Comparison of in Vitro Activity of Doripenem versus Old Carbapenems against Pseudomonas Aeruginosa Clinical Isolates from both CF and Burn Patients
Purpose: The antimicrobial activity of doripenem in comparison of imipenem, meropenem and ertapenem among Pseudomonas aeruginosa isolated from burn and Cystic Fibrosis (CF) patients were determined. Methods: Metallo-β-lactamase (MBL) genes in imipenem non susceptible P. aeruginosa isolates were dete...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Tabriz University of Medical Sciences
2013-02-01
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| Series: | Advanced Pharmaceutical Bulletin |
| Subjects: | |
| Online Access: | http://journals.tbzmed.ac.ir/PDF/APB/Manuscript/APB-3-121.pdf |
| _version_ | 1818118998575808512 |
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| author | Reza Bigverdi Mona Ghazi Mostafa Davodi Tahereh Pirzadeh Morteza Ghojazadeh Mohammad Hossein Soroush Mohammad Reza Nahaei Mohammad Ahangarzadeh Rezaee Zoya Hojabri Omid Pajand Mohammad Aghazadeh |
| author_facet | Reza Bigverdi Mona Ghazi Mostafa Davodi Tahereh Pirzadeh Morteza Ghojazadeh Mohammad Hossein Soroush Mohammad Reza Nahaei Mohammad Ahangarzadeh Rezaee Zoya Hojabri Omid Pajand Mohammad Aghazadeh |
| author_sort | Reza Bigverdi |
| collection | DOAJ |
| description | Purpose: The antimicrobial activity of doripenem in comparison of imipenem, meropenem and ertapenem among Pseudomonas aeruginosa isolated from burn and Cystic Fibrosis (CF) patients were determined. Methods: Metallo-β-lactamase (MBL) genes in imipenem non susceptible P. aeruginosa isolates were detected using PCR method. The in vitro susceptibilities of doripenem, imipenem, meropenem and ertapenem were determined by Etests. MIC50 and MIC90 for corresponding antibiotics were determined individually in burn and CF isolates. Results: Among isolates which were resistant to imipenem, 16 isolates were positive for the bla IMP gene. All isolates had no bla VIM gene. All MBL producing isolates were excluded. MIC50/MIC90 of doripenem in CF and burn isolates were 0.75/>32 and >32/>32 mg/L respectively. The corresponding values for imipenem in CF and burn isolates were 2/>32 and >32/>32 mg/L, respectively. Conclusion: The susceptibility rate of doripenem is higher than that of imipenem and meropenem among P.aeruginosa isolated from CF patients, whereas, there is no difference between the efficiency of doripenem and old carbapenems in non MBL producing P.aeruginosa isolates in burn patients. |
| first_indexed | 2024-12-11T05:03:13Z |
| format | Article |
| id | doaj.art-e0982b47fc1147a78bd36ffff3772495 |
| institution | Directory Open Access Journal |
| issn | 2228-5881 2251-7308 |
| language | English |
| last_indexed | 2024-12-11T05:03:13Z |
| publishDate | 2013-02-01 |
| publisher | Tabriz University of Medical Sciences |
| record_format | Article |
| series | Advanced Pharmaceutical Bulletin |
| spelling | doaj.art-e0982b47fc1147a78bd36ffff37724952022-12-22T01:20:06ZengTabriz University of Medical SciencesAdvanced Pharmaceutical Bulletin2228-58812251-73082013-02-013112112510.5681/apb.2013.020Comparison of in Vitro Activity of Doripenem versus Old Carbapenems against Pseudomonas Aeruginosa Clinical Isolates from both CF and Burn PatientsReza BigverdiMona GhaziMostafa DavodiTahereh PirzadehMorteza GhojazadehMohammad Hossein SoroushMohammad Reza NahaeiMohammad Ahangarzadeh RezaeeZoya HojabriOmid PajandMohammad AghazadehPurpose: The antimicrobial activity of doripenem in comparison of imipenem, meropenem and ertapenem among Pseudomonas aeruginosa isolated from burn and Cystic Fibrosis (CF) patients were determined. Methods: Metallo-β-lactamase (MBL) genes in imipenem non susceptible P. aeruginosa isolates were detected using PCR method. The in vitro susceptibilities of doripenem, imipenem, meropenem and ertapenem were determined by Etests. MIC50 and MIC90 for corresponding antibiotics were determined individually in burn and CF isolates. Results: Among isolates which were resistant to imipenem, 16 isolates were positive for the bla IMP gene. All isolates had no bla VIM gene. All MBL producing isolates were excluded. MIC50/MIC90 of doripenem in CF and burn isolates were 0.75/>32 and >32/>32 mg/L respectively. The corresponding values for imipenem in CF and burn isolates were 2/>32 and >32/>32 mg/L, respectively. Conclusion: The susceptibility rate of doripenem is higher than that of imipenem and meropenem among P.aeruginosa isolated from CF patients, whereas, there is no difference between the efficiency of doripenem and old carbapenems in non MBL producing P.aeruginosa isolates in burn patients.http://journals.tbzmed.ac.ir/PDF/APB/Manuscript/APB-3-121.pdfPseudomonas aeruginosaDoripenemImipenemBurnCystic fibrosisIran |
| spellingShingle | Reza Bigverdi Mona Ghazi Mostafa Davodi Tahereh Pirzadeh Morteza Ghojazadeh Mohammad Hossein Soroush Mohammad Reza Nahaei Mohammad Ahangarzadeh Rezaee Zoya Hojabri Omid Pajand Mohammad Aghazadeh Comparison of in Vitro Activity of Doripenem versus Old Carbapenems against Pseudomonas Aeruginosa Clinical Isolates from both CF and Burn Patients Advanced Pharmaceutical Bulletin Pseudomonas aeruginosa Doripenem Imipenem Burn Cystic fibrosis Iran |
| title | Comparison of in Vitro Activity of Doripenem versus Old Carbapenems against Pseudomonas Aeruginosa Clinical Isolates from both CF and Burn Patients |
| title_full | Comparison of in Vitro Activity of Doripenem versus Old Carbapenems against Pseudomonas Aeruginosa Clinical Isolates from both CF and Burn Patients |
| title_fullStr | Comparison of in Vitro Activity of Doripenem versus Old Carbapenems against Pseudomonas Aeruginosa Clinical Isolates from both CF and Burn Patients |
| title_full_unstemmed | Comparison of in Vitro Activity of Doripenem versus Old Carbapenems against Pseudomonas Aeruginosa Clinical Isolates from both CF and Burn Patients |
| title_short | Comparison of in Vitro Activity of Doripenem versus Old Carbapenems against Pseudomonas Aeruginosa Clinical Isolates from both CF and Burn Patients |
| title_sort | comparison of in vitro activity of doripenem versus old carbapenems against pseudomonas aeruginosa clinical isolates from both cf and burn patients |
| topic | Pseudomonas aeruginosa Doripenem Imipenem Burn Cystic fibrosis Iran |
| url | http://journals.tbzmed.ac.ir/PDF/APB/Manuscript/APB-3-121.pdf |
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