Paracoccidioidomicose em um adolescente imunocompetente: uma doença negligenciada
Acute Paracoccidioidomycosis (PCM) represents 5 to 10% of total PCM cases. The estimated incidence varies between 1-4 cases for 100.000 inhabitants in the endemic regions of Brazil. It is known that PCM can coexist with other systemic mycoses such as Histoplasmosis. We report a case of a 10-year-old...
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| Format: | Article |
| Language: | English |
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Sociedade Brasileira de Pediatria
2023-12-01
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| Series: | Residência Pediátrica |
| Subjects: | |
| Online Access: | https://cdn.publisher.gn1.link/residenciapediatrica.com.br/pdf/v13n4aop682.pdf |
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| author | Aléxia Alves Cabral Cecília Pereira Silva Maria Cristina Carvalho do Espírito Santo Denise A. Castro Tainá Barros Ventura Rafael Pereira Silva Naiany Campos Rego |
| author_facet | Aléxia Alves Cabral Cecília Pereira Silva Maria Cristina Carvalho do Espírito Santo Denise A. Castro Tainá Barros Ventura Rafael Pereira Silva Naiany Campos Rego |
| author_sort | Aléxia Alves Cabral |
| collection | DOAJ |
| description | Acute Paracoccidioidomycosis (PCM) represents 5 to 10% of total PCM cases. The estimated incidence varies between 1-4 cases for 100.000 inhabitants in the endemic regions of Brazil. It is known that PCM can coexist with other systemic mycoses such as Histoplasmosis. We report a case of a 10-year-old adolescent from Barra Mansa, RJ, Brazil. He was hospitalized after recurrent visits to the emergency department for approximately one month, presenting with non-bloody diarrhea, weight-loss of 6kg in six weeks, dry cough and nocturnal fever (average temperature 38ºC). Counterimmunoelectrophoresis and lymph node biopsy were positive for Paracoccidioides brasiliensis. The treatment consisted of Amphotericin B IV 0,6 mg/kg of body weight per day for 10 days and Itraconazole PO 200mg per day for 12 months. After 5 years, the patient remains asymptomatic. Reports of similar cases are scant in the literature and, the few encountered, are of immunocompromised children. The incidence and prevalence estimation of PCM might be inaccurate due to underdiagnosis and under-reporting. |
| first_indexed | 2024-04-24T11:26:08Z |
| format | Article |
| id | doaj.art-e08de84829b743bdbae9b883b3eace24 |
| institution | Directory Open Access Journal |
| issn | 2236-6814 |
| language | English |
| last_indexed | 2024-04-24T11:26:08Z |
| publishDate | 2023-12-01 |
| publisher | Sociedade Brasileira de Pediatria |
| record_format | Article |
| series | Residência Pediátrica |
| spelling | doaj.art-e08de84829b743bdbae9b883b3eace242024-04-10T18:12:07ZengSociedade Brasileira de PediatriaResidência Pediátrica2236-68142023-12-0113410.25060/residpediatr-2023.v13n4-682Paracoccidioidomicose em um adolescente imunocompetente: uma doença negligenciadaAléxia Alves Cabral0Cecília Pereira Silva1Maria Cristina Carvalho do Espírito Santo2Denise A. Castro 3Tainá Barros Ventura4Rafael Pereira Silva5Naiany Campos Rego6Centro Universitário de Volta Redonda (UniFOA), Curso de Medicina - Volta Redonda - Rio de Janeiro - BrasilCentro Universitário de Volta Redonda (UniFOA), Pediatria - Volta Redonda - Rio de Janeiro - BrasilFaculdade de Medicina da Universidade de São Paulo (FMUSP), Departamento de Moléstias Infecciosas e Parasitárias, Laboratório de Imunopatologia da Esquistossomose - São Paulo - São Paulo - BrasilKingston Health Sciences Centre Queen’s University, Radiologia Pediátrica - Kingston - Ontário - CanadáHospital Municipal Dr. Munir Rafful, Residência de Pediatria - Volta Redonda - Rio de Janeiro - BrasilSecretaria Municipal de Saúde do Rio de Janeiro, Programa de Residência de Medicina de Família e Comunidade - Rio de Janeiro - Rio de Janeiro - BrasilAssociação de Medicina Intensiva Brasileira, Pós-graduação em Medicina Intensiva - São Paulo - São Paulo - BrasilAcute Paracoccidioidomycosis (PCM) represents 5 to 10% of total PCM cases. The estimated incidence varies between 1-4 cases for 100.000 inhabitants in the endemic regions of Brazil. It is known that PCM can coexist with other systemic mycoses such as Histoplasmosis. We report a case of a 10-year-old adolescent from Barra Mansa, RJ, Brazil. He was hospitalized after recurrent visits to the emergency department for approximately one month, presenting with non-bloody diarrhea, weight-loss of 6kg in six weeks, dry cough and nocturnal fever (average temperature 38ºC). Counterimmunoelectrophoresis and lymph node biopsy were positive for Paracoccidioides brasiliensis. The treatment consisted of Amphotericin B IV 0,6 mg/kg of body weight per day for 10 days and Itraconazole PO 200mg per day for 12 months. After 5 years, the patient remains asymptomatic. Reports of similar cases are scant in the literature and, the few encountered, are of immunocompromised children. The incidence and prevalence estimation of PCM might be inaccurate due to underdiagnosis and under-reporting.https://cdn.publisher.gn1.link/residenciapediatrica.com.br/pdf/v13n4aop682.pdfparacoccidioidomycosispediatricsimmunocompetenceadolescent |
| spellingShingle | Aléxia Alves Cabral Cecília Pereira Silva Maria Cristina Carvalho do Espírito Santo Denise A. Castro Tainá Barros Ventura Rafael Pereira Silva Naiany Campos Rego Paracoccidioidomicose em um adolescente imunocompetente: uma doença negligenciada Residência Pediátrica paracoccidioidomycosis pediatrics immunocompetence adolescent |
| title | Paracoccidioidomicose em um adolescente imunocompetente: uma doença negligenciada |
| title_full | Paracoccidioidomicose em um adolescente imunocompetente: uma doença negligenciada |
| title_fullStr | Paracoccidioidomicose em um adolescente imunocompetente: uma doença negligenciada |
| title_full_unstemmed | Paracoccidioidomicose em um adolescente imunocompetente: uma doença negligenciada |
| title_short | Paracoccidioidomicose em um adolescente imunocompetente: uma doença negligenciada |
| title_sort | paracoccidioidomicose em um adolescente imunocompetente uma doenca negligenciada |
| topic | paracoccidioidomycosis pediatrics immunocompetence adolescent |
| url | https://cdn.publisher.gn1.link/residenciapediatrica.com.br/pdf/v13n4aop682.pdf |
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