Enhanced Integrin Activation of PLD2-Deficient Platelets Accelerates Inflammation after Myocardial Infarction

Enhanced Integrin Activation of PLD2-Deficient Platelets Accelerates Inflammation after Myocardial Infarction

Background: Phospholipase (PL)D1 is crucial for integrin α<sub>IIb</sub>β<sub>3</sub> activation of platelets in arterial thrombosis and TNF-α-mediated inflammation and TGF-β-mediated collagen scar formation after myocardial infarction (MI) in mice. Enzymatic activity of PLD...

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Bibliographic Details
Main Authors: Aglaia Maria Klose, Meike Klier, Simone Gorressen, Margitta Elvers
Format: Article
Language:English
Published: MDPI AG 2020-05-01
Series:International Journal of Molecular Sciences
Subjects:
Phospholipase D2
myocardial infarction
inflammation
integrin
Interleukin-6
TGF-β
Online Access:https://www.mdpi.com/1422-0067/21/9/3210

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