Cellular and Molecular Signaling as Targets for Cancer Vaccine Therapeutics
Plenty of evidence has recently shown that various inflammatory activities at the local tissue, organ, or even the whole body (systemic) level are strongly linked to many life-threatening chronic diseases, most notably various cancers. However, only very limited information is available for making g...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-05-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/11/9/1590 |
| _version_ | 1797505288260026368 |
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| author | Wen-Chi Wei Lie-Fen Shyur Ning-Sun Yang |
| author_facet | Wen-Chi Wei Lie-Fen Shyur Ning-Sun Yang |
| author_sort | Wen-Chi Wei |
| collection | DOAJ |
| description | Plenty of evidence has recently shown that various inflammatory activities at the local tissue, organ, or even the whole body (systemic) level are strongly linked to many life-threatening chronic diseases, most notably various cancers. However, only very limited information is available for making good use of our supporting immune-modulatory therapeutics for the treatment of cancers. This may result from a lack of studies on specific remedies for efficacious control or modulatory suppression of inflammation-related cancerous diseases. Our group and laboratories were fortunate to have initiated and consistently pursued an integrated team-work program project, aimed at investigating selected medicinal herbs and the derived, purified phytochemical compounds. We focused on the study of key and specific immune-signaling mechanisms at the cellular and molecular levels. We were fortunate to obtain a series of fruitful research results. We believe that our key findings reported herein may be helpful for proposing future thematic and integrated research projects that aim to develop future phytochemical drugs against cancers. The mechanisms of the cellular and molecular systems involved in inflammation are becoming increasingly recognized as keystones for the development of future therapeutic approaches for many chronic and cancerous diseases. Recently, the immune checkpoint inhibitors such as antibodies against PD-1 and/or PD-L1 have been shown to be too expensive for general clinical use, and their effects far from optimal, often showing little or no effect or only short-term efficacy. These results point to the need for developing future immune-regulatory or modulatory therapeutics. |
| first_indexed | 2024-03-10T04:16:28Z |
| format | Article |
| id | doaj.art-e0971d20542e4578a3a71a38e50da290 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-10T04:16:28Z |
| publishDate | 2022-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-e0971d20542e4578a3a71a38e50da2902023-11-23T08:01:29ZengMDPI AGCells2073-44092022-05-01119159010.3390/cells11091590Cellular and Molecular Signaling as Targets for Cancer Vaccine TherapeuticsWen-Chi Wei0Lie-Fen Shyur1Ning-Sun Yang2National Research Institute of Chinese Medicine, Ministry of Health and Welfare, Taipei 112, TaiwanAgricultural Biotechnology Research Center, Academia Sinica, Taipei 115, TaiwanAgricultural Biotechnology Research Center, Academia Sinica, Taipei 115, TaiwanPlenty of evidence has recently shown that various inflammatory activities at the local tissue, organ, or even the whole body (systemic) level are strongly linked to many life-threatening chronic diseases, most notably various cancers. However, only very limited information is available for making good use of our supporting immune-modulatory therapeutics for the treatment of cancers. This may result from a lack of studies on specific remedies for efficacious control or modulatory suppression of inflammation-related cancerous diseases. Our group and laboratories were fortunate to have initiated and consistently pursued an integrated team-work program project, aimed at investigating selected medicinal herbs and the derived, purified phytochemical compounds. We focused on the study of key and specific immune-signaling mechanisms at the cellular and molecular levels. We were fortunate to obtain a series of fruitful research results. We believe that our key findings reported herein may be helpful for proposing future thematic and integrated research projects that aim to develop future phytochemical drugs against cancers. The mechanisms of the cellular and molecular systems involved in inflammation are becoming increasingly recognized as keystones for the development of future therapeutic approaches for many chronic and cancerous diseases. Recently, the immune checkpoint inhibitors such as antibodies against PD-1 and/or PD-L1 have been shown to be too expensive for general clinical use, and their effects far from optimal, often showing little or no effect or only short-term efficacy. These results point to the need for developing future immune-regulatory or modulatory therapeutics.https://www.mdpi.com/2073-4409/11/9/1590cancer immunotherapyDC-based cancer vaccineimmunogenic cell death (ICD)tumor microenvironmentphytochemicals |
| spellingShingle | Wen-Chi Wei Lie-Fen Shyur Ning-Sun Yang Cellular and Molecular Signaling as Targets for Cancer Vaccine Therapeutics Cells cancer immunotherapy DC-based cancer vaccine immunogenic cell death (ICD) tumor microenvironment phytochemicals |
| title | Cellular and Molecular Signaling as Targets for Cancer Vaccine Therapeutics |
| title_full | Cellular and Molecular Signaling as Targets for Cancer Vaccine Therapeutics |
| title_fullStr | Cellular and Molecular Signaling as Targets for Cancer Vaccine Therapeutics |
| title_full_unstemmed | Cellular and Molecular Signaling as Targets for Cancer Vaccine Therapeutics |
| title_short | Cellular and Molecular Signaling as Targets for Cancer Vaccine Therapeutics |
| title_sort | cellular and molecular signaling as targets for cancer vaccine therapeutics |
| topic | cancer immunotherapy DC-based cancer vaccine immunogenic cell death (ICD) tumor microenvironment phytochemicals |
| url | https://www.mdpi.com/2073-4409/11/9/1590 |
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