Tropheryma whipplei in Patients with Pneumonia
Tropheryma whipplei is the etiologic pathogenic agent of Whipple disease (WD), characterized by various clinical signs, such as diarrhea, weight loss, lymphadenopathy, and polyarthritis. PCR-based methods for diagnosis of WD have been developed. T. whipplei has been identified in saliva and stool sa...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Centers for Disease Control and Prevention
2010-02-01
|
| Series: | Emerging Infectious Diseases |
| Subjects: | |
| Online Access: | https://wwwnc.cdc.gov/eid/article/16/2/09-0610_article |
| _version_ | 1818033243128070144 |
|---|---|
| author | Sabri Bousbia Laurent Papazian Jean-Pierre Auffray Florence Fenollar Claude Martin Wenjun Li Laurent Chiche Bernard La Scola Didier Raoult |
| author_facet | Sabri Bousbia Laurent Papazian Jean-Pierre Auffray Florence Fenollar Claude Martin Wenjun Li Laurent Chiche Bernard La Scola Didier Raoult |
| author_sort | Sabri Bousbia |
| collection | DOAJ |
| description | Tropheryma whipplei is the etiologic pathogenic agent of Whipple disease (WD), characterized by various clinical signs, such as diarrhea, weight loss, lymphadenopathy, and polyarthritis. PCR-based methods for diagnosis of WD have been developed. T. whipplei has been identified in saliva and stool samples from patients with WD and from healthy persons. T. whipplei DNA has also been found in bronchoalveolar lavage (BAL) samples of a child with pneumonia. We detected DNA of T. whipplei in 6 (3%) of 210 BAL samples collected in intensive care units by using 16S rDNA and specific quantitative PCR. We identified 4 novel genotypes of T. whipplei. In 1 case, T. whipplei was the only bacterium; in 4 others, it was associated with buccal flora. We suggest that T. whipplei should be investigated as an etiologic agent of pneumonia. |
| first_indexed | 2024-12-10T06:20:10Z |
| format | Article |
| id | doaj.art-e09b73a56be14f1eb1d9df429dd450cc |
| institution | Directory Open Access Journal |
| issn | 1080-6040 1080-6059 |
| language | English |
| last_indexed | 2024-12-10T06:20:10Z |
| publishDate | 2010-02-01 |
| publisher | Centers for Disease Control and Prevention |
| record_format | Article |
| series | Emerging Infectious Diseases |
| spelling | doaj.art-e09b73a56be14f1eb1d9df429dd450cc2022-12-22T01:59:22ZengCenters for Disease Control and PreventionEmerging Infectious Diseases1080-60401080-60592010-02-0116225826310.3201/eid1602.090610Tropheryma whipplei in Patients with PneumoniaSabri BousbiaLaurent PapazianJean-Pierre AuffrayFlorence FenollarClaude MartinWenjun LiLaurent ChicheBernard La ScolaDidier RaoultTropheryma whipplei is the etiologic pathogenic agent of Whipple disease (WD), characterized by various clinical signs, such as diarrhea, weight loss, lymphadenopathy, and polyarthritis. PCR-based methods for diagnosis of WD have been developed. T. whipplei has been identified in saliva and stool samples from patients with WD and from healthy persons. T. whipplei DNA has also been found in bronchoalveolar lavage (BAL) samples of a child with pneumonia. We detected DNA of T. whipplei in 6 (3%) of 210 BAL samples collected in intensive care units by using 16S rDNA and specific quantitative PCR. We identified 4 novel genotypes of T. whipplei. In 1 case, T. whipplei was the only bacterium; in 4 others, it was associated with buccal flora. We suggest that T. whipplei should be investigated as an etiologic agent of pneumonia.https://wwwnc.cdc.gov/eid/article/16/2/09-0610_articleTropheryma whippleiWhipple diseaseWhipple disease diagnosisventilator-associated pneumoniagenotypingbacteria |
| spellingShingle | Sabri Bousbia Laurent Papazian Jean-Pierre Auffray Florence Fenollar Claude Martin Wenjun Li Laurent Chiche Bernard La Scola Didier Raoult Tropheryma whipplei in Patients with Pneumonia Emerging Infectious Diseases Tropheryma whipplei Whipple disease Whipple disease diagnosis ventilator-associated pneumonia genotyping bacteria |
| title | Tropheryma whipplei in Patients with Pneumonia |
| title_full | Tropheryma whipplei in Patients with Pneumonia |
| title_fullStr | Tropheryma whipplei in Patients with Pneumonia |
| title_full_unstemmed | Tropheryma whipplei in Patients with Pneumonia |
| title_short | Tropheryma whipplei in Patients with Pneumonia |
| title_sort | tropheryma whipplei in patients with pneumonia |
| topic | Tropheryma whipplei Whipple disease Whipple disease diagnosis ventilator-associated pneumonia genotyping bacteria |
| url | https://wwwnc.cdc.gov/eid/article/16/2/09-0610_article |
| work_keys_str_mv | AT sabribousbia tropherymawhippleiinpatientswithpneumonia AT laurentpapazian tropherymawhippleiinpatientswithpneumonia AT jeanpierreauffray tropherymawhippleiinpatientswithpneumonia AT florencefenollar tropherymawhippleiinpatientswithpneumonia AT claudemartin tropherymawhippleiinpatientswithpneumonia AT wenjunli tropherymawhippleiinpatientswithpneumonia AT laurentchiche tropherymawhippleiinpatientswithpneumonia AT bernardlascola tropherymawhippleiinpatientswithpneumonia AT didierraoult tropherymawhippleiinpatientswithpneumonia |