Sensitivity and specificity of frozen section diagnosis in orbital and adnexal malignancies
Purpose: To analyze the diagnostic accuracy of frozen section in orbital and adnexal malignancies. Methods: A total of 55 cases between January 2006 and December 2011 for which intraoperative frozen section was performed for various orbital and adnexal lesions were included in the study. The frozen...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2019-01-01
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| Series: | Indian Journal of Ophthalmology |
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| Online Access: | http://www.ijo.in/article.asp?issn=0301-4738;year=2019;volume=67;issue=12;spage=1988;epage=1992;aulast=Alam |
| _version_ | 1819160712353677312 |
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| author | Md Shahid Alam Andrea Tongbram Subramanian Krishnakumar Jyotirmay Biswas Bipasha Mukherjee |
| author_facet | Md Shahid Alam Andrea Tongbram Subramanian Krishnakumar Jyotirmay Biswas Bipasha Mukherjee |
| author_sort | Md Shahid Alam |
| collection | DOAJ |
| description | Purpose: To analyze the diagnostic accuracy of frozen section in orbital and adnexal malignancies. Methods: A total of 55 cases between January 2006 and December 2011 for which intraoperative frozen section was performed for various orbital and adnexal lesions were included in the study. The frozen section diagnosis was compared with the permanent section diagnosis. Margin clearance was also compared between the two. Data were analysed using SPSS version 14. Odds ratio and cross-tabulation was used to perform the analysis. Results: The mean age at presentation was 51.46 ± 20 years. Eyelid was the most common site of involvement. Out of 55 cases, diagnosis was deferred in four cases (7.27%) on frozen section. Among 51 cases, 44 (86%) cases were concordant, whereas 7 (13%) cases were discordant. The sensitivity and specificity of frozen section compared to permanent section for diagnosis of malignancy was found to be 87.2% and 87.5%, respectively. The sensitivity and specificity of frozen section for diagnoses of basal cell carcinoma was found to be 100%, while it was 83.3% and 100% respectively for sebaceous gland carcinoma and 87.5% and 94.9% respectively for squamous cell carcinoma. Conclusion: Frozen section had high sensitivity and specificity when compared with permanent section for all three parameters studied. It is an important intraoperative tool that is increasingly being used in histopathological examination of ophthalmic lesions. However, it should not be used as a substitute for the permanent section and critical decisions based on it are best avoided. |
| first_indexed | 2024-12-22T17:00:48Z |
| format | Article |
| id | doaj.art-e096095699354ddf8428de522d08dded |
| institution | Directory Open Access Journal |
| issn | 0301-4738 1998-3689 |
| language | English |
| last_indexed | 2024-12-22T17:00:48Z |
| publishDate | 2019-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Ophthalmology |
| spelling | doaj.art-e096095699354ddf8428de522d08dded2022-12-21T18:19:20ZengWolters Kluwer Medknow PublicationsIndian Journal of Ophthalmology0301-47381998-36892019-01-0167121988199210.4103/ijo.IJO_2096_18Sensitivity and specificity of frozen section diagnosis in orbital and adnexal malignanciesMd Shahid AlamAndrea TongbramSubramanian KrishnakumarJyotirmay BiswasBipasha MukherjeePurpose: To analyze the diagnostic accuracy of frozen section in orbital and adnexal malignancies. Methods: A total of 55 cases between January 2006 and December 2011 for which intraoperative frozen section was performed for various orbital and adnexal lesions were included in the study. The frozen section diagnosis was compared with the permanent section diagnosis. Margin clearance was also compared between the two. Data were analysed using SPSS version 14. Odds ratio and cross-tabulation was used to perform the analysis. Results: The mean age at presentation was 51.46 ± 20 years. Eyelid was the most common site of involvement. Out of 55 cases, diagnosis was deferred in four cases (7.27%) on frozen section. Among 51 cases, 44 (86%) cases were concordant, whereas 7 (13%) cases were discordant. The sensitivity and specificity of frozen section compared to permanent section for diagnosis of malignancy was found to be 87.2% and 87.5%, respectively. The sensitivity and specificity of frozen section for diagnoses of basal cell carcinoma was found to be 100%, while it was 83.3% and 100% respectively for sebaceous gland carcinoma and 87.5% and 94.9% respectively for squamous cell carcinoma. Conclusion: Frozen section had high sensitivity and specificity when compared with permanent section for all three parameters studied. It is an important intraoperative tool that is increasingly being used in histopathological examination of ophthalmic lesions. However, it should not be used as a substitute for the permanent section and critical decisions based on it are best avoided.http://www.ijo.in/article.asp?issn=0301-4738;year=2019;volume=67;issue=12;spage=1988;epage=1992;aulast=Alamadnexafrozen sectionorbitpermanent section |
| spellingShingle | Md Shahid Alam Andrea Tongbram Subramanian Krishnakumar Jyotirmay Biswas Bipasha Mukherjee Sensitivity and specificity of frozen section diagnosis in orbital and adnexal malignancies Indian Journal of Ophthalmology adnexa frozen section orbit permanent section |
| title | Sensitivity and specificity of frozen section diagnosis in orbital and adnexal malignancies |
| title_full | Sensitivity and specificity of frozen section diagnosis in orbital and adnexal malignancies |
| title_fullStr | Sensitivity and specificity of frozen section diagnosis in orbital and adnexal malignancies |
| title_full_unstemmed | Sensitivity and specificity of frozen section diagnosis in orbital and adnexal malignancies |
| title_short | Sensitivity and specificity of frozen section diagnosis in orbital and adnexal malignancies |
| title_sort | sensitivity and specificity of frozen section diagnosis in orbital and adnexal malignancies |
| topic | adnexa frozen section orbit permanent section |
| url | http://www.ijo.in/article.asp?issn=0301-4738;year=2019;volume=67;issue=12;spage=1988;epage=1992;aulast=Alam |
| work_keys_str_mv | AT mdshahidalam sensitivityandspecificityoffrozensectiondiagnosisinorbitalandadnexalmalignancies AT andreatongbram sensitivityandspecificityoffrozensectiondiagnosisinorbitalandadnexalmalignancies AT subramaniankrishnakumar sensitivityandspecificityoffrozensectiondiagnosisinorbitalandadnexalmalignancies AT jyotirmaybiswas sensitivityandspecificityoffrozensectiondiagnosisinorbitalandadnexalmalignancies AT bipashamukherjee sensitivityandspecificityoffrozensectiondiagnosisinorbitalandadnexalmalignancies |