Association of functional polymorphisms in interferon regulatory factor 2 (IRF2) with susceptibility to systemic lupus erythematosus: a case-control association study.

Association of functional polymorphisms in interferon regulatory factor 2 (IRF2) with susceptibility to systemic lupus erythematosus: a case-control association study.

Interferon regulatory factor 2 (IRF2) negatively regulates type I interferon (IFN) responses, while it plays a role in induction of Th1 differentiation. Previous linkage and association studies in European-American populations suggested genetic role of IRF2 in systemic lupus erythematosus (SLE); how...

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Main Authors: Aya Kawasaki, Hiroshi Furukawa, Nao Nishida, Eiji Warabi, Yuya Kondo, Satoshi Ito, Isao Matsumoto, Makio Kusaoi, Hirofumi Amano, Akiko Suda, Shouhei Nagaoka, Keigo Setoguchi, Tatsuo Nagai, Shunsei Hirohata, Kota Shimada, Shoji Sugii, Akira Okamoto, Noriyuki Chiba, Eiichi Suematsu, Shigeru Ohno, Masao Katayama, Akiko Okamoto, Hajime Kono, Katsushi Tokunaga, Yoshinari Takasaki, Hiroshi Hashimoto, Takayuki Sumida, Shigeto Tohma, Naoyuki Tsuchiya
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4186848?pdf=render

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