Co-delivery of deferoxamine and hydroxysafflor yellow A to accelerate diabetic wound healing via enhanced angiogenesis
Nonhealing chronic wounds on foot induced by diabetes is a complicated pathologic process. They are mainly caused by impaired neovascularization, neuropathy, and excessive inflammation. A strategy, which can accelerate the vessel network formation as well as inhibit inflammatory response at the same...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2018-01-01
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| Series: | Drug Delivery |
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| Online Access: | http://dx.doi.org/10.1080/10717544.2018.1513608 |
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| author | Si-Qian Gao Chen Chang Jun-Jun Li Ying Li Xiao-Qian Niu Dan-Ping Zhang Long-Jian Li Jian-Qing Gao |
| author_facet | Si-Qian Gao Chen Chang Jun-Jun Li Ying Li Xiao-Qian Niu Dan-Ping Zhang Long-Jian Li Jian-Qing Gao |
| author_sort | Si-Qian Gao |
| collection | DOAJ |
| description | Nonhealing chronic wounds on foot induced by diabetes is a complicated pathologic process. They are mainly caused by impaired neovascularization, neuropathy, and excessive inflammation. A strategy, which can accelerate the vessel network formation as well as inhibit inflammatory response at the same time, makes it possible for effective diabetic ulcers treatment. Co-delivery of multiple drugs with complementary bioactivity offers a strategy to properly treat diabetic wound. We previously demonstrated that hydroxysafflor yellow A (HSYA) could accelerate diabetic wound healing through promoting angiogenesis and reducing inflammatory response. In order to further enhance blood vessel formation, a pro-angiogenic molecular called deferoxamine (DFO) was topically co-administrated with HSYA. The in vitro results showed that the combination of DFO and HSYA exerted synergistic effect on enhancing angiogenesis by upregulation of hypoxia inducible factor-1 alpha (HIF-1α) expression. The interpenetrating polymer networks hydrogels, characterized by good breathability and water absorption, were designed for co-loading of DFO and HSYA aiming to recruit angiogenesis relative cells and upgrade wound healing in vivo. Both DFO and HSYA in hydrogel have achieved sustained release. The in vivo studies indicated that HSYA/DFO hydrogel could accelerate diabetic wound healing. With a high expression of Hif-1α which is similar to that of normal tissue. The noninvasive US/PA imaging revealed that the wound could be recovered completely with abundant blood perfusion in dermis after given HSYA/DFO hydrogel for 28 days. In conclusion, combination of pro-angiogenic small molecule DFO and HSYA in hydrogel provides a promising strategy to productively promote diabetic wound healing as well as better the repair quality. |
| first_indexed | 2024-12-13T01:33:26Z |
| format | Article |
| id | doaj.art-e098dab4c21b4a6c989bcc9b9590ab86 |
| institution | Directory Open Access Journal |
| issn | 1071-7544 1521-0464 |
| language | English |
| last_indexed | 2024-12-13T01:33:26Z |
| publishDate | 2018-01-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Drug Delivery |
| spelling | doaj.art-e098dab4c21b4a6c989bcc9b9590ab862022-12-22T00:03:57ZengTaylor & Francis GroupDrug Delivery1071-75441521-04642018-01-012511779178910.1080/10717544.2018.15136081513608Co-delivery of deferoxamine and hydroxysafflor yellow A to accelerate diabetic wound healing via enhanced angiogenesisSi-Qian Gao0Chen Chang1Jun-Jun Li2Ying Li3Xiao-Qian Niu4Dan-Ping Zhang5Long-Jian Li6Jian-Qing Gao7Zhejiang UniversityZhejiang UniversityZhejiang UniversityZhejiang UniversityZhejiang UniversityZhejiang UniversityZhejiang Provincial Corps Hospital of Chinese People's Armed Police Forces, JiaxingZhejiang UniversityNonhealing chronic wounds on foot induced by diabetes is a complicated pathologic process. They are mainly caused by impaired neovascularization, neuropathy, and excessive inflammation. A strategy, which can accelerate the vessel network formation as well as inhibit inflammatory response at the same time, makes it possible for effective diabetic ulcers treatment. Co-delivery of multiple drugs with complementary bioactivity offers a strategy to properly treat diabetic wound. We previously demonstrated that hydroxysafflor yellow A (HSYA) could accelerate diabetic wound healing through promoting angiogenesis and reducing inflammatory response. In order to further enhance blood vessel formation, a pro-angiogenic molecular called deferoxamine (DFO) was topically co-administrated with HSYA. The in vitro results showed that the combination of DFO and HSYA exerted synergistic effect on enhancing angiogenesis by upregulation of hypoxia inducible factor-1 alpha (HIF-1α) expression. The interpenetrating polymer networks hydrogels, characterized by good breathability and water absorption, were designed for co-loading of DFO and HSYA aiming to recruit angiogenesis relative cells and upgrade wound healing in vivo. Both DFO and HSYA in hydrogel have achieved sustained release. The in vivo studies indicated that HSYA/DFO hydrogel could accelerate diabetic wound healing. With a high expression of Hif-1α which is similar to that of normal tissue. The noninvasive US/PA imaging revealed that the wound could be recovered completely with abundant blood perfusion in dermis after given HSYA/DFO hydrogel for 28 days. In conclusion, combination of pro-angiogenic small molecule DFO and HSYA in hydrogel provides a promising strategy to productively promote diabetic wound healing as well as better the repair quality.http://dx.doi.org/10.1080/10717544.2018.1513608hydroxysafflor yellow adeferoxaminediabetic wound healingangiogenesishydrogel |
| spellingShingle | Si-Qian Gao Chen Chang Jun-Jun Li Ying Li Xiao-Qian Niu Dan-Ping Zhang Long-Jian Li Jian-Qing Gao Co-delivery of deferoxamine and hydroxysafflor yellow A to accelerate diabetic wound healing via enhanced angiogenesis Drug Delivery hydroxysafflor yellow a deferoxamine diabetic wound healing angiogenesis hydrogel |
| title | Co-delivery of deferoxamine and hydroxysafflor yellow A to accelerate diabetic wound healing via enhanced angiogenesis |
| title_full | Co-delivery of deferoxamine and hydroxysafflor yellow A to accelerate diabetic wound healing via enhanced angiogenesis |
| title_fullStr | Co-delivery of deferoxamine and hydroxysafflor yellow A to accelerate diabetic wound healing via enhanced angiogenesis |
| title_full_unstemmed | Co-delivery of deferoxamine and hydroxysafflor yellow A to accelerate diabetic wound healing via enhanced angiogenesis |
| title_short | Co-delivery of deferoxamine and hydroxysafflor yellow A to accelerate diabetic wound healing via enhanced angiogenesis |
| title_sort | co delivery of deferoxamine and hydroxysafflor yellow a to accelerate diabetic wound healing via enhanced angiogenesis |
| topic | hydroxysafflor yellow a deferoxamine diabetic wound healing angiogenesis hydrogel |
| url | http://dx.doi.org/10.1080/10717544.2018.1513608 |
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