A meta-analysis of epigenome-wide association studies on pregnancy vitamin B12 concentrations and offspring DNA methylation
Circulating vitamin B12 concentrations during pregnancy are associated with offspring health. Foetal DNA methylation changes could underlie these associations. Within the Pregnancy And Childhood Epigenetics Consortium, we meta-analysed epigenome-wide associations of circulating vitamin B12 concentra...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2023-12-01
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| Series: | Epigenetics |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/15592294.2023.2202835 |
| _version_ | 1827811421009739776 |
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| author | Giulietta S. Monasso Thanh T. Hoang Giulia Mancano Sílvia Fernández-Barrés John Dou Vincent W.V. Jaddoe Christian M. Page Laura Johnson Mariona Bustamante Kelly M. Bakulski Siri E. Håberg Per M. Ueland Thomas Battram Simon K. Merid Erik Melén Doretta Caramaschi Leanne K. Küpers Jordi Sunyer Wenche Nystad Sandra G. Heil Rebecca J. Schmidt Martine Vrijheid Gemma C. Sharp Stephanie J. London Janine F. Felix |
| author_facet | Giulietta S. Monasso Thanh T. Hoang Giulia Mancano Sílvia Fernández-Barrés John Dou Vincent W.V. Jaddoe Christian M. Page Laura Johnson Mariona Bustamante Kelly M. Bakulski Siri E. Håberg Per M. Ueland Thomas Battram Simon K. Merid Erik Melén Doretta Caramaschi Leanne K. Küpers Jordi Sunyer Wenche Nystad Sandra G. Heil Rebecca J. Schmidt Martine Vrijheid Gemma C. Sharp Stephanie J. London Janine F. Felix |
| author_sort | Giulietta S. Monasso |
| collection | DOAJ |
| description | Circulating vitamin B12 concentrations during pregnancy are associated with offspring health. Foetal DNA methylation changes could underlie these associations. Within the Pregnancy And Childhood Epigenetics Consortium, we meta-analysed epigenome-wide associations of circulating vitamin B12 concentrations in mothers during pregnancy (n = 2,420) or cord blood (n = 1,029), with cord blood DNA methylation. Maternal and newborn vitamin B12 concentrations were associated with DNA methylation at 109 and 7 CpGs, respectively (False Discovery Rate P-value <0.05). Persistent associations with DNA methylation in the peripheral blood of up to 482 children aged 4–10 y were observed for 40.7% of CpGs associated with maternal vitamin B12 and 57.1% of CpGs associated with newborn vitamin B12. Of the CpGs identified in the maternal meta-analyses, 4.6% were associated with either birth weight or gestational age in a previous work. For the newborn meta-analysis, this was the case for 14.3% of the identified CpGs. Also, of the CpGs identified in the newborn meta-analysis, 14.3% and 28.6%, respectively, were associated with childhood cognitive skills and nonverbal IQ. Of the 109 CpGs associated with maternal vitamin B12, 18.3% were associated with nearby gene expression. In this study, we showed that maternal and newborn vitamin B12 concentrations are associated with DNA methylation at multiple CpGs in offspring blood (PFDR<0.05). Whether this differential DNA methylation underlies associations of vitamin B12 concentrations with child health outcomes, such as birth weight, gestational age, and childhood cognition, should be further examined in future studies. |
| first_indexed | 2024-03-11T23:05:04Z |
| format | Article |
| id | doaj.art-e080ef2c12ef4dcea3bef66544558f52 |
| institution | Directory Open Access Journal |
| issn | 1559-2294 1559-2308 |
| language | English |
| last_indexed | 2024-03-11T23:05:04Z |
| publishDate | 2023-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Epigenetics |
| spelling | doaj.art-e080ef2c12ef4dcea3bef66544558f522023-09-21T13:23:13ZengTaylor & Francis GroupEpigenetics1559-22941559-23082023-12-0118110.1080/15592294.2023.22028352202835A meta-analysis of epigenome-wide association studies on pregnancy vitamin B12 concentrations and offspring DNA methylationGiulietta S. Monasso0Thanh T. Hoang1Giulia Mancano2Sílvia Fernández-Barrés3John Dou4Vincent W.V. Jaddoe5Christian M. Page6Laura Johnson7Mariona Bustamante8Kelly M. Bakulski9Siri E. Håberg10Per M. Ueland11Thomas Battram12Simon K. Merid13Erik Melén14Doretta Caramaschi15Leanne K. Küpers16Jordi Sunyer17Wenche Nystad18Sandra G. Heil19Rebecca J. Schmidt20Martine Vrijheid21Gemma C. Sharp22Stephanie J. London23Janine F. Felix24University