Application of CRISPR-Cas system in the diagnosis and therapy of ESKAPE infections
Antimicrobial-resistant ESKAPE (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter species) pathogens represent a global threat to human health. ESKAPE pathogens are the most common opportunistic pathogens in nosocomi...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-08-01
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| Series: | Frontiers in Cellular and Infection Microbiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcimb.2023.1223696/full |
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| author | Yizheng Qian Yizheng Qian Dapeng Zhou Dapeng Zhou Dapeng Zhou Min Li Min Li Yongxiang Zhao Yongxiang Zhao Huanhuan Liu Huanhuan Liu Li Yang Li Yang Zhiqin Ying Zhiqin Ying Guangtao Huang Guangtao Huang Guangtao Huang |
| author_facet | Yizheng Qian Yizheng Qian Dapeng Zhou Dapeng Zhou Dapeng Zhou Min Li Min Li Yongxiang Zhao Yongxiang Zhao Huanhuan Liu Huanhuan Liu Li Yang Li Yang Zhiqin Ying Zhiqin Ying Guangtao Huang Guangtao Huang Guangtao Huang |
| author_sort | Yizheng Qian |
| collection | DOAJ |
| description | Antimicrobial-resistant ESKAPE (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter species) pathogens represent a global threat to human health. ESKAPE pathogens are the most common opportunistic pathogens in nosocomial infections, and a considerable number of their clinical isolates are not susceptible to conventional antimicrobial therapy. Therefore, innovative therapeutic strategies that can effectively deal with ESKAPE pathogens will bring huge social and economic benefits and ease the suffering of tens of thousands of patients. Among these strategies, CRISPR (clustered regularly interspaced short palindromic repeats) system has received extra attention due to its high specificity. Regrettably, there is currently no direct CRISPR-system-based anti-infective treatment. This paper reviews the applications of CRISPR-Cas system in the study of ESKAPE pathogens, aiming to provide directions for the research of ideal new drugs and provide a reference for solving a series of problems caused by multidrug-resistant bacteria (MDR) in the post-antibiotic era. However, most research is still far from clinical application. |
| first_indexed | 2024-03-12T14:25:45Z |
| format | Article |
| id | doaj.art-e08bc9a0fc4a44c7b09fcbacdc6eb1b5 |
| institution | Directory Open Access Journal |
| issn | 2235-2988 |
| language | English |
| last_indexed | 2024-03-12T14:25:45Z |
| publishDate | 2023-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular and Infection Microbiology |
| spelling | doaj.art-e08bc9a0fc4a44c7b09fcbacdc6eb1b52023-08-18T07:55:21ZengFrontiers Media S.A.Frontiers in Cellular and Infection Microbiology2235-29882023-08-011310.3389/fcimb.2023.12236961223696Application of CRISPR-Cas system in the diagnosis and therapy of ESKAPE infectionsYizheng Qian0Yizheng Qian1Dapeng Zhou2Dapeng Zhou3Dapeng Zhou4Min Li5Min Li6Yongxiang Zhao7Yongxiang Zhao8Huanhuan Liu9Huanhuan Liu10Li Yang11Li Yang12Zhiqin Ying13Zhiqin Ying14Guangtao Huang15Guangtao Huang16Guangtao Huang17Department of Burns and Plastic Surgery, Affiliated Hospital of Zunyi Medical University, Zunyi, ChinaThe Collaborative Innovation Center of Tissue Damage Repair and Regeneration Medicine of Zunyi Medical University, Zunyi, ChinaDepartment of Burns and Plastic Surgery, Affiliated Hospital of Zunyi Medical University, Zunyi, ChinaThe Collaborative Innovation Center of Tissue Damage Repair and Regeneration Medicine of Zunyi Medical University, Zunyi, ChinaDepartment of Burn Plastic and Wound Repair Surgery, The Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, ChinaDepartment of Burns and Plastic Surgery, Affiliated Hospital of Zunyi Medical University, Zunyi, ChinaThe Collaborative Innovation Center of Tissue Damage Repair and Regeneration