Functional Coordination among the Golgi Complex, the Centrosome and the Microtubule Cytoskeleton during the Cell Cycle
The Golgi complex of mammalian cells is organized in a ribbon-like structure often closely associated with the centrosome during interphase. Conversely, the Golgi complex assumes a fragmented and dispersed configuration away from the centrosome during mitosis. The structure of the Golgi complex and...
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| Format: | Article |
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MDPI AG
2022-01-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/11/3/354 |
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| author | Fabiola Mascanzoni Roberta Iannitti Antonino Colanzi |
| author_facet | Fabiola Mascanzoni Roberta Iannitti Antonino Colanzi |
| author_sort | Fabiola Mascanzoni |
| collection | DOAJ |
| description | The Golgi complex of mammalian cells is organized in a ribbon-like structure often closely associated with the centrosome during interphase. Conversely, the Golgi complex assumes a fragmented and dispersed configuration away from the centrosome during mitosis. The structure of the Golgi complex and the relative position to the centrosome are dynamically regulated by microtubules. Many pieces of evidence reveal that this microtubule-mediated dynamic association between the Golgi complex and centrosome is of functional significance in cell polarization and division. Here, we summarize findings indicating how the Golgi complex and the centrosome cooperate in organizing the microtubule network for the directional protein transport and centrosome positioning required for cell polarization and regulating fundamental cell division processes. |
| first_indexed | 2024-03-10T00:04:47Z |
| format | Article |
| id | doaj.art-e07f32f28eab49cd8f96b07c97d1a000 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-10T00:04:47Z |
| publishDate | 2022-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-e07f32f28eab49cd8f96b07c97d1a0002023-11-23T16:10:28ZengMDPI AGCells2073-44092022-01-0111335410.3390/cells11030354Functional Coordination among the Golgi Complex, the Centrosome and the Microtubule Cytoskeleton during the Cell CycleFabiola Mascanzoni0Roberta Iannitti1Antonino Colanzi2Institute of Experimental Endocrinology and Oncology “G. Salvatore” (IEOS), National Research Council (CNR), Via P. Castellino 111, 80131 Naples, ItalyInstitute of Experimental Endocrinology and Oncology “G. Salvatore” (IEOS), National Research Council (CNR), Via P. Castellino 111, 80131 Naples, ItalyInstitute of Experimental Endocrinology and Oncology “G. Salvatore” (IEOS), National Research Council (CNR), Via P. Castellino 111, 80131 Naples, ItalyThe Golgi complex of mammalian cells is organized in a ribbon-like structure often closely associated with the centrosome during interphase. Conversely, the Golgi complex assumes a fragmented and dispersed configuration away from the centrosome during mitosis. The structure of the Golgi complex and the relative position to the centrosome are dynamically regulated by microtubules. Many pieces of evidence reveal that this microtubule-mediated dynamic association between the Golgi complex and centrosome is of functional significance in cell polarization and division. Here, we summarize findings indicating how the Golgi complex and the centrosome cooperate in organizing the microtubule network for the directional protein transport and centrosome positioning required for cell polarization and regulating fundamental cell division processes.https://www.mdpi.com/2073-4409/11/3/354Golgi complexcentrosomemicrotubulescell migrationmitosismitotic spindle |
| spellingShingle | Fabiola Mascanzoni Roberta Iannitti Antonino Colanzi Functional Coordination among the Golgi Complex, the Centrosome and the Microtubule Cytoskeleton during the Cell Cycle Cells Golgi complex centrosome microtubules cell migration mitosis mitotic spindle |
| title | Functional Coordination among the Golgi Complex, the Centrosome and the Microtubule Cytoskeleton during the Cell Cycle |
| title_full | Functional Coordination among the Golgi Complex, the Centrosome and the Microtubule Cytoskeleton during the Cell Cycle |
| title_fullStr | Functional Coordination among the Golgi Complex, the Centrosome and the Microtubule Cytoskeleton during the Cell Cycle |
| title_full_unstemmed | Functional Coordination among the Golgi Complex, the Centrosome and the Microtubule Cytoskeleton during the Cell Cycle |
| title_short | Functional Coordination among the Golgi Complex, the Centrosome and the Microtubule Cytoskeleton during the Cell Cycle |
| title_sort | functional coordination among the golgi complex the centrosome and the microtubule cytoskeleton during the cell cycle |
| topic | Golgi complex centrosome microtubules cell migration mitosis mitotic spindle |
| url | https://www.mdpi.com/2073-4409/11/3/354 |
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