Tissue of origin dictates GOT1 dependence and confers synthetic lethality to radiotherapy

Tissue of origin dictates GOT1 dependence and confers synthetic lethality to radiotherapy

Abstract Background Metabolic programs in cancer cells are influenced by genotype and the tissue of origin. We have previously shown that central carbon metabolism is rewired in pancreatic ductal adenocarcinoma (PDA) to support proliferation through a glutamate oxaloacetate transaminase 1 (GOT1)-dep...

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Bibliographic Details
Main Authors: Barbara S. Nelson, Lin Lin, Daniel M. Kremer, Cristovão M. Sousa, Cecilia Cotta-Ramusino, Amy Myers, Johanna Ramos, Tina Gao, Ilya Kovalenko, Kari Wilder-Romans, Joseph Dresser, Mary Davis, Ho-Joon Lee, Zeribe C. Nwosu, Scott Campit, Oksana Mashadova, Brandon N. Nicolay, Zachary P. Tolstyka, Christopher J. Halbrook, Sriram Chandrasekaran, John M. Asara, Howard C. Crawford, Lewis C. Cantley, Alec C. Kimmelman, Daniel R. Wahl, Costas A. Lyssiotis
Format: Article
Language:English
Published: BMC 2020-01-01
Series:Cancer & Metabolism
Subjects:
Metabolomics
Stable isotope tracing
Fluxomics
Pancreatic cancer
PDA
Colorectal cancer
Online Access:https://doi.org/10.1186/s40170-019-0202-2

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