gas analysis. It has great potential for application in breath analysis for lung cancer detection. |
| first_indexed | 2024-03-09T16:59:03Z |
| format | Article |
| id | doaj.art-e078c6d29d33437387d53134aa00d45c |
| institution | Directory Open Access Journal |
| issn | 2079-6374 |
| language | English |
| last_indexed | 2024-03-09T16:59:03Z |
| publishDate | 2023-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biosensors |
| spelling | doaj.art-e078c6d29d33437387d53134aa00d45c2023-11-24T14:32:25ZengMDPI AGBiosensors2079-63742023-11-01131197910.3390/bios13110979Collision Enhanced Raman Scattering (CERS): An Ultra-High Efficient Raman Enhancement Technique for Hollow Core Photonic Crystal Fiber Based Raman Spectroscopy Gas AnalyzerMaryam Shirmohammad0Michael A. Short1Haishan Zeng2Department of Physics and Astronomy, University of British Columbia, 6224 Agricultural Road, Vancouver, BC V6T 1Z1, CanadaImaging Unit, Integrative Oncology Department, BC Cancer Research Institute, Vancouver, BC V5Z 1L3, CanadaDepartment of Physics and Astronomy, University of British Columbia, 6224 Agricultural Road, Vancouver, BC V6T 1Z1, CanadaRaman enhancement techniques are essential for gas analysis to increase the detection sensitivity of a Raman spectroscopy system. We have developed an efficient Raman enhancement technique called the collision-enhanced Raman scattering (CERS), where the active Raman gas as the analyte is mixed with a buffer gas inside the hollow-core photonic-crystal fiber (HCPCF) of a fiber-enhanced Raman spectroscopy (FERS) system. This results in an enhanced Raman signal from the analyte gas. In this study, we first showed that the intensity of the 587 cm<sup>−1</sup> stimulated Raman scattering (SRS) peak of H<sub>2</sub> confined in an HCPCF is enhanced by as much as five orders of magnitude by mixing with a buffer gas such as helium or N<sub>2</sub>. Secondly, we showed that the magnitudes of Raman enhancement depend on the type of buffer gas, with helium being more efficient compared to N<sub>2</sub>. This makes helium a favorable buffer gas for CERS. Thirdly, we applied CERS for Raman measurements of propene, a metabolically interesting volatile organic compound (VOC) with an association to lung cancer. CERS resulted in a substantial enhancement of propene Raman peaks. In conclusion, the CERS we developed is a simple and efficient Raman-enhancing mechanism for improving gas analysis. It has great potential for application in breath analysis for lung cancer detection.https://www.mdpi.com/2079-6374/13/11/979collision-enhanced Raman spectroscopyhollow-core photonic-crystal fibergas analysisbreath analysisvolatile organic compoundRaman scattering |
| spellingShingle | Maryam Shirmohammad Michael A. Short Haishan Zeng Collision Enhanced Raman Scattering (CERS): An Ultra-High Efficient Raman Enhancement Technique for Hollow Core Photonic Crystal Fiber Based Raman Spectroscopy Gas Analyzer Biosensors collision-enhanced Raman spectroscopy hollow-core photonic-crystal fiber gas analysis breath analysis volatile organic compound Raman scattering |
| title | Collision Enhanced Raman Scattering (CERS): An Ultra-High Efficient Raman Enhancement Technique for Hollow Core Photonic Crystal Fiber Based Raman Spectroscopy Gas Analyzer |
| title_full | Collision Enhanced Raman Scattering (CERS): An Ultra-High Efficient Raman Enhancement Technique for Hollow Core Photonic Crystal Fiber Based Raman Spectroscopy Gas Analyzer |
| title_fullStr | Collision Enhanced Raman Scattering (CERS): An Ultra-High Efficient Raman Enhancement Technique for Hollow Core Photonic Crystal Fiber Based Raman Spectroscopy Gas Analyzer |
| title_full_unstemmed | Collision Enhanced Raman Scattering (CERS): An Ultra-High Efficient Raman Enhancement Technique for Hollow Core Photonic Crystal Fiber Based Raman Spectroscopy Gas Analyzer |
| title_short | Collision Enhanced Raman Scattering (CERS): An Ultra-High Efficient Raman Enhancement Technique for Hollow Core Photonic Crystal Fiber Based Raman Spectroscopy Gas Analyzer |
| title_sort | collision enhanced raman scattering cers an ultra high efficient raman enhancement technique for hollow core photonic crystal fiber based raman spectroscopy gas analyzer |
| topic | collision-enhanced Raman spectroscopy hollow-core photonic-crystal fiber gas analysis breath analysis volatile organic compound Raman scattering |
| url | https://www.mdpi.com/2079-6374/13/11/979 |
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