A lipidomics study reveals hepatic lipid signatures associating with deficiency of the LDL receptor in a rat model

A lipidomics study reveals hepatic lipid signatures associating with deficiency of the LDL receptor in a rat model

The low-density lipoprotein receptor (LDLR) plays a critical role in the liver for the clearance of plasma low-density lipoprotein (LDL). Its deficiency causes hypercholesterolemia in many models. To facilitate the usage of rats as animal models for the discovery of cholesterol-lowering drugs, we to...

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Bibliographic Details
Main Authors: Hong Yu Wang, Chao Quan, Chunxiu Hu, Bingxian Xie, Yinan Du, Liang Chen, Wei Yang, Liu Yang, Qiaoli Chen, Bin Shen, Bian Hu, Zhihong Zheng, Haibo Zhu, Xingxu Huang, Guowang Xu, Shuai Chen
Format: Article
Language:English
Published: The Company of Biologists 2016-07-01
Series:Biology Open
Subjects:
Low-density lipoprotein receptor (LDLR)
Cholesterol
Lipid metabolism
Rat
Knockout
Online Access:http://bio.biologists.org/content/5/7/979

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