Clinical and Virological Response to Convalescent Plasma in a Chronic Lymphocytic Leukemia Patient with COVID-19 Pneumonia
The burden of COVID-19 remains unchanged for immunocompromised patients who do not respond to vaccines. Unfortunately, Omicron sublineages are resistant to monoclonal antibodies authorized in Europe so far, and small chemical antivirals have contraindications and toxicities that have not been studie...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-07-01
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| Series: | Life |
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| Online Access: | https://www.mdpi.com/2075-1729/12/7/1098 |
| _version_ | 1797433423950774272 |
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| author | Giovanni Belcari Alberto Conti Alessandro Mazzoni Maria Lanza Paola Mazzetti Daniele Focosi |
| author_facet | Giovanni Belcari Alberto Conti Alessandro Mazzoni Maria Lanza Paola Mazzetti Daniele Focosi |
| author_sort | Giovanni Belcari |
| collection | DOAJ |
| description | The burden of COVID-19 remains unchanged for immunocompromised patients who do not respond to vaccines. Unfortunately, Omicron sublineages are resistant to monoclonal antibodies authorized in Europe so far, and small chemical antivirals have contraindications and toxicities that have not been studied in these patients. We report here the successful treatment of COVID-19 pneumonia lasting for 4 months after the transfusion of COVID-19 convalescent plasma (CCP) in a patient with severe immunosuppression due to both chronic lymphocytic leukemia and venetoclax treatment. The patient achieved a complete clinical, radiological and virological response after six transfusions (600 mL each) of high-titer CCP collected from triple-vaccinated and convalescent donors. This dramatic case adds to the mounting evidence of CCP efficacy in immunocompromised patients, provided that high-titer and large volumes are infused. |
| first_indexed | 2024-03-09T10:16:49Z |
| format | Article |
| id | doaj.art-e086926b483140d3adfb348ef95d31f9 |
| institution | Directory Open Access Journal |
| issn | 2075-1729 |
| language | English |
| last_indexed | 2024-03-09T10:16:49Z |
| publishDate | 2022-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Life |
| spelling | doaj.art-e086926b483140d3adfb348ef95d31f92023-12-01T22:22:06ZengMDPI AGLife2075-17292022-07-01127109810.3390/life12071098Clinical and Virological Response to Convalescent Plasma in a Chronic Lymphocytic Leukemia Patient with COVID-19 PneumoniaGiovanni Belcari0Alberto Conti1Alessandro Mazzoni2Maria Lanza3Paola Mazzetti4Daniele Focosi5Division of Emergency Medicine, ASL Toscana Nord-Ovest, 56124 Pisa, ItalyDepartment of Emergency Medicine, ASL Toscana Nord-Ovest, 56124 Pisa, ItalyDivision of Transfusion Medicine, Pisa University Hospital, 56124 Pisa, ItalyNorth-Western Tuscany Blood Bank, Pisa University Hospital, 56124 Pisa, ItalyDivision of Virology, Pisa University Hospital, 56124 Pisa, ItalyNorth-Western Tuscany Blood Bank, Pisa University Hospital, 56124 Pisa, ItalyThe burden of COVID-19 remains unchanged for immunocompromised patients who do not respond to vaccines. Unfortunately, Omicron sublineages are resistant to monoclonal antibodies authorized in Europe so far, and small chemical antivirals have contraindications and toxicities that have not been studied in these patients. We report here the successful treatment of COVID-19 pneumonia lasting for 4 months after the transfusion of COVID-19 convalescent plasma (CCP) in a patient with severe immunosuppression due to both chronic lymphocytic leukemia and venetoclax treatment. The patient achieved a complete clinical, radiological and virological response after six transfusions (600 mL each) of high-titer CCP collected from triple-vaccinated and convalescent donors. This dramatic case adds to the mounting evidence of CCP efficacy in immunocompromised patients, provided that high-titer and large volumes are infused.https://www.mdpi.com/2075-1729/12/7/1098COVID-19SARS-CoV-2chronic lymphocytic leukemiavenetoclaxconvalescent plasmaimmunosuppression |
| spellingShingle | Giovanni Belcari Alberto Conti Alessandro Mazzoni Maria Lanza Paola Mazzetti Daniele Focosi Clinical and Virological Response to Convalescent Plasma in a Chronic Lymphocytic Leukemia Patient with COVID-19 Pneumonia Life COVID-19 SARS-CoV-2 chronic lymphocytic leukemia venetoclax convalescent plasma immunosuppression |
| title | Clinical and Virological Response to Convalescent Plasma in a Chronic Lymphocytic Leukemia Patient with COVID-19 Pneumonia |
| title_full | Clinical and Virological Response to Convalescent Plasma in a Chronic Lymphocytic Leukemia Patient with COVID-19 Pneumonia |
| title_fullStr | Clinical and Virological Response to Convalescent Plasma in a Chronic Lymphocytic Leukemia Patient with COVID-19 Pneumonia |
| title_full_unstemmed | Clinical and Virological Response to Convalescent Plasma in a Chronic Lymphocytic Leukemia Patient with COVID-19 Pneumonia |
| title_short | Clinical and Virological Response to Convalescent Plasma in a Chronic Lymphocytic Leukemia Patient with COVID-19 Pneumonia |
| title_sort | clinical and virological response to convalescent plasma in a chronic lymphocytic leukemia patient with covid 19 pneumonia |
| topic | COVID-19 SARS-CoV-2 chronic lymphocytic leukemia venetoclax convalescent plasma immunosuppression |
| url | https://www.mdpi.com/2075-1729/12/7/1098 |
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