The HCMV gH/gL/UL128-131 complex triggers the specific cellular activation required for efficient viral internalization into target monocytes.

The HCMV gH/gL/UL128-131 complex triggers the specific cellular activation required for efficient viral internalization into target monocytes.

We have established that HCMV acts as a specific ligand engaging and activating cellular integrins on monocytes. As a result, integrin signaling via Src activation leads to the functional activation of paxillin required for efficient viral entry and for the biological changes in monocytes needed for...

Full description

Bibliographic Details
Main Authors:	Maciej T Nogalski, Gary C T Chan, Emily V Stevenson, Donna K Collins-McMillen, Andrew D Yurochko
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2013-01-01
Series:	PLoS Pathogens
Online Access:	http://europepmc.org/articles/PMC3708883?pdf=render

Similar Items

HCMV Reprogramming of Infected Monocyte Survival and Differentiation: A Goldilocks Phenomenon
by: Emily V. Stevenson, et al.
Published: (2014-02-01)

The murid herpesvirus-4 gH/gL binds to glycosaminoglycans.
by: Laurent Gillet, et al.
Published: (2008-02-01)

Antigenic Characterization of the HCMV gH/gL/gO and Pentamer Cell Entry Complexes Reveals Binding Sites for Potently Neutralizing Human Antibodies.
by: Claudio Ciferri, et al.
Published: (2015-10-01)

The Murid Herpesvirus-4 gL regulates an entry-associated conformation change in gH.
by: Laurent Gillet, et al.
Published: (2008-07-01)

Correction: The Murid Herpesvirus-4 gL Regulates an Entry-Associated Conformation Change in gH.
by: Laurent Gillet, et al.
Published: (2008-01-01)

Antibodies Targeting KSHV gH/gL Reveal Distinct Neutralization Mechanisms
by: Thomas Fricke, et al.
Published: (2022-03-01)

Human cytomegalovirus vaccine based on the envelope gH/gL pentamer complex.
by: Felix Wussow, et al.
Published: (2014-11-01)

Well Put Together—A Guide to Accessorizing with the Herpesvirus gH/gL Complexes
by: Gonzalo L. Gonzalez-Del Pino, et al.
Published: (2022-01-01)

Correction: The Murid Herpesvirus-4 gL Regulates an Entry-Associated Conformation Change in gH
Published: (2008-01-01)

Human Cytomegalovirus gH/gL Forms a Stable Complex with the Fusion Protein gB in Virions.
by: Adam L Vanarsdall, et al.
Published: (2016-04-01)

Human cytomegalovirus glycoprotein complex gH/gL/gO uses PDGFR-α as a key for entry.
by: Yiquan Wu, et al.
Published: (2017-04-01)

Species-Specific Inhibition of Necroptosis by HCMV UL36
by: Elena Muscolino, et al.
Published: (2021-10-01)

Non-redundant and redundant roles of cytomegalovirus gH/gL complexes in host organ entry and intra-tissue spread.
by: Niels A W Lemmermann, et al.
Published: (2015-02-01)

A neutralizing anti-gH/gL monoclonal antibody is protective in the guinea pig model of congenital CMV infection.
by: Marcy R Auerbach, et al.
Published: (2014-04-01)

Tetrameric glycoprotein complex gH/gL/gQ1/gQ2 is a promising vaccine candidate for human herpesvirus 6B.
by: Bochao Wang, et al.
Published: (2020-07-01)

Regulation of Herpes Simplex Virus gB-Induced Cell-Cell Fusion by Mutant Forms of gH/gL in the Absence of gD and Cellular Receptors
by: Doina Atanasiu, et al.
Published: (2013-05-01)

The Kaposi’s Sarcoma-Associated Herpesvirus (KSHV) gH/gL Complex Is the Predominant Neutralizing Antigenic Determinant in KSHV-Infected Individuals
by: Yasaman Mortazavi, et al.
Published: (2020-02-01)

Overview of how HCMV manipulation of host cell intracellular trafficking networks can promote productive infection
by: Bailey S. Mosher, et al.
Published: (2022-11-01)

Variants of HCMV <i>UL18</i> Sequenced Directly from Clinical Specimens Associate with Antibody and T-Cell Responses to HCMV
by: Shelley Waters, et al.
Published: (2022-10-01)

