Histological and Radiological Evaluation of Low-Intensity Pulsed Ultrasound Versus Whole Body Vibration on Healing of Mandibular Bone Defects in Rats
<i>Background and Objectives</i>: Mechanical stimulation can improve the structural properties of the fracture site and induce the differentiation of different cell types for bone regeneration. This study aimed to compare the effect of low-intensity pulsed ultrasound stimulation (LIPUS)...
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MDPI AG
2020-09-01
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| Series: | Medicina |
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| Online Access: | https://www.mdpi.com/1010-660X/56/9/457 |
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| author | Milad Etemadi Sh Nan-Chen Hsieh Seyed Shahin Movahed Mohammadi Shahrooz Momeni Seyed Mohammad Razavi Javad Alizargar |
| author_facet | Milad Etemadi Sh Nan-Chen Hsieh Seyed Shahin Movahed Mohammadi Shahrooz Momeni Seyed Mohammad Razavi Javad Alizargar |
| author_sort | Milad Etemadi Sh |
| collection | DOAJ |
| description | <i>Background and Objectives</i>: Mechanical stimulation can improve the structural properties of the fracture site and induce the differentiation of different cell types for bone regeneration. This study aimed to compare the effect of low-intensity pulsed ultrasound stimulation (LIPUS) versus whole body vibration (WBV) on healing of mandibular bone defects. <i>Materials and Methods</i>: A mandibular defect was created in 66 rats. The rats were randomly divided into two groups of rats. Each group was subdivided randomly by three groups (<i>n</i> = 11) as follows: (I) control group, (II) treatment with LIPUS, and (III) treatment with WBV. The radiographic changes in bone density, the ratio of lamellar bone to the entire bone volume, the ratio of the newly formed bone to the connective tissue and inflammation grade were evaluated after 1 and 2 months. <i>Results</i>: LIPUS significantly increased the radiographic bone density change compared to the control group at the first and second month postoperatively (<i>p</i> < 0.01). WBV only significantly increased the bone density compared to the control group at the second month after the surgery (<i>p</i> < 0.01). <i>Conclusions</i>: Application of LIPUS and WBV may enhance the regeneration of mandibular bone defects in rats. Although LIPUS and WBV are effective in mandibular bone healing, the effects of LIPUS are faster and greater than WBV. |
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| issn | 1010-660X |
| language | English |
| last_indexed | 2024-03-12T08:46:17Z |
| publishDate | 2020-09-01 |
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| series | Medicina |
| spelling | doaj.art-e08804f6bd8a449799210789f63ae3512023-09-02T16:26:58ZengMDPI AGMedicina1010-660X2020-09-015645745710.3390/medicina56090457Histological and Radiological Evaluation of Low-Intensity Pulsed Ultrasound Versus Whole Body Vibration on Healing of Mandibular Bone Defects in RatsMilad Etemadi Sh0Nan-Chen Hsieh1Seyed Shahin Movahed Mohammadi2Shahrooz Momeni3Seyed Mohammad Razavi4Javad Alizargar5Department of Oral and Maxillofacial Surgery, Dental Implants Research Center, Dental Research Institute, School of Dentistry, Isfahan University of Medical Sciences, Isfahan 8415683111, IranDepartment of Information Management, National Taipei University of Nursing and Health Sciences, Taipei City 112, TaiwanDepartment of Oral and Maxillofacial Surgery, Faculty of Dentistry, Isfahan University of Medical Sciences, Isfahan 8415683111, IranDepartment of Oral and Maxillofacial Surgery, School of Dentistry and Dental Research Center, Isfahan University of Medical Sciences, Isfahan 8415683111, IranDepartment of Oral and Maxillofacial Pathology, School of Dentistry and Dental Implants Research Center, Isfahan University of Medical Sciences, Isfahan 8415683111, IranResearch Center for Healthcare Industry Innovation, National Taipei University of Nursing and Health Sciences, Taipei City 112, Taiwan<i>Background and Objectives</i>: Mechanical stimulation can improve the structural properties of the fracture site and induce the differentiation of different cell types for bone regeneration. This study aimed to compare the effect of low-intensity pulsed ultrasound stimulation (LIPUS) versus whole body vibration (WBV) on healing of mandibular bone defects. <i>Materials and Methods</i>: A mandibular defect was created in 66 rats. The rats were randomly divided into two groups of rats. Each group was subdivided randomly by three groups (<i>n</i> = 11) as follows: (I) control group, (II) treatment with LIPUS, and (III) treatment with WBV. The radiographic changes in bone density, the ratio of lamellar bone to the entire bone volume, the ratio of the newly formed bone to the connective tissue and inflammation grade were evaluated after 1 and 2 months. <i>Results</i>: LIPUS significantly increased the radiographic bone density change compared to the control group at the first and second month postoperatively (<i>p</i> < 0.01). WBV only significantly increased the bone density compared to the control group at the second month after the surgery (<i>p</i> < 0.01). <i>Conclusions</i>: Application of LIPUS and WBV may enhance the regeneration of mandibular bone defects in rats. Although LIPUS and WBV are effective in mandibular bone healing, the effects of LIPUS are faster and greater than WBV.https://www.mdpi.com/1010-660X/56/9/457mandibular defectslow-intensity pulsed ultrasoundwhole body vibrationbone regeneration |
| spellingShingle | Milad Etemadi Sh Nan-Chen Hsieh Seyed Shahin Movahed Mohammadi Shahrooz Momeni Seyed Mohammad Razavi Javad Alizargar Histological and Radiological Evaluation of Low-Intensity Pulsed Ultrasound Versus Whole Body Vibration on Healing of Mandibular Bone Defects in Rats Medicina mandibular defects low-intensity pulsed ultrasound whole body vibration bone regeneration |
| title | Histological and Radiological Evaluation of Low-Intensity Pulsed Ultrasound Versus Whole Body Vibration on Healing of Mandibular Bone Defects in Rats |
| title_full | Histological and Radiological Evaluation of Low-Intensity Pulsed Ultrasound Versus Whole Body Vibration on Healing of Mandibular Bone Defects in Rats |
| title_fullStr | Histological and Radiological Evaluation of Low-Intensity Pulsed Ultrasound Versus Whole Body Vibration on Healing of Mandibular Bone Defects in Rats |
| title_full_unstemmed | Histological and Radiological Evaluation of Low-Intensity Pulsed Ultrasound Versus Whole Body Vibration on Healing of Mandibular Bone Defects in Rats |
| title_short | Histological and Radiological Evaluation of Low-Intensity Pulsed Ultrasound Versus Whole Body Vibration on Healing of Mandibular Bone Defects in Rats |
| title_sort | histological and radiological evaluation of low intensity pulsed ultrasound versus whole body vibration on healing of mandibular bone defects in rats |
| topic | mandibular defects low-intensity pulsed ultrasound whole body vibration bone regeneration |
| url | https://www.mdpi.com/1010-660X/56/9/457 |
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