Differentiating among incretin-based therapies in the management of patients with type 2 diabetes mellitus
<p>Abstract</p> <p>The glucagon-like peptide-1 receptor (GLP-1R) agonists and dipeptidyl peptidase-4 (DPP-4) inhibitors have become important options for the management of patients with type 2 diabetes mellitus. While the GLP-1R agonists and DPP-4 inhibitors act on the incretin sys...
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Format: | Article |
Language: | English |
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BMC
2012-03-01
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Series: | Diabetology & Metabolic Syndrome |
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Online Access: | http://www.dmsjournal.com/content/4/1/8 |
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author | Cobble Michael |
author_facet | Cobble Michael |
author_sort | Cobble Michael |
collection | DOAJ |
description | <p>Abstract</p> <p>The glucagon-like peptide-1 receptor (GLP-1R) agonists and dipeptidyl peptidase-4 (DPP-4) inhibitors have become important options for the management of patients with type 2 diabetes mellitus. While the GLP-1R agonists and DPP-4 inhibitors act on the incretin system to regulate glucose homeostasis, there are important clinical differences among the five agents currently available in the U.S. For example, the GLP-1R agonists require subcutaneous administration, produce pharmacological levels of GLP-1 activity, promote weight loss, have a more robust glucose-lowering effect, and have a higher incidence of adverse gastrointestinal effects. In contrast, the DPP-4 inhibitors are taken orally, increase the half-life of endogenous GLP-1, are weight neutral, and are more commonly associated with nasopharyngitis. Differences in efficacy, safety, tolerability, and cost among the incretin-based therapies are important to consider in the primary care management of patients with type 2 diabetes mellitus.</p> |
first_indexed | 2024-04-12T16:43:44Z |
format | Article |
id | doaj.art-e08a47d38f594dde8be3a9309c504db2 |
institution | Directory Open Access Journal |
issn | 1758-5996 |
language | English |
last_indexed | 2024-04-12T16:43:44Z |
publishDate | 2012-03-01 |
publisher | BMC |
record_format | Article |
series | Diabetology & Metabolic Syndrome |
spelling | doaj.art-e08a47d38f594dde8be3a9309c504db22022-12-22T03:24:41ZengBMCDiabetology & Metabolic Syndrome1758-59962012-03-0141810.1186/1758-5996-4-8Differentiating among incretin-based therapies in the management of patients with type 2 diabetes mellitusCobble Michael<p>Abstract</p> <p>The glucagon-like peptide-1 receptor (GLP-1R) agonists and dipeptidyl peptidase-4 (DPP-4) inhibitors have become important options for the management of patients with type 2 diabetes mellitus. While the GLP-1R agonists and DPP-4 inhibitors act on the incretin system to regulate glucose homeostasis, there are important clinical differences among the five agents currently available in the U.S. For example, the GLP-1R agonists require subcutaneous administration, produce pharmacological levels of GLP-1 activity, promote weight loss, have a more robust glucose-lowering effect, and have a higher incidence of adverse gastrointestinal effects. In contrast, the DPP-4 inhibitors are taken orally, increase the half-life of endogenous GLP-1, are weight neutral, and are more commonly associated with nasopharyngitis. Differences in efficacy, safety, tolerability, and cost among the incretin-based therapies are important to consider in the primary care management of patients with type 2 diabetes mellitus.</p>http://www.dmsjournal.com/content/4/1/8type 2 diabetesexenatideliraglutidesitagliptinsaxagliptinlinagliptinefficacysafety |
spellingShingle | Cobble Michael Differentiating among incretin-based therapies in the management of patients with type 2 diabetes mellitus Diabetology & Metabolic Syndrome type 2 diabetes exenatide liraglutide sitagliptin saxagliptin linagliptin efficacy safety |
title | Differentiating among incretin-based therapies in the management of patients with type 2 diabetes mellitus |
title_full | Differentiating among incretin-based therapies in the management of patients with type 2 diabetes mellitus |
title_fullStr | Differentiating among incretin-based therapies in the management of patients with type 2 diabetes mellitus |
title_full_unstemmed | Differentiating among incretin-based therapies in the management of patients with type 2 diabetes mellitus |
title_short | Differentiating among incretin-based therapies in the management of patients with type 2 diabetes mellitus |
title_sort | differentiating among incretin based therapies in the management of patients with type 2 diabetes mellitus |
topic | type 2 diabetes exenatide liraglutide sitagliptin saxagliptin linagliptin efficacy safety |
url | http://www.dmsjournal.com/content/4/1/8 |
work_keys_str_mv | AT cobblemichael differentiatingamongincretinbasedtherapiesinthemanagementofpatientswithtype2diabetesmellitus |