UPDG: <ul>U</ul>tilities package for data analysis of <ul>P</ul>ooled <ul>D</ul>NA <ul>G</ul>WAS
by: Ho Daniel WH, et al.
Published: (2012-01-01)

Identification of a short sequence in the HCMV terminase pUL56 essential for interaction with pUL89 subunit
by: G. Ligat, et al.
Published: (2017-08-01)

Novel mutations in UL24 and gH rescue efficient infection of an HSV vector retargeted to TrkA
by: Marco Marzulli, et al.
Published: (2023-09-01)

The Human Cytomegalovirus UL116 Glycoprotein Is a Chaperone to Control gH-Based Complexes Levels on Virions
by: Giacomo Vezzani, et al.
Published: (2021-04-01)

Low gH/gL (Sub)Species-Specific Antibody Levels Indicate Elephants at Risk of Fatal Elephant Endotheliotropic Herpesvirus Hemorrhagic Disease
by: Tabitha E. Hoornweg, et al.
Published: (2024-02-01)

Receptor Binding-Induced Conformational Changes in Herpes Simplex Virus Glycoprotein D Permit Interaction with the gH/gL Complex to Activate Fusion
by: Doina Atanasiu, et al.
Published: (2023-03-01)

A conserved Eph family receptor-binding motif on the gH/gL complex of Kaposi's sarcoma-associated herpesvirus and rhesus monkey rhadinovirus.
by: Anna K Großkopf, et al.
Published: (2018-02-01)

Two Sides to Every Story: Herpes Simplex Type-1 Viral Glycoproteins gB, gD, gH/gL, gK, and Cellular Receptors Function as Key Players in Membrane Fusion
by: Nithya Jambunathan, et al.
Published: (2021-09-01)

Complete protection of mice against lethal murine cytomegalovirus challenge by immunization with DNA vaccines encoding envelope glycoprotein complex III antigens gH, gL and gO.
by: Huadong Wang, et al.
Published: (2015-01-01)

Fibroblast, Epithelial and Endothelial Cell-Derived Human Cytomegalovirus Strains Display Distinct Neutralizing Antibody Responses and Varying Levels of gH/gL Complexes
by: Chiara Fornara, et al.
Published: (2023-02-01)

CRM197-conjugated peptides vaccine of HCMV pp65 and gH induce maturation of DC and effective viral-specific T cell responses
by: Shuyun Zhang, et al.
Published: (2023-12-01)

GDR (<ul>G</ul>enome <ul>D</ul>atabase for <ul>R</ul>osaceae): integrated web resources for Rosaceae genomics and genetics research
by: Ficklin Stephen, et al.
Published: (2004-09-01)

<i>In Vitro</i> Viral Evolution Identifies a Critical Residue in the Alphaherpesvirus Fusion Glycoprotein B Ectodomain That Controls gH/gL-Independent Entry
by: Melina Vallbracht, et al.
Published: (2021-06-01)

Detection of human cytomegalovirus (HCMV) DNA in HCMV IgM and IgG positive samples / Issabella Febrie Amot
by: Febrie Amot, Issabella
Published: (2015)

αvβ6- and αvβ8-integrins serve as interchangeable receptors for HSV gH/gL to promote endocytosis and activation of membrane fusion.
by: Tatiana Gianni, et al.
Published: (2013-01-01)

Human cytomegalovirus UL138 interaction with USP1 activates STAT1 in infection.
by: Kristen Zarrella, et al.
Published: (2023-06-01)

Sequencing of the Viral UL111a Gene Directly from Clinical Specimens Reveals Variants of HCMV-Encoded IL-10 That Are Associated with Altered Immune Responses to HCMV
by: Shelley Waters, et al.
Published: (2022-04-01)

Emergence of Letermovir-resistant HCMV UL56 mutant during rescue treatment in a liver transplant recipient with ganciclovir-resistant infection HCMV: a case report
by: Stefania Paolucci, et al.
Published: (2021-09-01)

The HCMV membrane glycoprotein US10 selectively targets HLA-G for degradation
by: Park, Boyoun, et al.
Published: (2014)

Indeterminate/moderate IgG avidity during HCMV infection: comparison of methods
by: Massimo De Paschale, et al.
Published: (2010-03-01)

A Comparative Quantitative Proteomic Analysis of HCMV-Infected Cells Highlights pUL138 as a Multifunctional Protein
by: Yang Li, et al.
Published: (2020-05-01)