Arterial switch operation for transposition of great arteries: late results in adult patients

Complete transposition of the great arteries (TGA) accounts for 5% to 7% of congenital cardiac anomalies, and represents the second most common cyanotic heart defect 1, 2. Successful surgery, allowing the majority of patients to survive to adulthood, can either involve a physiologic or anatomic “cor...

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Main Authors: Giancarlo Scognamiglio, Wei Li
Format: Article
Language:English
Published: Barcaray International 2013-01-01
Series:International Cardiovascular Forum Journal
Subjects:
Online Access:http://icfjournal.org/index.php/icfj/article/view/13/10
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author Giancarlo Scognamiglio
Wei Li
author_facet Giancarlo Scognamiglio
Wei Li
author_sort Giancarlo Scognamiglio
collection DOAJ
description Complete transposition of the great arteries (TGA) accounts for 5% to 7% of congenital cardiac anomalies, and represents the second most common cyanotic heart defect 1, 2. Successful surgery, allowing the majority of patients to survive to adulthood, can either involve a physiologic or anatomic “correction”. The former (i.e. atrial switch), introduced in 1958 by Senning and later modified by Mustard, corrects the physiologic abnormality of the TGA by creating an atrial baffle to direct the venous return to the contralateral atrioventricular valve and ventricle3, 4. Although mid-term clinical results are excellent, this procedure leaves the RV supporting the systemic circulation. Hence, complications such as progressive RV dysfunction, ensuing tricuspid regurgitation, frequent arrhythmias, heart failure and early mortality may arise in the long-term5-7.
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spelling doaj.art-e0a7e6834eae4bcb8a65a874f23f42a62022-12-22T03:06:57ZengBarcaray InternationalInternational Cardiovascular Forum Journal2410-26362409-34242013-01-0111815https://doi.org/10.17987/icfj.v1i1.13Arterial switch operation for transposition of great arteries: late results in adult patientsGiancarlo Scognamiglio0Wei Li1Department of Pediatric Cardiology, Second University of Naples, Monaldi Hospital, Naples, Italy.Royal Brompton and Harefield NHS Foundation Trust, Sydney Street, London SW3 6NP, United Kingdom National Heart and Lung Institute, Imperial College London, Dovehouse Street. London SW3 6LY, United Kingdom and NIHR Cardiovascular Biomedical Research Unit, Royal Brompton Hospital and Imperial College London.Complete transposition of the great arteries (TGA) accounts for 5% to 7% of congenital cardiac anomalies, and represents the second most common cyanotic heart defect 1, 2. Successful surgery, allowing the majority of patients to survive to adulthood, can either involve a physiologic or anatomic “correction”. The former (i.e. atrial switch), introduced in 1958 by Senning and later modified by Mustard, corrects the physiologic abnormality of the TGA by creating an atrial baffle to direct the venous return to the contralateral atrioventricular valve and ventricle3, 4. Although mid-term clinical results are excellent, this procedure leaves the RV supporting the systemic circulation. Hence, complications such as progressive RV dysfunction, ensuing tricuspid regurgitation, frequent arrhythmias, heart failure and early mortality may arise in the long-term5-7.http://icfjournal.org/index.php/icfj/article/view/13/10Atrial fibrillationCoronary artery stentanticoagulationdual antiplatelet therapytriple therapy
spellingShingle Giancarlo Scognamiglio
Wei Li
Arterial switch operation for transposition of great arteries: late results in adult patients
International Cardiovascular Forum Journal
Atrial fibrillation
Coronary artery stent
anticoagulation
dual antiplatelet therapy
triple therapy
title Arterial switch operation for transposition of great arteries: late results in adult patients
title_full Arterial switch operation for transposition of great arteries: late results in adult patients
title_fullStr Arterial switch operation for transposition of great arteries: late results in adult patients
title_full_unstemmed Arterial switch operation for transposition of great arteries: late results in adult patients
title_short Arterial switch operation for transposition of great arteries: late results in adult patients
title_sort arterial switch operation for transposition of great arteries late results in adult patients
topic Atrial fibrillation
Coronary artery stent
anticoagulation
dual antiplatelet therapy
triple therapy
url http://icfjournal.org/index.php/icfj/article/view/13/10
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