<i>PCSK3</i> Overexpression in Sjögren’s Syndrome Patients May Be Regulated by rs4932178 SNP in Its Promoter Region and Correlates with <i>IFN-γ</i> Gene Expression

<i>PCSK3</i> Overexpression in Sjögren’s Syndrome Patients May Be Regulated by rs4932178 SNP in Its Promoter Region and Correlates with <i>IFN-γ</i> Gene Expression

Background: The <i>PCSK3</i> gene encodes for the protease enzyme Furin, which promotes proteolytic maturation of important regulators of the immune response, and also enhances the secretion of interferon-γ (IFN). Several studies have suggested its possible involvement in the pathogenesi...

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Bibliographic Details
Main Authors: Andrea Latini, Giada De Benedittis, Serena Colafrancesco, Carlo Perricone, Giuseppe Novelli, Lucia Novelli, Roberta Priori, Cinzia Ciccacci, Paola Borgiani
Format: Article
Language:English
Published: MDPI AG 2023-04-01
Series:Genes
Subjects:
Sjögren’s syndrome
<i>PCSK3</i>
<i>IFN-γ</i>
Online Access:https://www.mdpi.com/2073-4425/14/5/981

Internet

https://www.mdpi.com/2073-4425/14/5/981

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