Medicine of Zunyi Medical University, Zunyi, ChinaDepartment of Burns and Plastic Surgery, Affiliated Hospital of Zunyi Medical University, Zunyi, ChinaThe Collaborative Innovation Center of Tissue Damage Repair and Regeneration Medicine of Zunyi Medical University, Zunyi, ChinaDepartment of Burns and Plastic Surgery, Affiliated Hospital of Zunyi Medical University, Zunyi, ChinaThe Collaborative Innovation Center of Tissue Damage Repair and Regeneration Medicine of Zunyi Medical University, Zunyi, ChinaDepartment of Burns and Plastic Surgery, Affiliated Hospital of Zunyi Medical University, Zunyi, ChinaThe Collaborative Innovation Center of Tissue Damage Repair and Regeneration Medicine of Zunyi Medical University, Zunyi, ChinaDepartment of Burns and Plastic Surgery, Affiliated Hospital of Zunyi Medical University, Zunyi, ChinaThe Collaborative Innovation Center of Tissue Damage Repair and Regeneration Medicine of Zunyi Medical University, Zunyi, ChinaDepartment of Burns and Plastic Surgery, Affiliated Hospital of Zunyi Medical University, Zunyi, ChinaThe Collaborative Innovation Center of Tissue Damage Repair and Regeneration Medicine of Zunyi Medical University, Zunyi, ChinaDepartment of Burn and Plastic Surgery, Department of Wound Repair, Shenzhen Institute of Translational Medicine, The First Affiliated Hospital of Shenzhen University, Shenzhen Second People’s Hospital, Shenzhen, ChinaAntimicrobial-resistant ESKAPE (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter species) pathogens represent a global threat to human health. ESKAPE pathogens are the most common opportunistic pathogens in nosocomial infections, and a considerable number of their clinical isolates are not susceptible to conventional antimicrobial therapy. Therefore, innovative therapeutic strategies that can effectively deal with ESKAPE pathogens will bring huge social and economic benefits and ease the suffering of tens of thousands of patients. Among these strategies, CRISPR (clustered regularly interspaced short palindromic repeats) system has received extra attention due to its high specificity. Regrettably, there is currently no direct CRISPR-system-based anti-infective treatment. This paper reviews the applications of CRISPR-Cas system in the study of ESKAPE pathogens, aiming to provide directions for the research of ideal new drugs and provide a reference for solving a series of problems caused by multidrug-resistant bacteria (MDR) in the post-antibiotic era. However, most research is still far from clinical application.https://www.frontiersin.org/articles/10.3389/fcimb.2023.1223696/fullCRISPR-CasESKAPEpathogeninfectiondiagnosistherapy |
| spellingShingle | Yizheng Qian Yizheng Qian Dapeng Zhou Dapeng Zhou Dapeng Zhou Min Li Min Li Yongxiang Zhao Yongxiang Zhao Huanhuan Liu Huanhuan Liu Li Yang Li Yang Zhiqin Ying Zhiqin Ying Guangtao Huang Guangtao Huang Guangtao Huang Application of CRISPR-Cas system in the diagnosis and therapy of ESKAPE infections Frontiers in Cellular and Infection Microbiology CRISPR-Cas ESKAPE pathogen infection diagnosis therapy |
| title | Application of CRISPR-Cas system in the diagnosis and therapy of ESKAPE infections |
| title_full | Application of CRISPR-Cas system in the diagnosis and therapy of ESKAPE infections |
| title_fullStr | Application of CRISPR-Cas system in the diagnosis and therapy of ESKAPE infections |
| title_full_unstemmed | Application of CRISPR-Cas system in the diagnosis and therapy of ESKAPE infections |
| title_short | Application of CRISPR-Cas system in the diagnosis and therapy of ESKAPE infections |
| title_sort | application of crispr cas system in the diagnosis and therapy of eskape infections |
| topic | CRISPR-Cas ESKAPE pathogen infection diagnosis therapy |
| url | https://www.frontiersin.org/articles/10.3389/fcimb.2023.1223696/full |
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