Assessment of Correlation between Dual-Energy Ct (De-Ct)-Derived Iodine Concentration and Local Flourodeoxyglucose (Fdg) Uptake in Patients with Primary Non-Small-Cell Lung Cancer
(1) The current literature contains several studies investigating the correlation between dual-energy-derived iodine concentration (IC) and positron emission tomography (PET)-derived Flourodeoxyglucose (<sup>18</sup>F-FDG) uptake in patients with non-small-cell lung cancer (NSCLC). In pr...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-07-01
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| Series: | Tomography |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2379-139X/8/4/149 |
| Summary: | (1) The current literature contains several studies investigating the correlation between dual-energy-derived iodine concentration (IC) and positron emission tomography (PET)-derived Flourodeoxyglucose (<sup>18</sup>F-FDG) uptake in patients with non-small-cell lung cancer (NSCLC). In previously published studies, either the entire tumor volume or a region of interest containing the maximum IC or <sup>18</sup>F-FDG was assessed. However, the results have been inconsistent. The objective of this study was to correlate IC with FDG both within the entire volume and regional sub-volumes of primary tumors in patients with NSCLC. (2) In this retrospective study, a total of 22 patients with NSCLC who underwent both dual-energy CT (DE-CT) and <sup>18</sup>F-FDG PET/CT were included. A region of interest (ROI) encircling the entire primary tumor was delineated, and a rigid registration of the DE-CT, iodine maps and FDG images was performed for the ROI. The correlation between tumor measurements and area-specific measurements of IC<sub>peak</sub> and the peak standardized uptake value (SUV<sub>peak</sub>) was found. Finally, a correlation between tumor volume and the distance between SUV<sub>peak</sub> and IC<sub>peak</sub> centroids was found. (3) For the entire tumor, moderate-to-strong correlations were found between SUV<sub>max</sub> and IC<sub>max</sub> (R = 0.62, <i>p</i> = 0.002), and metabolic tumor volume vs. total iodine content (R = 0.91, <i>p</i> < 0.001), respectively. For local tumor sub-volumes, a negative correlation was found between IC<sub>peak</sub> and SUV<sub>peak</sub> (R = −0.58, <i>p</i> = 0.0046). Furthermore, a strong correlation was found between the tumor volume and the distance in millimeters between SUV<sub>peak</sub> and IC<sub>peak</sub> centroids (R = 0.81, <i>p</i> < 0.0001). (4) In patients with NSCLC, high FDG uptakes and high DE-CT-derived iodine concentrations correlated on a whole-tumor level, but the peak areas were positioned at different locations within the tumor. <sup>18</sup>F-FDG PET/CT and DE-CT provide complementary information and might represent different underlying patho-physiologies. |
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| ISSN: | 2379-1381 2379-139X |