Nitrogen-Doped Graphene-Based Sensor for Electrochemical Detection of Piroxicam, a NSAID Drug for COVID-19 Patients
Nitrogen-doped graphene (NGr) was synthesized by the hydrothermal method using urea as a reducing and doping agent for graphene oxide (GO). The crystalline structure of GO was revealed by the XRD intense peak recorded at 2θ = 11.4°, indicating that the interlayer distance within the structure was la...
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MDPI AG
2022-01-01
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| Series: | Chemosensors |
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| Online Access: | https://www.mdpi.com/2227-9040/10/2/47 |
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| author | Codruţa Varodi Maria Coros Florina Pogăcean Alexandra Ciorîţă Alexandru Turza Stela Pruneanu |
| author_facet | Codruţa Varodi Maria Coros Florina Pogăcean Alexandra Ciorîţă Alexandru Turza Stela Pruneanu |
| author_sort | Codruţa Varodi |
| collection | DOAJ |
| description | Nitrogen-doped graphene (NGr) was synthesized by the hydrothermal method using urea as a reducing and doping agent for graphene oxide (GO). The crystalline structure of GO was revealed by the XRD intense peak recorded at 2θ = 11.4°, indicating that the interlayer distance within the structure was large (d = 0.77 nm), and the number of layers (n) was 9. Further, the transformation of GO in NGr also led to the decrease in the interlayer distance and number of layers (d = 0.387 nm; n = 3). As indicated by elemental analysis, the concentration of nitrogen in the NGr sample was 6 wt%. Next, the comparison between the performance of bare GC and the graphene-modified electrode (NGr/GC) towards piroxicam (PIR) detection was studied. Significant differences were observed between the two electrodes. Hence, in the case of bare GC, the oxidation signal of PIR was very broad and appeared at a high potential (+0.7 V). In contrast, the signal recorded with the NGr/GC electrode was significantly higher (four times) and shifted towards lower potentials (+0.54 V), proving the electro-catalytic effect of nitrogen-doped graphene. The NGr/GC electrode was also tested for its ability to detect piroxicam in pharmaceutical drugs (Flamexin), giving excellent recoveries. |
| first_indexed | 2024-03-09T22:19:41Z |
| format | Article |
| id | doaj.art-e0a686fa74564d43a64adc5f84989f76 |
| institution | Directory Open Access Journal |
| issn | 2227-9040 |
| language | English |
| last_indexed | 2024-03-09T22:19:41Z |
| publishDate | 2022-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Chemosensors |
| spelling | doaj.art-e0a686fa74564d43a64adc5f84989f762023-11-23T19:17:02ZengMDPI AGChemosensors2227-90402022-01-011024710.3390/chemosensors10020047Nitrogen-Doped Graphene-Based Sensor for Electrochemical Detection of Piroxicam, a NSAID Drug for COVID-19 PatientsCodruţa Varodi0Maria Coros1Florina Pogăcean2Alexandra Ciorîţă3Alexandru Turza4Stela Pruneanu5National Institute for Research and Development of Isotopic and Molecular Technologies, Donat Street, 67-103, 400293 Cluj-Napoca, RomaniaNational Institute for Research and Development of Isotopic and Molecular Technologies, Donat Street, 67-103, 400293 Cluj-Napoca, RomaniaNational Institute for Research and Development of Isotopic and Molecular Technologies, Donat Street, 67-103, 400293 Cluj-Napoca, RomaniaNational Institute for Research and Development of Isotopic and Molecular Technologies, Donat Street, 67-103, 400293 Cluj-Napoca, RomaniaNational Institute for Research and Development of Isotopic and Molecular Technologies, Donat Street, 67-103, 400293 Cluj-Napoca, RomaniaNational Institute for Research and Development of Isotopic and Molecular Technologies, Donat Street, 67-103, 400293 Cluj-Napoca, RomaniaNitrogen-doped graphene (NGr) was synthesized by the hydrothermal method using urea as a reducing and doping agent for graphene oxide (GO). The crystalline structure of GO was revealed by the XRD intense peak recorded at 2θ = 11.4°, indicating that the interlayer distance within the structure was large (d = 0.77 nm), and the number of layers (n) was 9. Further, the transformation of GO in NGr also led to the decrease in the interlayer distance and number of layers (d = 0.387 nm; n = 3). As indicated by elemental analysis, the concentration of nitrogen in the NGr sample was 6 wt%. Next, the comparison between the performance of bare GC and the graphene-modified electrode (NGr/GC) towards piroxicam (PIR) detection was studied. Significant differences were observed between the two electrodes. Hence, in the case of bare GC, the oxidation signal of PIR was very broad and appeared at a high potential (+0.7 V). In contrast, the signal recorded with the NGr/GC electrode was significantly higher (four times) and shifted towards lower potentials (+0.54 V), proving the electro-catalytic effect of nitrogen-doped graphene. The NGr/GC electrode was also tested for its ability to detect piroxicam in pharmaceutical drugs (Flamexin), giving excellent recoveries.https://www.mdpi.com/2227-9040/10/2/47piroxicamnitrogen-doped graphenegraphene-modified electrodeselectrochemical detection |
| spellingShingle | Codruţa Varodi Maria Coros Florina Pogăcean Alexandra Ciorîţă Alexandru Turza Stela Pruneanu Nitrogen-Doped Graphene-Based Sensor for Electrochemical Detection of Piroxicam, a NSAID Drug for COVID-19 Patients Chemosensors piroxicam nitrogen-doped graphene graphene-modified electrodes electrochemical detection |
| title | Nitrogen-Doped Graphene-Based Sensor for Electrochemical Detection of Piroxicam, a NSAID Drug for COVID-19 Patients |
| title_full | Nitrogen-Doped Graphene-Based Sensor for Electrochemical Detection of Piroxicam, a NSAID Drug for COVID-19 Patients |
| title_fullStr | Nitrogen-Doped Graphene-Based Sensor for Electrochemical Detection of Piroxicam, a NSAID Drug for COVID-19 Patients |
| title_full_unstemmed | Nitrogen-Doped Graphene-Based Sensor for Electrochemical Detection of Piroxicam, a NSAID Drug for COVID-19 Patients |
| title_short | Nitrogen-Doped Graphene-Based Sensor for Electrochemical Detection of Piroxicam, a NSAID Drug for COVID-19 Patients |
| title_sort | nitrogen doped graphene based sensor for electrochemical detection of piroxicam a nsaid drug for covid 19 patients |
| topic | piroxicam nitrogen-doped graphene graphene-modified electrodes electrochemical detection |
| url | https://www.mdpi.com/2227-9040/10/2/47 |
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