Actinobacteria Derived from Algerian Ecosystems as a Prominent Source of Antimicrobial Molecules
Actinobacteria, in particular “rare actinobacteria” isolated from extreme ecosystems, remain the most inexhaustible source of novel antimicrobials, offering a chance to discover new bioactive metabolites. This is the first overview on actinobacteria isolated in Algeria since 2002...
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| Format: | Article |
| Language: | English |
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MDPI AG
2019-10-01
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| Series: | Antibiotics |
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| Online Access: | https://www.mdpi.com/2079-6382/8/4/172 |
| _version_ | 1818190137465503744 |
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| author | Ibtissem Djinni Andrea Defant Mouloud Kecha Ines Mancini |
| author_facet | Ibtissem Djinni Andrea Defant Mouloud Kecha Ines Mancini |
| author_sort | Ibtissem Djinni |
| collection | DOAJ |
| description | Actinobacteria, in particular “rare actinobacteria” isolated from extreme ecosystems, remain the most inexhaustible source of novel antimicrobials, offering a chance to discover new bioactive metabolites. This is the first overview on actinobacteria isolated in Algeria since 2002 to date with the aim to present their potential in producing bioactive secondary metabolites. Twenty-nine new species and one novel genus have been isolated, mainly from the Saharan soil and palm groves, where 37.93% of the most abundant genera belong to <i>Saccharothrix</i> and <i>Actinopolyspora</i>. Several of these strains were found to produce antibiotics and antifungal metabolites, including 17 new molecules among the 50 structures reported, and some of these antibacterial metabolites have shown interesting antitumor activities. A series of approaches used to enhance the production of bioactive compounds is also presented as the manipulation of culture media by both classical methods and modeling designs through statistical strategies and the associations with diverse organisms and strains. Focusing on the Algerian natural sources of antimicrobial metabolites, this work is a representative example of the potential of a closely combined study on biology and chemistry of natural products. |
| first_indexed | 2024-12-11T23:53:56Z |
| format | Article |
| id | doaj.art-e08abaa003984e63b567b5390a7598af |
| institution | Directory Open Access Journal |
| issn | 2079-6382 |
| language | English |
| last_indexed | 2024-12-11T23:53:56Z |
| publishDate | 2019-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antibiotics |
| spelling | doaj.art-e08abaa003984e63b567b5390a7598af2022-12-22T00:45:24ZengMDPI AGAntibiotics2079-63822019-10-018417210.3390/antibiotics8040172antibiotics8040172Actinobacteria Derived from Algerian Ecosystems as a Prominent Source of Antimicrobial MoleculesIbtissem Djinni0Andrea Defant1Mouloud Kecha2Ines Mancini3Laboratoire de Microbiologie Appliquée, Faculté des Sciences de la Nature et de la Vie, Université de Bejaia, Targa Ouzemmour 06000, AlgeriaBioorganic Chemistry Laboratory, Department of Physics, University of Trento, 38123 Trento, ItalyLaboratoire de Microbiologie Appliquée, Faculté des Sciences de la Nature et de la Vie, Université de Bejaia, Targa Ouzemmour 06000, AlgeriaBioorganic Chemistry Laboratory, Department of Physics, University of Trento, 38123 Trento, ItalyActinobacteria, in particular “rare actinobacteria” isolated from extreme ecosystems, remain the most inexhaustible source of novel antimicrobials, offering a chance to discover new bioactive metabolites. This is the first overview on actinobacteria isolated in Algeria since 2002 to date with the aim to present their potential in producing bioactive secondary metabolites. Twenty-nine new species and one novel genus have been isolated, mainly from the Saharan soil and palm groves, where 37.93% of the most abundant genera belong to <i>Saccharothrix</i> and <i>Actinopolyspora</i>. Several of these strains were found to produce antibiotics and antifungal metabolites, including 17 new molecules among the 50 structures reported, and some of these antibacterial metabolites have shown interesting antitumor activities. A series of approaches used to enhance the production of bioactive compounds is also presented as the manipulation of culture media by both classical methods and modeling designs through statistical strategies and the associations with diverse organisms and strains. Focusing on the Algerian natural sources of antimicrobial metabolites, this work is a representative example of the potential of a closely combined study on biology and chemistry of natural products.https://www.mdpi.com/2079-6382/8/4/172actinobacteriaantimicrobialantibioticantifungalsecondary metaboliteschemodiversityrare actinobacteriasaharan ecosystem |
| spellingShingle | Ibtissem Djinni Andrea Defant Mouloud Kecha Ines Mancini Actinobacteria Derived from Algerian Ecosystems as a Prominent Source of Antimicrobial Molecules Antibiotics actinobacteria antimicrobial antibiotic antifungal secondary metabolites chemodiversity rare actinobacteria saharan ecosystem |
| title | Actinobacteria Derived from Algerian Ecosystems as a Prominent Source of Antimicrobial Molecules |
| title_full | Actinobacteria Derived from Algerian Ecosystems as a Prominent Source of Antimicrobial Molecules |
| title_fullStr | Actinobacteria Derived from Algerian Ecosystems as a Prominent Source of Antimicrobial Molecules |
| title_full_unstemmed | Actinobacteria Derived from Algerian Ecosystems as a Prominent Source of Antimicrobial Molecules |
| title_short | Actinobacteria Derived from Algerian Ecosystems as a Prominent Source of Antimicrobial Molecules |
| title_sort | actinobacteria derived from algerian ecosystems as a prominent source of antimicrobial molecules |
| topic | actinobacteria antimicrobial antibiotic antifungal secondary metabolites chemodiversity rare actinobacteria saharan ecosystem |
| url | https://www.mdpi.com/2079-6382/8/4/172 |
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