Multimodal acoustic-electric trigeminal nerve stimulation modulates conscious perception
Multimodal stimulation can reverse pathological neural activity and improve symptoms in neuropsychiatric diseases. Recent research shows that multimodal acoustic-electric trigeminal-nerve stimulation (TNS) (i.e., musical stimulation synchronized to electrical stimulation of the trigeminal nerve) can...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2024-01-01
|
| Series: | NeuroImage |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1053811923006262 |
| _version_ | 1827385817795919872 |
|---|---|
| author | Min Wu Ryszard Auksztulewicz Lars Riecke |
| author_facet | Min Wu Ryszard Auksztulewicz Lars Riecke |
| author_sort | Min Wu |
| collection | DOAJ |
| description | Multimodal stimulation can reverse pathological neural activity and improve symptoms in neuropsychiatric diseases. Recent research shows that multimodal acoustic-electric trigeminal-nerve stimulation (TNS) (i.e., musical stimulation synchronized to electrical stimulation of the trigeminal nerve) can improve consciousness in patients with disorders of consciousness. However, the reliability and mechanism of this novel approach remain largely unknown. We explored the effects of multimodal acoustic-electric TNS in healthy human participants by assessing conscious perception before and after stimulation using behavioral and neural measures in tactile and auditory target-detection tasks. To explore the mechanisms underlying the putative effects of acoustic-electric stimulation, we fitted a biologically plausible neural network model to the neural data using dynamic causal modeling. We observed that (1) acoustic-electric stimulation improves conscious tactile perception without a concomitant change in auditory perception, (2) this improvement is caused by the interplay of the acoustic and electric stimulation rather than any of the unimodal stimulation alone, and (3) the effect of acoustic-electric stimulation on conscious perception correlates with inter-regional connection changes in a recurrent neural processing model. These results provide evidence that acoustic-electric TNS can promote conscious perception. Alterations in inter-regional cortical connections might be the mechanism by which acoustic-electric TNS achieves its consciousness benefits. |
| first_indexed | 2024-03-08T15:32:05Z |
| format | Article |
| id | doaj.art-e07997aa946d4cc18f96263cdb38d38a |
| institution | Directory Open Access Journal |
| issn | 1095-9572 |
| language | English |
| last_indexed | 2024-03-08T15:32:05Z |
| publishDate | 2024-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | NeuroImage |
| spelling | doaj.art-e07997aa946d4cc18f96263cdb38d38a2024-01-10T04:34:52ZengElsevierNeuroImage1095-95722024-01-01285120476Multimodal acoustic-electric trigeminal nerve stimulation modulates conscious perceptionMin Wu0Ryszard Auksztulewicz1Lars Riecke2Department of Cognitive Neuroscience, Faculty of Psychology and Neuroscience, Maastricht University, 6229 EV Maastricht, the Netherlands; Corresponding author.Department of Education and Psychology, Freie Universität Berlin, Berlin 14195, GermanyDepartment of Cognitive Neuroscience, Faculty of Psychology and Neuroscience, Maastricht University, 6229 EV Maastricht, the NetherlandsMultimodal stimulation can reverse pathological neural activity and improve symptoms in neuropsychiatric diseases. Recent research shows that multimodal acoustic-electric trigeminal-nerve stimulation (TNS) (i.e., musical stimulation synchronized to electrical stimulation of the trigeminal nerve) can improve consciousness in patients with disorders of consciousness. However, the reliability and mechanism of this novel approach remain largely unknown. We explored the effects of multimodal acoustic-electric TNS in healthy human participants by assessing conscious perception before and after stimulation using behavioral and neural measures in tactile and auditory target-detection tasks. To explore the mechanisms underlying the putative effects of acoustic-electric stimulation, we fitted a biologically plausible neural network model to the neural data using dynamic causal modeling. We observed that (1) acoustic-electric stimulation improves conscious tactile perception without a concomitant change in auditory perception, (2) this improvement is caused by the interplay of the acoustic and electric stimulation rather than any of the unimodal stimulation alone, and (3) the effect of acoustic-electric stimulation on conscious perception correlates with inter-regional connection changes in a recurrent neural processing model. These results provide evidence that acoustic-electric TNS can promote conscious perception. Alterations in inter-regional cortical connections might be the mechanism by which acoustic-electric TNS achieves its consciousness benefits.http://www.sciencedirect.com/science/article/pii/S1053811923006262Multimodal stimulationTrigeminal-nerve stimulationConscious perceptionDynamic-causal modeling |
| spellingShingle | Min Wu Ryszard Auksztulewicz Lars Riecke Multimodal acoustic-electric trigeminal nerve stimulation modulates conscious perception NeuroImage Multimodal stimulation Trigeminal-nerve stimulation Conscious perception Dynamic-causal modeling |
| title | Multimodal acoustic-electric trigeminal nerve stimulation modulates conscious perception |
| title_full | Multimodal acoustic-electric trigeminal nerve stimulation modulates conscious perception |
| title_fullStr | Multimodal acoustic-electric trigeminal nerve stimulation modulates conscious perception |
| title_full_unstemmed | Multimodal acoustic-electric trigeminal nerve stimulation modulates conscious perception |
| title_short | Multimodal acoustic-electric trigeminal nerve stimulation modulates conscious perception |
| title_sort | multimodal acoustic electric trigeminal nerve stimulation modulates conscious perception |
| topic | Multimodal stimulation Trigeminal-nerve stimulation Conscious perception Dynamic-causal modeling |
| url | http://www.sciencedirect.com/science/article/pii/S1053811923006262 |
| work_keys_str_mv | AT minwu multimodalacousticelectrictrigeminalnervestimulationmodulatesconsciousperception AT ryszardauksztulewicz multimodalacousticelectrictrigeminalnervestimulationmodulatesconsciousperception AT larsriecke multimodalacousticelectrictrigeminalnervestimulationmodulatesconsciousperception |