Use of cervicovaginal PAMG-1 protein as a predictor of delivery within seven days in pregnancies at risk of premature birth
Abstract Background To investigate the utility of vaginal placental alpha microglobulin-1 (PAMG-1) protein as a predictor of preterm delivery within 7 days in pregnancies at risk of premature birth. Methods This prospective study was performed in women at risk of premature birth. The levels of vagin...
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| Format: | Article |
| Language: | English |
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BMC
2017-07-01
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| Series: | BMC Pregnancy and Childbirth |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12884-017-1427-0 |
| _version_ | 1828237439721799680 |
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| author | Yasemin Çekmez Gürkan Kıran Esra Tuştaş Haberal Merve Dizdar |
| author_facet | Yasemin Çekmez Gürkan Kıran Esra Tuştaş Haberal Merve Dizdar |
| author_sort | Yasemin Çekmez |
| collection | DOAJ |
| description | Abstract Background To investigate the utility of vaginal placental alpha microglobulin-1 (PAMG-1) protein as a predictor of preterm delivery within 7 days in pregnancies at risk of premature birth. Methods This prospective study was performed in women at risk of premature birth. The levels of vaginal PAMG-1 and foetal fibronectin (fFN) and the transvaginal cervical length measurement (CLM) were investigated and compared. Results Seventy-two pregnant women were included in this study. The sensitivities of PAMG-1, fFN and CLM were 73.3, 73.6%, and 52.9%, respectively, while the specificities of PAMG-1, fFN and CLM were 92.9%, 94.3%, and 90.9%, respectively. The positive predictive values of PAMG-1, fFN and CLM were 73.3%, 82.3%, and 64.2%, respectively, and the negative predictive values of PAMG-1, fFN and CLM were 92.9%, 90.9%, and 86.2%, respectively. Conclusion The diagnostic accuracy of PAMG-1 is similar to that of fFN in terms of preterm labour detection within 7 days. |
| first_indexed | 2024-04-12T20:48:39Z |
| format | Article |
| id | doaj.art-e0a86f829fbf40f791b7f3bf53d00c0f |
| institution | Directory Open Access Journal |
| issn | 1471-2393 |
| language | English |
| last_indexed | 2024-04-12T20:48:39Z |
| publishDate | 2017-07-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Pregnancy and Childbirth |
| spelling | doaj.art-e0a86f829fbf40f791b7f3bf53d00c0f2022-12-22T03:17:12ZengBMCBMC Pregnancy and Childbirth1471-23932017-07-011711510.1186/s12884-017-1427-0Use of cervicovaginal PAMG-1 protein as a predictor of delivery within seven days in pregnancies at risk of premature birthYasemin Çekmez0Gürkan Kıran1Esra Tuştaş Haberal2Merve Dizdar3Department of Obstetrics and Gynaecology, Umraniye Medical and Research HospitalDepartment of Obstetrics and Gynaecology, Umraniye Medical and Research HospitalDepartment of Obstetrics and Gynaecology, Umraniye Medical and Research HospitalDepartment of Obstetrics and Gynaecology, Umraniye Medical and Research HospitalAbstract Background To investigate the utility of vaginal placental alpha microglobulin-1 (PAMG-1) protein as a predictor of preterm delivery within 7 days in pregnancies at risk of premature birth. Methods This prospective study was performed in women at risk of premature birth. The levels of vaginal PAMG-1 and foetal fibronectin (fFN) and the transvaginal cervical length measurement (CLM) were investigated and compared. Results Seventy-two pregnant women were included in this study. The sensitivities of PAMG-1, fFN and CLM were 73.3, 73.6%, and 52.9%, respectively, while the specificities of PAMG-1, fFN and CLM were 92.9%, 94.3%, and 90.9%, respectively. The positive predictive values of PAMG-1, fFN and CLM were 73.3%, 82.3%, and 64.2%, respectively, and the negative predictive values of PAMG-1, fFN and CLM were 92.9%, 90.9%, and 86.2%, respectively. Conclusion The diagnostic accuracy of PAMG-1 is similar to that of fFN in terms of preterm labour detection within 7 days.http://link.springer.com/article/10.1186/s12884-017-1427-0PAMG-1FibronectinPreterm labourPrematurity |
| spellingShingle | Yasemin Çekmez Gürkan Kıran Esra Tuştaş Haberal Merve Dizdar Use of cervicovaginal PAMG-1 protein as a predictor of delivery within seven days in pregnancies at risk of premature birth BMC Pregnancy and Childbirth PAMG-1 Fibronectin Preterm labour Prematurity |
| title | Use of cervicovaginal PAMG-1 protein as a predictor of delivery within seven days in pregnancies at risk of premature birth |
| title_full | Use of cervicovaginal PAMG-1 protein as a predictor of delivery within seven days in pregnancies at risk of premature birth |
| title_fullStr | Use of cervicovaginal PAMG-1 protein as a predictor of delivery within seven days in pregnancies at risk of premature birth |
| title_full_unstemmed | Use of cervicovaginal PAMG-1 protein as a predictor of delivery within seven days in pregnancies at risk of premature birth |
| title_short | Use of cervicovaginal PAMG-1 protein as a predictor of delivery within seven days in pregnancies at risk of premature birth |
| title_sort | use of cervicovaginal pamg 1 protein as a predictor of delivery within seven days in pregnancies at risk of premature birth |
| topic | PAMG-1 Fibronectin Preterm labour Prematurity |
| url | http://link.springer.com/article/10.1186/s12884-017-1427-0 |
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