Impact of Treatment with Antioxidants as an Adjuvant to Standard Therapy in Patients with Septic Shock: Analysis of the Correlation between Cytokine Storm and Oxidative Stress and Therapeutic Effects
Cellular homeostasis is lost or becomes dysfunctional during septic shock due to the activation of the inflammatory response and the deregulation of oxidative stress. Antioxidant therapy administered alongside standard treatment could restore this lost homeostasis. We included 131 patients with sept...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-11-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/23/16610 |
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| author | Israel Pérez-Torres Alfredo Aisa-Álvarez Sergio Casarez-Alvarado Gabriela Borrayo Ricardo Márquez-Velasco Verónica Guarner-Lans Linaloe Manzano-Pech Randall Cruz-Soto Omar Gonzalez-Marcos Giovanny Fuentevilla-Álvarez Ricardo Gamboa Huitizilihuitl Saucedo-Orozco Juvenal Franco-Granillo María Elena Soto |
| author_facet | Israel Pérez-Torres Alfredo Aisa-Álvarez Sergio Casarez-Alvarado Gabriela Borrayo Ricardo Márquez-Velasco Verónica Guarner-Lans Linaloe Manzano-Pech Randall Cruz-Soto Omar Gonzalez-Marcos Giovanny Fuentevilla-Álvarez Ricardo Gamboa Huitizilihuitl Saucedo-Orozco Juvenal Franco-Granillo María Elena Soto |
| author_sort | Israel Pérez-Torres |
| collection | DOAJ |
| description | Cellular homeostasis is lost or becomes dysfunctional during septic shock due to the activation of the inflammatory response and the deregulation of oxidative stress. Antioxidant therapy administered alongside standard treatment could restore this lost homeostasis. We included 131 patients with septic shock who were treated with standard treatment and vitamin C (Vit C), vitamin E (Vit E), N-acetylcysteine (NAC), or melatonin (MT), in a randomized trial. Organ damage quantified by Sequential Organ Failure Assessment (SOFA) score, and we determined levels of Interleukins (IL) IL1β, Tumor necrosis factor alpha (TNFα), IL-6, monocyte chemoattractant protein-1 (MCP-1), Transforming growth factor B (TGFβ), IL-4, IL-10, IL-12, and Interferon-γ (IFNγ). The SOFA score decreased in patients treated with Vit C, NAC, and MT. Patients treated with MT had statistically significantly reduced of IL-6, IL-8, MCP-1, and IL-10 levels. Lipid peroxidation, Nitrates and nitrites (NO<sub>3</sub><sup>−</sup> and NO<sub>2</sub><sup>−</sup>), glutathione reductase, and superoxide dismutase decreased after treatment with Vit C, Vit E, NAC, and MT. The levels of thiols recovered with the use of Vit E, and all patients treated with antioxidants maintained their selenium levels, in contrast with controls (<i>p</i> = 0.04). The findings regarding oxidative stress markers and cytokines after treatment with antioxidants allow us to consider to future the combined use of antioxidants in a randomized clinical trial with a larger sample to demonstrate the reproducibility of these beneficial effects. |
| first_indexed | 2024-03-09T01:51:18Z |
| format | Article |
| id | doaj.art-e09b584e3a13457087699ff53ddc54e0 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T01:51:18Z |
| publishDate | 2023-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-e09b584e3a13457087699ff53ddc54e02023-12-08T15:16:31ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-11-0124231661010.3390/ijms242316610Impact of Treatment with Antioxidants as an Adjuvant to Standard Therapy in Patients with Septic Shock: Analysis of the Correlation between Cytokine Storm and Oxidative Stress and Therapeutic EffectsIsrael Pérez-Torres0Alfredo Aisa-Álvarez1Sergio Casarez-Alvarado2Gabriela Borrayo3Ricardo Márquez-Velasco4Verónica Guarner-Lans5Linaloe Manzano-Pech6Randall Cruz-Soto7Omar Gonzalez-Marcos8Giovanny Fuentevilla-Álvarez9Ricardo Gamboa10Huitizilihuitl Saucedo-Orozco11Juvenal Franco-Granillo12María Elena Soto13Cardiovascular Biomedicine Department, Instituto Nacional de Cardiología Ignacio Chávez, Juan Badiano No. 1, Col. Sección XVI, Mexico City 14380, MexicoCritical Care Department, American British Cowdray (ABC) Medical Center, PAI ABC Sur 136 No. 116, Col. las Américas, Mexico City 01120, MexicoImmunology Department, Instituto Nacional de Cardiología Ignacio Chávez, Juan Badiano No. 1, Col. Sección XVI, Mexico City 14380, MexicoInstituto Mexicano del Seguro Social, Dirección de Prestaciones Médicas Coordinación de Innovación en Salud, Ciudad de México 06700, MexicoImmunology Department, Instituto Nacional de Cardiología Ignacio Chávez, Juan Badiano No. 1, Col. Sección XVI, Mexico City 14380, MexicoPhysiology Department, Instituto Nacional de Cardiología Ignacio Chávez, Juan Badiano No. 1, Col. Sección XVI, Mexico City 14380, MexicoCardiovascular Biomedicine Department, Instituto Nacional de