The role of perfluorooctane sulfonic acid (PFOS) exposure in inflammation of intestinal tissues and intestinal carcinogenesis
PFAS (per- and polyfluoroalkyl substances) are organofluorine substances that are used commercially in products like non-stick cookware, food packaging, personal care products, fire-fighting foam, etc. These chemicals have several different subtypes made of varying numbers of carbon and fluorine ato...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-08-01
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| Series: | Frontiers in Toxicology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/ftox.2023.1244457/full |
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| author | Jerika Durham Josiane Weber Tessmann Pan Deng Bernhard Hennig Yekaterina Y. Zaytseva |
| author_facet | Jerika Durham Josiane Weber Tessmann Pan Deng Bernhard Hennig Yekaterina Y. Zaytseva |
| author_sort | Jerika Durham |
| collection | DOAJ |
| description | PFAS (per- and polyfluoroalkyl substances) are organofluorine substances that are used commercially in products like non-stick cookware, food packaging, personal care products, fire-fighting foam, etc. These chemicals have several different subtypes made of varying numbers of carbon and fluorine atoms. PFAS substances that have longer carbon chains, such as PFOS (perfluorooctane sulfonic acid), can potentially pose a significant public health risk due to their ability to bioaccumulate and persist for long periods of time in the body and the environment. The National Academies Report suggests there is some evidence of PFOS exposure and gastrointestinal (GI) inflammation contributing to ulcerative colitis. Inflammatory bowel diseases such as ulcerative colitis are precursors to colorectal cancer. However, evidence about the association between PFOS and colorectal cancer is limited and has shown contradictory findings. This review provides an overview of population and preclinical studies on PFOS exposure and GI inflammation, metabolism, immune responses, and carcinogenesis. It also highlights some mitigation approaches to reduce the harmful effects of PFOS on GI tract and discusses the dietary strategies, such as an increase in soluble fiber intake, to reduce PFOS-induced alterations in cellular lipid metabolism. More importantly, this review demonstrates the urgent need to better understand the relationship between PFOS and GI pathology and carcinogenesis, which will enable development of better approaches for interventions in populations exposed to high levels of PFAS, and in particular to PFOS. |
| first_indexed | 2024-03-12T14:38:36Z |
| format | Article |
| id | doaj.art-e08ca699275a4fc5ad02d63ef5901f18 |
| institution | Directory Open Access Journal |
| issn | 2673-3080 |
| language | English |
| last_indexed | 2024-03-12T14:38:36Z |
| publishDate | 2023-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Toxicology |
| spelling | doaj.art-e08ca699275a4fc5ad02d63ef5901f182023-08-16T23:35:08ZengFrontiers Media S.A.Frontiers in Toxicology2673-30802023-08-01510.3389/ftox.2023.12444571244457The role of perfluorooctane sulfonic acid (PFOS) exposure in inflammation of intestinal tissues and intestinal carcinogenesisJerika Durham0Josiane Weber Tessmann1Pan Deng2Bernhard Hennig3Yekaterina Y. Zaytseva4Department of Toxicology and Cancer Biology, University of Kentucky, Lexington, KY, United StatesDepartment of Toxicology and Cancer Biology, University of Kentucky, Lexington, KY, United StatesCollege of Pharmaceutical Sciences, Soochow University, Suzhou, ChinaDepartment of Animal and Food Sciences, University of Kentucky, Lexington, KY, United StatesDepartment of Toxicology and Cancer Biology, University of Kentucky, Lexington, KY, United StatesPFAS (per- and polyfluoroalkyl substances) are organofluorine substances that are used commercially in products like non-stick cookware, food packaging, personal care products, fire-fighting foam, etc. These chemicals have several different subtypes made of varying numbers of carbon and fluorine atoms. PFAS substances that have longer carbon chains, such as PFOS (perfluorooctane sulfonic acid), can potentially pose a significant public health risk due to their ability to bioaccumulate and persist for long periods of time in the body and the environment. The National Academies Report suggests there is some evidence of PFOS exposure and gastrointestinal (GI) inflammation contributing to ulcerative colitis. Inflammatory bowel diseases such as ulcerative colitis are precursors to colorectal cancer. However, evidence about the association between PFOS and colorectal cancer is limited and has shown contradictory findings. This review provides an overview of population and preclinical studies on PFOS exposure and GI inflammation, metabolism, immune responses, and carcinogenesis. It also highlights some mitigation approaches to reduce the harmful effects of PFOS on GI tract and discusses the dietary strategies, such as an increase in soluble fiber intake, to reduce PFOS-induced alterations in cellular lipid metabolism. More importantly, this review demonstrates the urgent need to better understand the relationship between PFOS and GI pathology and carcinogenesis, which will enable development of better approaches for interventions in populations exposed to high levels of PFAS, and in particular to PFOS.https://www.frontiersin.org/articles/10.3389/ftox.2023.1244457/fullper- and polyfluoroalkyl substances (PFAS)perfluorooctane sulfonic acid (PFOS)ulcerative colitisgastrointestinal tractcolorectal cancer |
| spellingShingle | Jerika Durham Josiane Weber Tessmann Pan Deng Bernhard Hennig Yekaterina Y. Zaytseva The role of perfluorooctane sulfonic acid (PFOS) exposure in inflammation of intestinal tissues and intestinal carcinogenesis Frontiers in Toxicology per- and polyfluoroalkyl substances (PFAS) perfluorooctane sulfonic acid (PFOS) ulcerative colitis gastrointestinal tract colorectal cancer |
| title | The role of perfluorooctane sulfonic acid (PFOS) exposure in inflammation of intestinal tissues and intestinal carcinogenesis |
| title_full | The role of perfluorooctane sulfonic acid (PFOS) exposure in inflammation of intestinal tissues and intestinal carcinogenesis |
| title_fullStr | The role of perfluorooctane sulfonic acid (PFOS) exposure in inflammation of intestinal tissues and intestinal carcinogenesis |
| title_full_unstemmed | The role of perfluorooctane sulfonic acid (PFOS) exposure in inflammation of intestinal tissues and intestinal carcinogenesis |
| title_short | The role of perfluorooctane sulfonic acid (PFOS) exposure in inflammation of intestinal tissues and intestinal carcinogenesis |
| title_sort | role of perfluorooctane sulfonic acid pfos exposure in inflammation of intestinal tissues and intestinal carcinogenesis |
| topic | per- and polyfluoroalkyl substances (PFAS) perfluorooctane sulfonic acid (PFOS) ulcerative colitis gastrointestinal tract colorectal cancer |
| url | https://www.frontiersin.org/articles/10.3389/ftox.2023.1244457/full |
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