Prognostic significance of eighth edition TNM stage criteria in combined small-cell lung cancer
ObjectivesThis study aimed to evaluate the prognostic significance of the eighth edition TNM stage criteria in patients with combined small-cell lung cancer (C-SCLC) on a population level.MethodsUsing the Surveillance, Epidemiology, and End Results (SEER) database, patients diagnosed with C-SCLC (hi...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-03-01
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| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2023.1018288/full |
| _version_ | 1811158344838152192 |
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| author | Ziran Zhao Yibo Gao Fengwei Tan Qi Xue Shugeng Gao Jie He |
| author_facet | Ziran Zhao Yibo Gao Fengwei Tan Qi Xue Shugeng Gao Jie He |
| author_sort | Ziran Zhao |
| collection | DOAJ |
| description | ObjectivesThis study aimed to evaluate the prognostic significance of the eighth edition TNM stage criteria in patients with combined small-cell lung cancer (C-SCLC) on a population level.MethodsUsing the Surveillance, Epidemiology, and End Results (SEER) database, patients diagnosed with C-SCLC (histology code 8245) between the years 2004 and 2015 were identified. We performed a Kaplan–Meier analysis and used the multivariable cox regression proportional hazards model to obtain prognostic overall survival estimates for each group of patients.ResultsA total of 477 patients diagnosed with C-SCLC were identified. The T, N, M, TNM, and combined TNM stage status of the eighth edition were all significant prognostic factors for patients’ overall survivals, with the best discrimination identified in the combined stages. Surgery was also found to be a prognostic factor (HR =1.95, 95%CI =1.49-2.56, p<0.01) for patients with C-SCLC.ConclusionsThe combined eighth edition of the TNM staging criteria shows reliable prognostic significance in patients with C-SCLC. Moreover, surgery might be significant for improving the patients’ prognosis. |
| first_indexed | 2024-04-10T05:22:57Z |
| format | Article |
| id | doaj.art-e08c249529254a578d70949f6d1bee2a |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-04-10T05:22:57Z |
| publishDate | 2023-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-e08c249529254a578d70949f6d1bee2a2023-03-08T06:55:30ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2023-03-011310.3389/fonc.2023.10182881018288Prognostic significance of eighth edition TNM stage criteria in combined small-cell lung cancerZiran ZhaoYibo GaoFengwei TanQi XueShugeng GaoJie HeObjectivesThis study aimed to evaluate the prognostic significance of the eighth edition TNM stage criteria in patients with combined small-cell lung cancer (C-SCLC) on a population level.MethodsUsing the Surveillance, Epidemiology, and End Results (SEER) database, patients diagnosed with C-SCLC (histology code 8245) between the years 2004 and 2015 were identified. We performed a Kaplan–Meier analysis and used the multivariable cox regression proportional hazards model to obtain prognostic overall survival estimates for each group of patients.ResultsA total of 477 patients diagnosed with C-SCLC were identified. The T, N, M, TNM, and combined TNM stage status of the eighth edition were all significant prognostic factors for patients’ overall survivals, with the best discrimination identified in the combined stages. Surgery was also found to be a prognostic factor (HR =1.95, 95%CI =1.49-2.56, p<0.01) for patients with C-SCLC.ConclusionsThe combined eighth edition of the TNM staging criteria shows reliable prognostic significance in patients with C-SCLC. Moreover, surgery might be significant for improving the patients’ prognosis.https://www.frontiersin.org/articles/10.3389/fonc.2023.1018288/fullcombined small cell lung cancer (c-SCLC)8th TNM stage criteriaprognostic significanceSEER databasesurgery |
| spellingShingle | Ziran Zhao Yibo Gao Fengwei Tan Qi Xue Shugeng Gao Jie He Prognostic significance of eighth edition TNM stage criteria in combined small-cell lung cancer Frontiers in Oncology combined small cell lung cancer (c-SCLC) 8th TNM stage criteria prognostic significance SEER database surgery |
| title | Prognostic significance of eighth edition TNM stage criteria in combined small-cell lung cancer |
| title_full | Prognostic significance of eighth edition TNM stage criteria in combined small-cell lung cancer |
| title_fullStr | Prognostic significance of eighth edition TNM stage criteria in combined small-cell lung cancer |
| title_full_unstemmed | Prognostic significance of eighth edition TNM stage criteria in combined small-cell lung cancer |
| title_short | Prognostic significance of eighth edition TNM stage criteria in combined small-cell lung cancer |
| title_sort | prognostic significance of eighth edition tnm stage criteria in combined small cell lung cancer |
| topic | combined small cell lung cancer (c-SCLC) 8th TNM stage criteria prognostic significance SEER database surgery |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2023.1018288/full |
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