Medical Center RotterdamEpidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle ParkUniversity of BristolISGlobal, Bacelona Institute for Global HealthUniversity of MichiganUniversity Medical Center RotterdamNorwegian Institute of Public HealthUniversity of BristolISGlobal, Bacelona Institute for Global HealthUniversity of MichiganNorwegian Institute of Public HealthBEVITALUniversity of BristolInstitute of Environmental Medicine, Karolinska InstitutetInstitute of Environmental Medicine, Karolinska InstitutetUniversity of ExeterUniversity Medical Center RotterdamISGlobal, Bacelona Institute for Global HealthNorwegian Institute of Public HealthUniversity Medical Center RotterdamUniversity of California DavisISGlobal, Bacelona Institute for Global HealthUniversity of BristolEpidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle ParkUniversity Medical Center RotterdamCirculating vitamin B12 concentrations during pregnancy are associated with offspring health. Foetal DNA methylation changes could underlie these associations. Within the Pregnancy And Childhood Epigenetics Consortium, we meta-analysed epigenome-wide associations of circulating vitamin B12 concentrations in mothers during pregnancy (n = 2,420) or cord blood (n = 1,029), with cord blood DNA methylation. Maternal and newborn vitamin B12 concentrations were associated with DNA methylation at 109 and 7 CpGs, respectively (False Discovery Rate P-value <0.05). Persistent associations with DNA methylation in the peripheral blood of up to 482 children aged 4–10 y were observed for 40.7% of CpGs associated with maternal vitamin B12 and 57.1% of CpGs associated with newborn vitamin B12. Of the CpGs identified in the maternal meta-analyses, 4.6% were associated with either birth weight or gestational age in a previous work. For the newborn meta-analysis, this was the case for 14.3% of the identified CpGs. Also, of the CpGs identified in the newborn meta-analysis, 14.3% and 28.6%, respectively, were associated with childhood cognitive skills and nonverbal IQ. Of the 109 CpGs associated with maternal vitamin B12, 18.3% were associated with nearby gene expression. In this study, we showed that maternal and newborn vitamin B12 concentrations are associated with DNA methylation at multiple CpGs in offspring blood (PFDR<0.05). Whether this differential DNA methylation underlies associations of vitamin B12 concentrations with child health outcomes, such as birth weight, gestational age, and childhood cognition, should be further examined in future studies.http://dx.doi.org/10.1080/15592294.2023.2202835vitamin b12dna methylationepidemiologycohort studymeta-analysispace consortium |
| spellingShingle | Giulietta S. Monasso Thanh T. Hoang Giulia Mancano Sílvia Fernández-Barrés John Dou Vincent W.V. Jaddoe Christian M. Page Laura Johnson Mariona Bustamante Kelly M. Bakulski Siri E. Håberg Per M. Ueland Thomas Battram Simon K. Merid Erik Melén Doretta Caramaschi Leanne K. Küpers Jordi Sunyer Wenche Nystad Sandra G. Heil Rebecca J. Schmidt Martine Vrijheid Gemma C. Sharp Stephanie J. London Janine F. Felix A meta-analysis of epigenome-wide association studies on pregnancy vitamin B12 concentrations and offspring DNA methylation Epigenetics vitamin b12 dna methylation epidemiology cohort study meta-analysis pace consortium |
| title | A meta-analysis of epigenome-wide association studies on pregnancy vitamin B12 concentrations and offspring DNA methylation |
| title_full | A meta-analysis of epigenome-wide association studies on pregnancy vitamin B12 concentrations and offspring DNA methylation |
| title_fullStr | A meta-analysis of epigenome-wide association studies on pregnancy vitamin B12 concentrations and offspring DNA methylation |
| title_full_unstemmed | A meta-analysis of epigenome-wide association studies on pregnancy vitamin B12 concentrations and offspring DNA methylation |
| title_short | A meta-analysis of epigenome-wide association studies on pregnancy vitamin B12 concentrations and offspring DNA methylation |
| title_sort | meta analysis of epigenome wide association studies on pregnancy vitamin b12 concentrations and offspring dna methylation |
| topic | vitamin b12 dna methylation epidemiology cohort study meta-analysis pace consortium |
| url | http://dx.doi.org/10.1080/15592294.2023.2202835 |
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