Vitamin D is not required for adaptive immunity to listeria
Abstract Although ex vivo research suggests that vitamin D may play a role in innate and adaptive immunity, clear in vivo evidence is lacking. We have tested whether severe vitamin D deficiency alters the ability of mice to resist infection by Listeria. Our results show that vitamin D deficiency doe...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2019-08-01
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| Series: | Physiological Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.14814/phy2.14209 |
| _version_ | 1818187804620881920 |
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| author | Gary A. Baisa Lori Plum Steve Marling Jeremy Seeman Hector F. DeLuca |
| author_facet | Gary A. Baisa Lori Plum Steve Marling Jeremy Seeman Hector F. DeLuca |
| author_sort | Gary A. Baisa |
| collection | DOAJ |
| description | Abstract Although ex vivo research suggests that vitamin D may play a role in innate and adaptive immunity, clear in vivo evidence is lacking. We have tested whether severe vitamin D deficiency alters the ability of mice to resist infection by Listeria. Our results show that vitamin D deficiency does not affect the LD50 of naïve mice in response to Listeria. To study the adaptive immune response, the LD50 for Listeria‐immunized mice was determined for vitamin D‐deficient and vitamin D‐sufficient mice. Although the LD50 clearly increased by immunization with inactivated Listeria, there was no effect of vitamin D deficiency on survival of mice infected with wild‐type Listeria. Thus, in this model of adaptive immunity, we could find no evidence of a role for vitamin D. |
| first_indexed | 2024-12-11T23:16:51Z |
| format | Article |
| id | doaj.art-e08a61cc2ceb4811a910f4c47bfe264a |
| institution | Directory Open Access Journal |
| issn | 2051-817X |
| language | English |
| last_indexed | 2024-12-11T23:16:51Z |
| publishDate | 2019-08-01 |
| publisher | Wiley |
| record_format | Article |
| series | Physiological Reports |
| spelling | doaj.art-e08a61cc2ceb4811a910f4c47bfe264a2022-12-22T00:46:30ZengWileyPhysiological Reports2051-817X2019-08-01716n/an/a10.14814/phy2.14209Vitamin D is not required for adaptive immunity to listeriaGary A. Baisa0Lori Plum1Steve Marling2Jeremy Seeman3Hector F. DeLuca4Department of Biochemistry University of Wisconsin‐Madison Madison WisconsinDepartment of Biochemistry University of Wisconsin‐Madison Madison WisconsinDepartment of Biochemistry University of Wisconsin‐Madison Madison WisconsinDiasorin Inc. Stillwater MinnesotaDepartment of Biochemistry University of Wisconsin‐Madison Madison WisconsinAbstract Although ex vivo research suggests that vitamin D may play a role in innate and adaptive immunity, clear in vivo evidence is lacking. We have tested whether severe vitamin D deficiency alters the ability of mice to resist infection by Listeria. Our results show that vitamin D deficiency does not affect the LD50 of naïve mice in response to Listeria. To study the adaptive immune response, the LD50 for Listeria‐immunized mice was determined for vitamin D‐deficient and vitamin D‐sufficient mice. Although the LD50 clearly increased by immunization with inactivated Listeria, there was no effect of vitamin D deficiency on survival of mice infected with wild‐type Listeria. Thus, in this model of adaptive immunity, we could find no evidence of a role for vitamin D.https://doi.org/10.14814/phy2.14209Vitamin D |
| spellingShingle | Gary A. Baisa Lori Plum Steve Marling Jeremy Seeman Hector F. DeLuca Vitamin D is not required for adaptive immunity to listeria Physiological Reports Vitamin D |
| title | Vitamin D is not required for adaptive immunity to listeria |
| title_full | Vitamin D is not required for adaptive immunity to listeria |
| title_fullStr | Vitamin D is not required for adaptive immunity to listeria |
| title_full_unstemmed | Vitamin D is not required for adaptive immunity to listeria |
| title_short | Vitamin D is not required for adaptive immunity to listeria |
| title_sort | vitamin d is not required for adaptive immunity to listeria |
| topic | Vitamin D |
| url | https://doi.org/10.14814/phy2.14209 |
| work_keys_str_mv | AT garyabaisa vitamindisnotrequiredforadaptiveimmunitytolisteria AT loriplum vitamindisnotrequiredforadaptiveimmunitytolisteria AT stevemarling vitamindisnotrequiredforadaptiveimmunitytolisteria AT jeremyseeman vitamindisnotrequiredforadaptiveimmunitytolisteria AT hectorfdeluca vitamindisnotrequiredforadaptiveimmunitytolisteria |