Resistance exercise training-induced skeletal muscle strength provides protective effects on high-fat-diet-induced metabolic stress in mice
Abstract Background Resistance exercise training is known to improve metabolic disorders, such as obesity and type2 diabetes. In this study, we investigated whether the beneficial effects of resistance exercise training persisted even after the discontinuation of training with high-fat diet (HFD)-in...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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BMC
2022-12-01
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| Series: | Laboratory Animal Research |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s42826-022-00145-0 |
| _version_ | 1797985581789085696 |
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| author | Hye Jin Kim Youn Ju Kim Il Yong Kim Je Kyung Seong |
| author_facet | Hye Jin Kim Youn Ju Kim Il Yong Kim Je Kyung Seong |
| author_sort | Hye Jin Kim |
| collection | DOAJ |
| description | Abstract Background Resistance exercise training is known to improve metabolic disorders, such as obesity and type2 diabetes. In this study, we investigated whether the beneficial effects of resistance exercise training persisted even after the discontinuation of training with high-fat diet (HFD)-induced metabolic stress. We further evaluated whether the improvement in skeletal muscle strength and endurance by training were correlated with improved metabolism. Eight-week-old male C57BL/6N mice were divided into groups that remained sedentary or had access to daily resistance exercise via ladder climbing for 8 weeks. Trained and untrained mice were fed an HFD for 1 week after the exercise training intervention (n = 5–8 per group). Results Resistance exercise-trained mice had a lean phenotype and counteracted diet-induced obesity and glucose tolerance, even after exercise cessation. Grip strength was significantly inversely correlated with the body weight, fat mass, and glucose tolerance. However, hanging time was significantly inversely correlated with body weight only. Conclusions These results have strong implications for the preventive effect of resistance exercise-induced metabolic improvement by enhancing skeletal muscle strength rather than endurance. |
| first_indexed | 2024-04-11T07:20:23Z |
| format | Article |
| id | doaj.art-e08cf808e65a4275b59b97df54d1a217 |
| institution | Directory Open Access Journal |
| issn | 2233-7660 |
| language | English |
| last_indexed | 2024-04-11T07:20:23Z |
| publishDate | 2022-12-01 |
| publisher | BMC |
| record_format | Article |
| series | Laboratory Animal Research |
| spelling | doaj.art-e08cf808e65a4275b59b97df54d1a2172022-12-22T04:37:48ZengBMCLaboratory Animal Research2233-76602022-12-0138111010.1186/s42826-022-00145-0Resistance exercise training-induced skeletal muscle strength provides protective effects on high-fat-diet-induced metabolic stress in miceHye Jin Kim0Youn Ju Kim1Il Yong Kim2Je Kyung Seong3Laboratory of Developmental Biology and Genomics, College of Veterinary Medicine, Seoul National UniversityLaboratory of Developmental Biology and Genomics, College of Veterinary Medicine, Seoul National UniversityLaboratory of Developmental Biology and Genomics, College of Veterinary Medicine, Seoul National UniversityLaboratory of Developmental Biology and Genomics, College of Veterinary Medicine, Seoul National UniversityAbstract Background Resistance exercise training is known to improve metabolic disorders, such as obesity and type2 diabetes. In this study, we investigated whether the beneficial effects of resistance exercise training persisted even after the discontinuation of training with high-fat diet (HFD)-induced metabolic stress. We further evaluated whether the improvement in skeletal muscle strength and endurance by training were correlated with improved metabolism. Eight-week-old male C57BL/6N mice were divided into groups that remained sedentary or had access to daily resistance exercise via ladder climbing for 8 weeks. Trained and untrained mice were fed an HFD for 1 week after the exercise training intervention (n = 5–8 per group). Results Resistance exercise-trained mice had a lean phenotype and counteracted diet-induced obesity and glucose tolerance, even after exercise cessation. Grip strength was significantly inversely correlated with the body weight, fat mass, and glucose tolerance. However, hanging time was significantly inversely correlated with body weight only. Conclusions These results have strong implications for the preventive effect of resistance exercise-induced metabolic improvement by enhancing skeletal muscle strength rather than endurance.https://doi.org/10.1186/s42826-022-00145-0Resistance exerciseSkeletal muscleObesityInsulin sensitivityHigh-fat diet |
| spellingShingle | Hye Jin Kim Youn Ju Kim Il Yong Kim Je Kyung Seong Resistance exercise training-induced skeletal muscle strength provides protective effects on high-fat-diet-induced metabolic stress in mice Laboratory Animal Research Resistance exercise Skeletal muscle Obesity Insulin sensitivity High-fat diet |
| title | Resistance exercise training-induced skeletal muscle strength provides protective effects on high-fat-diet-induced metabolic stress in mice |
| title_full | Resistance exercise training-induced skeletal muscle strength provides protective effects on high-fat-diet-induced metabolic stress in mice |
| title_fullStr | Resistance exercise training-induced skeletal muscle strength provides protective effects on high-fat-diet-induced metabolic stress in mice |
| title_full_unstemmed | Resistance exercise training-induced skeletal muscle strength provides protective effects on high-fat-diet-induced metabolic stress in mice |
| title_short | Resistance exercise training-induced skeletal muscle strength provides protective effects on high-fat-diet-induced metabolic stress in mice |
| title_sort | resistance exercise training induced skeletal muscle strength provides protective effects on high fat diet induced metabolic stress in mice |
| topic | Resistance exercise Skeletal muscle Obesity Insulin sensitivity High-fat diet |
| url | https://doi.org/10.1186/s42826-022-00145-0 |
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