Cardiología Ignacio Chávez, Juan Badiano No. 1, Col. Sección XVI, Mexico City 14380, MexicoImmunology Department, Instituto Nacional de Cardiología Ignacio Chávez, Juan Badiano No. 1, Col. Sección XVI, Mexico City 14380, MexicoCritical Care Department, American British Cowdray (ABC) Medical Center, PAI ABC Sur 136 No. 116, Col. las Américas, Mexico City 01120, MexicoPhysiology Department, Instituto Nacional de Cardiología Ignacio Chávez, Juan Badiano No. 1, Col. Sección XVI, Mexico City 14380, MexicoPhysiology Department, Instituto Nacional de Cardiología Ignacio Chávez, Juan Badiano No. 1, Col. Sección XVI, Mexico City 14380, MexicoCardioneumology Department, Specialty Hospital, National Medical Center “La Raza”, Mexico City 02990, MexicoCritical Care Department, American British Cowdray (ABC) Medical Center, PAI ABC Sur 136 No. 116, Col. las Américas, Mexico City 01120, MexicoImmunology Department, Instituto Nacional de Cardiología Ignacio Chávez, Juan Badiano No. 1, Col. Sección XVI, Mexico City 14380, MexicoCellular homeostasis is lost or becomes dysfunctional during septic shock due to the activation of the inflammatory response and the deregulation of oxidative stress. Antioxidant therapy administered alongside standard treatment could restore this lost homeostasis. We included 131 patients with septic shock who were treated with standard treatment and vitamin C (Vit C), vitamin E (Vit E), N-acetylcysteine (NAC), or melatonin (MT), in a randomized trial. Organ damage quantified by Sequential Organ Failure Assessment (SOFA) score, and we determined levels of Interleukins (IL) IL1β, Tumor necrosis factor alpha (TNFα), IL-6, monocyte chemoattractant protein-1 (MCP-1), Transforming growth factor B (TGFβ), IL-4, IL-10, IL-12, and Interferon-γ (IFNγ). The SOFA score decreased in patients treated with Vit C, NAC, and MT. Patients treated with MT had statistically significantly reduced of IL-6, IL-8, MCP-1, and IL-10 levels. Lipid peroxidation, Nitrates and nitrites (NO<sub>3</sub><sup>−</sup> and NO<sub>2</sub><sup>−</sup>), glutathione reductase, and superoxide dismutase decreased after treatment with Vit C, Vit E, NAC, and MT. The levels of thiols recovered with the use of Vit E, and all patients treated with antioxidants maintained their selenium levels, in contrast with controls (<i>p</i> = 0.04). The findings regarding oxidative stress markers and cytokines after treatment with antioxidants allow us to consider to future the combined use of antioxidants in a randomized clinical trial with a larger sample to demonstrate the reproducibility of these beneficial effects.https://www.mdpi.com/1422-0067/24/23/16610antioxidantsseptic shockmelatonincytokines |
| spellingShingle | Israel Pérez-Torres Alfredo Aisa-Álvarez Sergio Casarez-Alvarado Gabriela Borrayo Ricardo Márquez-Velasco Verónica Guarner-Lans Linaloe Manzano-Pech Randall Cruz-Soto Omar Gonzalez-Marcos Giovanny Fuentevilla-Álvarez Ricardo Gamboa Huitizilihuitl Saucedo-Orozco Juvenal Franco-Granillo María Elena Soto Impact of Treatment with Antioxidants as an Adjuvant to Standard Therapy in Patients with Septic Shock: Analysis of the Correlation between Cytokine Storm and Oxidative Stress and Therapeutic Effects International Journal of Molecular Sciences antioxidants septic shock melatonin cytokines |
| title | Impact of Treatment with Antioxidants as an Adjuvant to Standard Therapy in Patients with Septic Shock: Analysis of the Correlation between Cytokine Storm and Oxidative Stress and Therapeutic Effects |
| title_full | Impact of Treatment with Antioxidants as an Adjuvant to Standard Therapy in Patients with Septic Shock: Analysis of the Correlation between Cytokine Storm and Oxidative Stress and Therapeutic Effects |
| title_fullStr | Impact of Treatment with Antioxidants as an Adjuvant to Standard Therapy in Patients with Septic Shock: Analysis of the Correlation between Cytokine Storm and Oxidative Stress and Therapeutic Effects |
| title_full_unstemmed | Impact of Treatment with Antioxidants as an Adjuvant to Standard Therapy in Patients with Septic Shock: Analysis of the Correlation between Cytokine Storm and Oxidative Stress and Therapeutic Effects |
| title_short | Impact of Treatment with Antioxidants as an Adjuvant to Standard Therapy in Patients with Septic Shock: Analysis of the Correlation between Cytokine Storm and Oxidative Stress and Therapeutic Effects |
| title_sort | impact of treatment with antioxidants as an adjuvant to standard therapy in patients with septic shock analysis of the correlation between cytokine storm and oxidative stress and therapeutic effects |
| topic | antioxidants septic shock melatonin cytokines |
| url | https://www.mdpi.com/1422-0067/24/23/16610 |
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