Association of appendicular skeletal muscle mass with carotid intima-media thickness according to body mass index in Korean adults
OBJECTIVES The combined effects of obesity and appendicular skeletal muscle (ASM) on atherosclerosis, especially in middleaged populations, remain poorly understood. This cross-sectional study investigated the effects of ASM on carotid intima-media thickness (IMT) according to body mass index (BMI)...
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| Format: | Article |
| Language: | English |
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Korean Society of Epidemiology
2018-10-01
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| Series: | Epidemiology and Health |
| Subjects: | |
| Online Access: | http://www.e-epih.org/upload/pdf/epih-40-e2018049.pdf |
| _version_ | 1818934144347930624 |
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| author | Ji Eun Heo Hyeon Chang Kim Jee-Seon Shim Bo Mi Song Hye Yoon Bae Ho Jae Lee Il Suh |
| author_facet | Ji Eun Heo Hyeon Chang Kim Jee-Seon Shim Bo Mi Song Hye Yoon Bae Ho Jae Lee Il Suh |
| author_sort | Ji Eun Heo |
| collection | DOAJ |
| description | OBJECTIVES The combined effects of obesity and appendicular skeletal muscle (ASM) on atherosclerosis, especially in middleaged populations, remain poorly understood. This cross-sectional study investigated the effects of ASM on carotid intima-media thickness (IMT) according to body mass index (BMI) in middle-aged Korean adults. METHODS Herein, 595 men and 1,274 women aged 30-64 years completed questionnaires and underwent health examinations as part of the Cardiovascular and Metabolic Disease Etiology Research Center cohort. ASM was measured via bioelectrical impedance analysis and adjusted for weight (ASM/Wt). IMT was assessed using B-mode ultrasonography; highest quartile of IMT was defined as gender-specific top quartile of the IMT values. Higher BMIs was defined as a BMI over 25.0 kg/m2 . RESULTS Compared to the highest ASM/Wt quartile, the lowest ASM/Wt quartile was significantly associated with highest quartile of IMT in men with lower BMIs (adjusted odds ratio [aOR], 2.78; 95% confidence interval [CI], 1.09 to 7.13), but not in those with higher BMIs (aOR, 0.59; 95% CI, 0.24 to 1.91). In women, there was no significant association of low skeletal muscle mass with highest quartile of IMT, regardless of BMI. CONCLUSIONS Low appendicular skeletal muscle mass is associated with carotid arterial wall thickening in men with lower BMIs, but not in men with higher BMIs. Our findings suggest that the risk of atherosclerosis may be low in middle-aged Korean men with appropriate body weight and skeletal muscle mass maintenance. |
| first_indexed | 2024-12-20T04:59:36Z |
| format | Article |
| id | doaj.art-e09c42750a674f088637c16e6d6a3e4a |
| institution | Directory Open Access Journal |
| issn | 2092-7193 |
| language | English |
| last_indexed | 2024-12-20T04:59:36Z |
| publishDate | 2018-10-01 |
| publisher | Korean Society of Epidemiology |
| record_format | Article |
| series | Epidemiology and Health |
| spelling | doaj.art-e09c42750a674f088637c16e6d6a3e4a2022-12-21T19:52:37ZengKorean Society of EpidemiologyEpidemiology and Health2092-71932018-10-014010.4178/epih.e20180491002Association of appendicular skeletal muscle mass with carotid intima-media thickness according to body mass index in Korean adultsJi Eun Heo0Hyeon Chang Kim1Jee-Seon Shim2Bo Mi Song3Hye Yoon Bae4Ho Jae Lee5Il Suh6 Department of Public Health, Yonsei University Graduate School, Seoul, Korea Cardiovascular and Metabolic Disease Etiology Research Center, Yonsei University College of Medicine, Seoul, Korea Cardiovascular and Metabolic Disease Etiology Research Center, Yonsei University College of Medicine, Seoul, Korea Cardiovascular and Metabolic Disease Etiology Research Center, Yonsei University College of Medicine, Seoul, Korea Cardiovascular and Metabolic Disease Etiology Research Center, Yonsei University College of Medicine, Seoul, Korea Cardiovascular and Metabolic Disease Etiology Research Center, Yonsei University College of Medicine, Seoul, Korea Department of Preventive Medicine, Yonsei University College of Medicine, Seoul, KoreaOBJECTIVES The combined effects of obesity and appendicular skeletal muscle (ASM) on atherosclerosis, especially in middleaged populations, remain poorly understood. This cross-sectional study investigated the effects of ASM on carotid intima-media thickness (IMT) according to body mass index (BMI) in middle-aged Korean adults. METHODS Herein, 595 men and 1,274 women aged 30-64 years completed questionnaires and underwent health examinations as part of the Cardiovascular and Metabolic Disease Etiology Research Center cohort. ASM was measured via bioelectrical impedance analysis and adjusted for weight (ASM/Wt). IMT was assessed using B-mode ultrasonography; highest quartile of IMT was defined as gender-specific top quartile of the IMT values. Higher BMIs was defined as a BMI over 25.0 kg/m2 . RESULTS Compared to the highest ASM/Wt quartile, the lowest ASM/Wt quartile was significantly associated with highest quartile of IMT in men with lower BMIs (adjusted odds ratio [aOR], 2.78; 95% confidence interval [CI], 1.09 to 7.13), but not in those with higher BMIs (aOR, 0.59; 95% CI, 0.24 to 1.91). In women, there was no significant association of low skeletal muscle mass with highest quartile of IMT, regardless of BMI. CONCLUSIONS Low appendicular skeletal muscle mass is associated with carotid arterial wall thickening in men with lower BMIs, but not in men with higher BMIs. Our findings suggest that the risk of atherosclerosis may be low in middle-aged Korean men with appropriate body weight and skeletal muscle mass maintenance.http://www.e-epih.org/upload/pdf/epih-40-e2018049.pdfSarcopeniaMusclesSkeletalBody mass indexBody compositionAtherosclerosis |
| spellingShingle | Ji Eun Heo Hyeon Chang Kim Jee-Seon Shim Bo Mi Song Hye Yoon Bae Ho Jae Lee Il Suh Association of appendicular skeletal muscle mass with carotid intima-media thickness according to body mass index in Korean adults Epidemiology and Health Sarcopenia Muscles Skeletal Body mass index Body composition Atherosclerosis |
| title | Association of appendicular skeletal muscle mass with carotid intima-media thickness according to body mass index in Korean adults |
| title_full | Association of appendicular skeletal muscle mass with carotid intima-media thickness according to body mass index in Korean adults |
| title_fullStr | Association of appendicular skeletal muscle mass with carotid intima-media thickness according to body mass index in Korean adults |
| title_full_unstemmed | Association of appendicular skeletal muscle mass with carotid intima-media thickness according to body mass index in Korean adults |
| title_short | Association of appendicular skeletal muscle mass with carotid intima-media thickness according to body mass index in Korean adults |
| title_sort | association of appendicular skeletal muscle mass with carotid intima media thickness according to body mass index in korean adults |
| topic | Sarcopenia Muscles Skeletal Body mass index Body composition Atherosclerosis |
| url | http://www.e-epih.org/upload/pdf/epih-40-e2018049.pdf |
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