How important is EMT for cancer metastasis?
Epithelial-to-mesenchymal transition (EMT), a biological phenomenon of cellular plasticity initially reported in embryonic development, has been increasingly recognized for its importance in cancer progression and metastasis. Despite tremendous progress being made in the past 2 decades in our unders...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2024-02-01
|
| Series: | PLoS Biology |
| Online Access: | https://journals.plos.org/plosbiology/article/file?id=10.1371/journal.pbio.3002487&type=printable |
| _version_ | 1797315948785434624 |
|---|---|
| author | Toni Celià-Terrassa Yibin Kang |
| author_facet | Toni Celià-Terrassa Yibin Kang |
| author_sort | Toni Celià-Terrassa |
| collection | DOAJ |
| description | Epithelial-to-mesenchymal transition (EMT), a biological phenomenon of cellular plasticity initially reported in embryonic development, has been increasingly recognized for its importance in cancer progression and metastasis. Despite tremendous progress being made in the past 2 decades in our understanding of the molecular mechanism and functional importance of EMT in cancer, there are several mysteries around EMT that remain unresolved. In this Unsolved Mystery, we focus on the variety of EMT types in metastasis, cooperative and collective EMT behaviors, spatiotemporal characterization of EMT, and strategies of therapeutically targeting EMT. We also highlight new technical advances that will facilitate the efforts to elucidate the unsolved mysteries of EMT in metastasis. |
| first_indexed | 2024-03-08T03:12:13Z |
| format | Article |
| id | doaj.art-e088a008d9db4a6d9eda1b6cd715b71f |
| institution | Directory Open Access Journal |
| issn | 1544-9173 1545-7885 |
| language | English |
| last_indexed | 2024-03-08T03:12:13Z |
| publishDate | 2024-02-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Biology |
| spelling | doaj.art-e088a008d9db4a6d9eda1b6cd715b71f2024-02-13T05:30:46ZengPublic Library of Science (PLoS)PLoS Biology1544-91731545-78852024-02-01222e300248710.1371/journal.pbio.3002487How important is EMT for cancer metastasis?Toni Celià-TerrassaYibin KangEpithelial-to-mesenchymal transition (EMT), a biological phenomenon of cellular plasticity initially reported in embryonic development, has been increasingly recognized for its importance in cancer progression and metastasis. Despite tremendous progress being made in the past 2 decades in our understanding of the molecular mechanism and functional importance of EMT in cancer, there are several mysteries around EMT that remain unresolved. In this Unsolved Mystery, we focus on the variety of EMT types in metastasis, cooperative and collective EMT behaviors, spatiotemporal characterization of EMT, and strategies of therapeutically targeting EMT. We also highlight new technical advances that will facilitate the efforts to elucidate the unsolved mysteries of EMT in metastasis.https://journals.plos.org/plosbiology/article/file?id=10.1371/journal.pbio.3002487&type=printable |
| spellingShingle | Toni Celià-Terrassa Yibin Kang How important is EMT for cancer metastasis? PLoS Biology |
| title | How important is EMT for cancer metastasis? |
| title_full | How important is EMT for cancer metastasis? |
| title_fullStr | How important is EMT for cancer metastasis? |
| title_full_unstemmed | How important is EMT for cancer metastasis? |
| title_short | How important is EMT for cancer metastasis? |
| title_sort | how important is emt for cancer metastasis |
| url | https://journals.plos.org/plosbiology/article/file?id=10.1371/journal.pbio.3002487&type=printable |
| work_keys_str_mv | AT toniceliaterrassa howimportantisemtforcancermetastasis AT yibinkang howimportantisemtforcancermetastasis |