Complexity of progranulin mechanisms of action in mesothelioma

Complexity of progranulin mechanisms of action in mesothelioma

Abstract Background Mesothelioma is an aggressive disease with limited therapeutic options. The growth factor progranulin plays a critical role in several cancer models, where it regulates tumor initiation and progression. Recent data from our laboratories have demonstrated that progranulin and its...

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Bibliographic Details
Main Authors: Elisa Ventura, Christopher Xie, Simone Buraschi, Antonino Belfiore, Renato V. Iozzo, Antonio Giordano, Andrea Morrione
Format: Article
Language:English
Published: BMC 2022-12-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Mesothelioma
Progranulin
EphA2
EGFR
RYK
FAK
Online Access:https://doi.org/10.1186/s13046-022-02546-4

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