Geometrically repatterned immunological synapses uncover formation mechanisms.
The interaction of T cells and antigen-presenting cells is central to adaptive immunity and involves the formation of immunological synapses in many cases. The surface molecules of the cells form a characteristic spatial pattern whose formation mechanisms and function are largely unknown. We perform...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2006-11-01
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| Series: | PLoS Computational Biology |
| Online Access: | http://europepmc.org/articles/PMC1635538?pdf=render |
| _version_ | 1811194124784631808 |
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| author | Marc Thilo Figge Michael Meyer-Hermann |
| author_facet | Marc Thilo Figge Michael Meyer-Hermann |
| author_sort | Marc Thilo Figge |
| collection | DOAJ |
| description | The interaction of T cells and antigen-presenting cells is central to adaptive immunity and involves the formation of immunological synapses in many cases. The surface molecules of the cells form a characteristic spatial pattern whose formation mechanisms and function are largely unknown. We perform computer simulations of recent experiments on geometrically repatterned immunological synapses and explain the emerging structure as well as the formation dynamics. Only the combination of in vitro experiments and computer simulations has the potential to pinpoint the kind of interactions involved. The presented simulations make clear predictions for the structure of the immunological synapse and elucidate the role of a self-organizing attraction between complexes of T cell receptor and peptide-MHC molecule, versus a centrally directed motion of these complexes. |
| first_indexed | 2024-04-12T00:20:42Z |
| format | Article |
| id | doaj.art-e09694be59f040ccb3687ef58e08f867 |
| institution | Directory Open Access Journal |
| issn | 1553-734X 1553-7358 |
| language | English |
| last_indexed | 2024-04-12T00:20:42Z |
| publishDate | 2006-11-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Computational Biology |
| spelling | doaj.art-e09694be59f040ccb3687ef58e08f8672022-12-22T03:55:44ZengPublic Library of Science (PLoS)PLoS Computational Biology1553-734X1553-73582006-11-01211e17110.1371/journal.pcbi.0020171Geometrically repatterned immunological synapses uncover formation mechanisms.Marc Thilo FiggeMichael Meyer-HermannThe interaction of T cells and antigen-presenting cells is central to adaptive immunity and involves the formation of immunological synapses in many cases. The surface molecules of the cells form a characteristic spatial pattern whose formation mechanisms and function are largely unknown. We perform computer simulations of recent experiments on geometrically repatterned immunological synapses and explain the emerging structure as well as the formation dynamics. Only the combination of in vitro experiments and computer simulations has the potential to pinpoint the kind of interactions involved. The presented simulations make clear predictions for the structure of the immunological synapse and elucidate the role of a self-organizing attraction between complexes of T cell receptor and peptide-MHC molecule, versus a centrally directed motion of these complexes.http://europepmc.org/articles/PMC1635538?pdf=render |
| spellingShingle | Marc Thilo Figge Michael Meyer-Hermann Geometrically repatterned immunological synapses uncover formation mechanisms. PLoS Computational Biology |
| title | Geometrically repatterned immunological synapses uncover formation mechanisms. |
| title_full | Geometrically repatterned immunological synapses uncover formation mechanisms. |
| title_fullStr | Geometrically repatterned immunological synapses uncover formation mechanisms. |
| title_full_unstemmed | Geometrically repatterned immunological synapses uncover formation mechanisms. |
| title_short | Geometrically repatterned immunological synapses uncover formation mechanisms. |
| title_sort | geometrically repatterned immunological synapses uncover formation mechanisms |
| url | http://europepmc.org/articles/PMC1635538?pdf=render |
| work_keys_str_mv | AT marcthilofigge geometricallyrepatternedimmunologicalsynapsesuncoverformationmechanisms AT michaelmeyerhermann geometricallyrepatternedimmunologicalsynapsesuncoverformationmechanisms |