Single-cell RNA-seq reveals dynamic change in tumor microenvironment during pancreatic ductal adenocarcinoma malignant progression

Single-cell RNA-seq reveals dynamic change in tumor microenvironment during pancreatic ductal adenocarcinoma malignant progression

Background: Pancreatic ductal adenocarcinoma (PDAC) is most aggressive among all gastrointestinal tumors. The complex intra-tumor heterogeneity and special tumor microenvironment in PDAC bring great challenges for developing effective treatment strategies. We aimed to delineate dynamic changes of tu...

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Bibliographic Details
Main Authors:	Kai Chen, Qi Wang, Mingzhe Li, Huahu Guo, Weikang Liu, Feng Wang, Xiaodong Tian, Yinmo Yang
Format:	Article
Language:	English
Published:	Elsevier 2021-04-01
Series:	EBioMedicine
Subjects:	Pancreatic cancer scRNA-seq Tumor microenvironment Cancer associated fibroblasts Intra-tumor heterogeneity
Online Access:	http://www.sciencedirect.com/science/article/pii/S2352396421001080

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