Alcohol Drinking Increased the Risk of Advanced Colorectal Adenomas
Background/AimsAge, sex, gene and life style are modulating risks for colon cancer. Although alcohol intake may impact on colorectal adenoma, clear association has not been established yet. We aimed to investigate effects of alcohol consumption on the characteristics of colorectal adenoma.MethodsPat...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Korean Association for the Study of Intestinal Diseases
2015-01-01
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| Series: | Intestinal Research |
| Subjects: | |
| Online Access: | http://www.irjournal.org/upload/pdf/ir-13-74.pdf |
| _version_ | 1818036398836416512 |
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| author | Yoon Kyung Song Young Sook Park Choon Sik Seon Hye Jin Lim Byung Kwan Son Sang Bong Ahn Young Kwan Jo Seong Hwan Kim Yun Ju Jo Ji Hyun Lee Seung Chan Kim |
| author_facet | Yoon Kyung Song Young Sook Park Choon Sik Seon Hye Jin Lim Byung Kwan Son Sang Bong Ahn Young Kwan Jo Seong Hwan Kim Yun Ju Jo Ji Hyun Lee Seung Chan Kim |
| author_sort | Yoon Kyung Song |
| collection | DOAJ |
| description | Background/AimsAge, sex, gene and life style are modulating risks for colon cancer. Although alcohol intake may impact on colorectal adenoma, clear association has not been established yet. We aimed to investigate effects of alcohol consumption on the characteristics of colorectal adenoma.MethodsPatients who underwent colonoscopic polypectomy of colorectal adenoma in the department of gastroenterology of Eulji hospital through 2005 to 2012, having both blood tests and ultrasound or abdominal CT examination were enrolled. The alcohol drinking patients were subdivided into normal or abnormal laboratory group, and alcoholic liver diseases group.Results212 patients with colorectal adenoma were analyzed; advanced adenoma and multiple adenoma were found in 68 (32.0%) and 79 (37.2%) patients. When compared to the nondrinker group (120/212 patients), the alcohol drinker group (92/212 patients) represented significantly high odds ratios (ORs) for advanced adenoma (OR, 2.697; P=0.002), and multiple adenoma (OR, 1.929; P=0.039). Among alcohol drinker (92 patients), the ORs of advanced adenoma were 6.407 (P=0.003) in alcoholic liver diseases group (17 patients), 3.711 (P=0.002) in the alcohol drinker with abnormal lab (24 patients), and 2.184 (P=0.034), in the alcohol drinker with normal lab (51 patients) compared to nondrinker group.ConclusionsThis study showed that alcohol drinking may influence on the development of advanced colorectal adenoma and multiplicity. Especially in the group with alcoholic liver diseases and with abnormal lab presented significantly higher ORs of advanced adenoma. |
| first_indexed | 2024-12-10T07:10:19Z |
| format | Article |
| id | doaj.art-e0a729e5c3d84faeb1450b02bbbebc76 |
| institution | Directory Open Access Journal |
| issn | 1598-9100 2288-1956 |
| language | English |
| last_indexed | 2024-12-10T07:10:19Z |
| publishDate | 2015-01-01 |
| publisher | Korean Association for the Study of Intestinal Diseases |
| record_format | Article |
| series | Intestinal Research |
| spelling | doaj.art-e0a729e5c3d84faeb1450b02bbbebc762022-12-22T01:58:05ZengKorean Association for the Study of Intestinal DiseasesIntestinal Research1598-91002288-19562015-01-01131747910.5217/ir.2015.13.1.74124Alcohol Drinking Increased the Risk of Advanced Colorectal AdenomasYoon Kyung Song0Young Sook Park1Choon Sik Seon2Hye Jin Lim3Byung Kwan Son4Sang Bong Ahn5Young Kwan Jo6Seong Hwan Kim7Yun Ju Jo8Ji Hyun Lee9Seung Chan Kim10Department of Internal Medicine, Eulji University College of Medicine, Seoul, Korea.Department of Internal Medicine, Eulji University College of Medicine, Seoul, Korea.Department of Internal Medicine, Eulji University College of Medicine, Seoul, Korea.Department of Internal Medicine, Eulji University College of Medicine, Seoul, Korea.Department of Internal Medicine, Eulji University College of Medicine, Seoul, Korea.Department of Internal Medicine, Eulji University College of Medicine, Seoul, Korea.Department of Internal Medicine, Eulji University College of Medicine, Seoul, Korea.Department of Internal Medicine, Eulji University College of Medicine, Seoul, Korea.Department of Internal Medicine, Eulji University College of Medicine, Seoul, Korea.Department of Internal Medicine, Eulji University College of Medicine, Seoul, Korea.Department of Internal Medicine, Eulji University College of Medicine, Seoul, Korea.Background/AimsAge, sex, gene and life style are modulating risks for colon cancer. Although alcohol intake may impact on colorectal adenoma, clear association has not been established yet. We aimed to investigate effects of alcohol consumption on the characteristics of colorectal adenoma.MethodsPatients who underwent colonoscopic polypectomy of colorectal adenoma in the department of gastroenterology of Eulji hospital through 2005 to 2012, having both blood tests and ultrasound or abdominal CT examination were enrolled. The alcohol drinking patients were subdivided into normal or abnormal laboratory group, and alcoholic liver diseases group.Results212 patients with colorectal adenoma were analyzed; advanced adenoma and multiple adenoma were found in 68 (32.0%) and 79 (37.2%) patients. When compared to the nondrinker group (120/212 patients), the alcohol drinker group (92/212 patients) represented significantly high odds ratios (ORs) for advanced adenoma (OR, 2.697; P=0.002), and multiple adenoma (OR, 1.929; P=0.039). Among alcohol drinker (92 patients), the ORs of advanced adenoma were 6.407 (P=0.003) in alcoholic liver diseases group (17 patients), 3.711 (P=0.002) in the alcohol drinker with abnormal lab (24 patients), and 2.184 (P=0.034), in the alcohol drinker with normal lab (51 patients) compared to nondrinker group.ConclusionsThis study showed that alcohol drinking may influence on the development of advanced colorectal adenoma and multiplicity. Especially in the group with alcoholic liver diseases and with abnormal lab presented significantly higher ORs of advanced adenoma.http://www.irjournal.org/upload/pdf/ir-13-74.pdfAdvanced colorectal adenomaAlcohol drinkingRiskLiver diseases, alcoholics |
| spellingShingle | Yoon Kyung Song Young Sook Park Choon Sik Seon Hye Jin Lim Byung Kwan Son Sang Bong Ahn Young Kwan Jo Seong Hwan Kim Yun Ju Jo Ji Hyun Lee Seung Chan Kim Alcohol Drinking Increased the Risk of Advanced Colorectal Adenomas Intestinal Research Advanced colorectal adenoma Alcohol drinking Risk Liver diseases, alcoholics |
| title | Alcohol Drinking Increased the Risk of Advanced Colorectal Adenomas |
| title_full | Alcohol Drinking Increased the Risk of Advanced Colorectal Adenomas |
| title_fullStr | Alcohol Drinking Increased the Risk of Advanced Colorectal Adenomas |
| title_full_unstemmed | Alcohol Drinking Increased the Risk of Advanced Colorectal Adenomas |
| title_short | Alcohol Drinking Increased the Risk of Advanced Colorectal Adenomas |
| title_sort | alcohol drinking increased the risk of advanced colorectal adenomas |
| topic | Advanced colorectal adenoma Alcohol drinking Risk Liver diseases, alcoholics |
| url | http://www.irjournal.org/upload/pdf/ir-13-74.pdf |
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