Retroperitoneum ganglioneuroma: imaging features and surgical outcomes of 35 cases at a Chinese Institution
Abstract Background The preoperative evaluation is crucial for diagnosis and surgical plan of retroperitoneum ganglioneuroma (GN). In this study, we reviewed a relatively large series of histopathological proved retroperitoneum GN cases, summarized the imaging features and further depicted risk fact...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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BMC
2021-07-01
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| Series: | BMC Medical Imaging |
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| Online Access: | https://doi.org/10.1186/s12880-021-00643-y |
| _version_ | 1819088023279632384 |
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| author | Qian-Wen Zhang Tao Song Pan-Pan Yang Qiang Hao |
| author_facet | Qian-Wen Zhang Tao Song Pan-Pan Yang Qiang Hao |
| author_sort | Qian-Wen Zhang |
| collection | DOAJ |
| description | Abstract Background The preoperative evaluation is crucial for diagnosis and surgical plan of retroperitoneum ganglioneuroma (GN). In this study, we reviewed a relatively large series of histopathological proved retroperitoneum GN cases, summarized the imaging features and further depicted risk factors of increased surgical blood loss. Methods A total of 35 (18 male, 17 female) patients were retrospectively enrolled from January 2012 to June 2019 at our institution. Among them, 24 patients had undergone CT scans and 19 patients had undergone MR examination before treatment. The clinical and radiological features were analyzed and the relationships between image features and surgical blood loss were evaluated. Results The media age of the involved 35 patients was 40 years (range, 14–66 years). The histological tumor size was 10.12 ± 4.56 cm for average. Retroperitoneum GN was relatively low density on unenhanced CT images and showed delayed progressive enhancement on enhanced CT and MR images. The whorled sign could be seen in 14 patients. The vessel encasement sign could be found in 17 patients. Univariate analysis revealed maximal tumor size measured on axial image, maximal tumor size measured on coronal image, encasing one or both renal pedicles, encasing the aorta and/or vena cava and whorled sign on MRI showed significant difference between the blood loss ≥ 400 ml and blood loss < 400 ml group. Logistic regression further detected that maximal tumor size measured on axial images (OR: 1.12; 95% CI: 1.02–1.24; P = 0.023) and encasing one or both renal pedicles (OR: 22.39; 95% CI: 1.35–372.99; P = 0.030) were independently correlated with surgical blood loss. Conclusions Preoperative CT and MR imaging analysis was valuable for both diagnosis and surgical risk prediction of retroperitoneum GN. |
| first_indexed | 2024-12-21T21:45:27Z |
| format | Article |
| id | doaj.art-e07f1d1c9dd74419bdd25c284a4415e1 |
| institution | Directory Open Access Journal |
| issn | 1471-2342 |
| language | English |
| last_indexed | 2024-12-21T21:45:27Z |
| publishDate | 2021-07-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Medical Imaging |
| spelling | doaj.art-e07f1d1c9dd74419bdd25c284a4415e12022-12-21T18:49:15ZengBMCBMC Medical Imaging1471-23422021-07-0121111010.1186/s12880-021-00643-yRetroperitoneum ganglioneuroma: imaging features and surgical outcomes of 35 cases at a Chinese InstitutionQian-Wen Zhang0Tao Song1Pan-Pan Yang2Qiang Hao3Department of Radiology, Changhai Hospital, The Navy Medical University (Second Military Medical University)Department of Radiology, Changhai Hospital, The Navy Medical University (Second Military Medical University)Department of Radiology, Changhai Hospital, The Navy Medical University (Second Military Medical University)Department of Radiology, Changhai Hospital, The Navy Medical University (Second Military Medical University)Abstract Background The preoperative evaluation is crucial for diagnosis and surgical plan of retroperitoneum ganglioneuroma (GN). In this study, we reviewed a relatively large series of histopathological proved retroperitoneum GN cases, summarized the imaging features and further depicted risk factors of increased surgical blood loss. Methods A total of 35 (18 male, 17 female) patients were retrospectively enrolled from January 2012 to June 2019 at our institution. Among them, 24 patients had undergone CT scans and 19 patients had undergone MR examination before treatment. The clinical and radiological features were analyzed and the relationships between image features and surgical blood loss were evaluated. Results The media age of the involved 35 patients was 40 years (range, 14–66 years). The histological tumor size was 10.12 ± 4.56 cm for average. Retroperitoneum GN was relatively low density on unenhanced CT images and showed delayed progressive enhancement on enhanced CT and MR images. The whorled sign could be seen in 14 patients. The vessel encasement sign could be found in 17 patients. Univariate analysis revealed maximal tumor size measured on axial image, maximal tumor size measured on coronal image, encasing one or both renal pedicles, encasing the aorta and/or vena cava and whorled sign on MRI showed significant difference between the blood loss ≥ 400 ml and blood loss < 400 ml group. Logistic regression further detected that maximal tumor size measured on axial images (OR: 1.12; 95% CI: 1.02–1.24; P = 0.023) and encasing one or both renal pedicles (OR: 22.39; 95% CI: 1.35–372.99; P = 0.030) were independently correlated with surgical blood loss. Conclusions Preoperative CT and MR imaging analysis was valuable for both diagnosis and surgical risk prediction of retroperitoneum GN.https://doi.org/10.1186/s12880-021-00643-yGanglioneuromaRetroperitoneumComputed tomographyMagnetic resonance imagingSurgery |
| spellingShingle | Qian-Wen Zhang Tao Song Pan-Pan Yang Qiang Hao Retroperitoneum ganglioneuroma: imaging features and surgical outcomes of 35 cases at a Chinese Institution BMC Medical Imaging Ganglioneuroma Retroperitoneum Computed tomography Magnetic resonance imaging Surgery |
| title | Retroperitoneum ganglioneuroma: imaging features and surgical outcomes of 35 cases at a Chinese Institution |
| title_full | Retroperitoneum ganglioneuroma: imaging features and surgical outcomes of 35 cases at a Chinese Institution |
| title_fullStr | Retroperitoneum ganglioneuroma: imaging features and surgical outcomes of 35 cases at a Chinese Institution |
| title_full_unstemmed | Retroperitoneum ganglioneuroma: imaging features and surgical outcomes of 35 cases at a Chinese Institution |
| title_short | Retroperitoneum ganglioneuroma: imaging features and surgical outcomes of 35 cases at a Chinese Institution |
| title_sort | retroperitoneum ganglioneuroma imaging features and surgical outcomes of 35 cases at a chinese institution |
| topic | Ganglioneuroma Retroperitoneum Computed tomography Magnetic resonance imaging Surgery |
| url | https://doi.org/10.1186/s12880-021-00643-y |
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