Fueling the Cycle: CDKs in Carbon and Energy Metabolism
Cyclin-dependent kinases (CDKs) are the central regulators of the eukaryotic cell cycle, and are conserved across eukaryotes. Their main and well-studied function lies in the regulation and the time-keeping of cell cycle entry and progression. Additionally, more and more non canonical functions of C...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2018-08-01
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| Series: | Frontiers in Cell and Developmental Biology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fcell.2018.00093/full |
| _version_ | 1818913092690509824 |
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| author | Maria Solaki Jennifer C. Ewald |
| author_facet | Maria Solaki Jennifer C. Ewald |
| author_sort | Maria Solaki |
| collection | DOAJ |
| description | Cyclin-dependent kinases (CDKs) are the central regulators of the eukaryotic cell cycle, and are conserved across eukaryotes. Their main and well-studied function lies in the regulation and the time-keeping of cell cycle entry and progression. Additionally, more and more non canonical functions of CDKs are being uncovered. One fairly recently discovered role of CDKs is the coordination of carbon and energy metabolism with proliferation. Evidence from different model organisms is accumulating that CDKs can directly and indirectly control fluxes through metabolism, for example by phosphorylating metabolic enzymes. In this mini-review, we summarize the emerging role of CDKs in regulating carbon and energy metabolism and discuss examples in different models from yeast to cancer cells. |
| first_indexed | 2024-12-19T23:25:00Z |
| format | Article |
| id | doaj.art-e098c4d203ac49a99f50f496545a760a |
| institution | Directory Open Access Journal |
| issn | 2296-634X |
| language | English |
| last_indexed | 2024-12-19T23:25:00Z |
| publishDate | 2018-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj.art-e098c4d203ac49a99f50f496545a760a2022-12-21T20:01:52ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2018-08-01610.3389/fcell.2018.00093401452Fueling the Cycle: CDKs in Carbon and Energy MetabolismMaria SolakiJennifer C. EwaldCyclin-dependent kinases (CDKs) are the central regulators of the eukaryotic cell cycle, and are conserved across eukaryotes. Their main and well-studied function lies in the regulation and the time-keeping of cell cycle entry and progression. Additionally, more and more non canonical functions of CDKs are being uncovered. One fairly recently discovered role of CDKs is the coordination of carbon and energy metabolism with proliferation. Evidence from different model organisms is accumulating that CDKs can directly and indirectly control fluxes through metabolism, for example by phosphorylating metabolic enzymes. In this mini-review, we summarize the emerging role of CDKs in regulating carbon and energy metabolism and discuss examples in different models from yeast to cancer cells.https://www.frontiersin.org/article/10.3389/fcell.2018.00093/fullcell division cycleproliferationcyclin-dependent kinasemetabolismenergy homeostasismetabolic fluxes |
| spellingShingle | Maria Solaki Jennifer C. Ewald Fueling the Cycle: CDKs in Carbon and Energy Metabolism Frontiers in Cell and Developmental Biology cell division cycle proliferation cyclin-dependent kinase metabolism energy homeostasis metabolic fluxes |
| title | Fueling the Cycle: CDKs in Carbon and Energy Metabolism |
| title_full | Fueling the Cycle: CDKs in Carbon and Energy Metabolism |
| title_fullStr | Fueling the Cycle: CDKs in Carbon and Energy Metabolism |
| title_full_unstemmed | Fueling the Cycle: CDKs in Carbon and Energy Metabolism |
| title_short | Fueling the Cycle: CDKs in Carbon and Energy Metabolism |
| title_sort | fueling the cycle cdks in carbon and energy metabolism |
| topic | cell division cycle proliferation cyclin-dependent kinase metabolism energy homeostasis metabolic fluxes |
| url | https://www.frontiersin.org/article/10.3389/fcell.2018.00093/full |
| work_keys_str_mv | AT mariasolaki fuelingthecyclecdksincarbonandenergymetabolism AT jennifercewald fuelingthecyclecdksincarbonandenergymetabolism |