Two Uncomplicated Pregnancies on Alectinib in a Woman With Metastatic ALK-Rearranged NSCLC: A Case Report

Lung cancer incidence is increasing in pregnancy due in part to advanced maternal age. A subset of patients with NSCLC during pregnancy harbor an ALK gene rearrangement. Although ALK inhibitors, such as alectinib, are routinely used to treat ALK-rearranged NSCLC, there are limited safety data regard...

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Main Authors: Chloe Weidenbaum, DO, Christopher G. Cann, MD, Sarah Osmundson, MD, MS, Wade T. Iams, MD, MSCI, Travis Osterman, DO, MS
Format: Article
Language:English
Published: Elsevier 2022-08-01
Series:JTO Clinical and Research Reports
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2666364322000856
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author Chloe Weidenbaum, DO
Christopher G. Cann, MD
Sarah Osmundson, MD, MS
Wade T. Iams, MD, MSCI
Travis Osterman, DO, MS
author_facet Chloe Weidenbaum, DO
Christopher G. Cann, MD
Sarah Osmundson, MD, MS
Wade T. Iams, MD, MSCI
Travis Osterman, DO, MS
author_sort Chloe Weidenbaum, DO
collection DOAJ
description Lung cancer incidence is increasing in pregnancy due in part to advanced maternal age. A subset of patients with NSCLC during pregnancy harbor an ALK gene rearrangement. Although ALK inhibitors, such as alectinib, are routinely used to treat ALK-rearranged NSCLC, there are limited safety data regarding use during pregnancy and fetal effects. Here, we report the second case of a patient with metastatic ALK-rearranged lung adenocarcinoma treated with alectinib throughout pregnancy. Notably, the patient had two uncomplicated pregnancies with routine obstetrical and postnatal courses. In this case, alectinib did not seem to affect embryofetal or early childhood development. This does not exclude undetectable or delayed toxic effects, and additional studies are needed to further reveal the safety of alectinib treatment during pregnancy.
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spelling doaj.art-e0ab1a9c91e04b6db186ffa06e744fb82022-12-22T01:41:38ZengElsevierJTO Clinical and Research Reports2666-36432022-08-0138100361Two Uncomplicated Pregnancies on Alectinib in a Woman With Metastatic ALK-Rearranged NSCLC: A Case ReportChloe Weidenbaum, DO0Christopher G. Cann, MD1Sarah Osmundson, MD, MS2Wade T. Iams, MD, MSCI3Travis Osterman, DO, MS4Department of Medicine, University of Tennessee Health Science Center, Nashville, TennesseeDivision of Hematology-Oncology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TennesseeDepartment of Obstetrics and Gynecology, Vanderbilt University Medical Center, Nashville, TennesseeDivision of Hematology-Oncology, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee; Vanderbilt-Ingram Cancer Center, Nashville, Tennessee; Corresponding author. Address for correspondence: Wade T. Iams, MD, MSCI, Vanderbilt-Ingram Cancer Center, 2220 Pierce Avenue, 780 Preston Research Building, Nashville, TN 37232-6307.Division of Hematology-Oncology, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee; Vanderbilt-Ingram Cancer Center, Nashville, TennesseeLung cancer incidence is increasing in pregnancy due in part to advanced maternal age. A subset of patients with NSCLC during pregnancy harbor an ALK gene rearrangement. Although ALK inhibitors, such as alectinib, are routinely used to treat ALK-rearranged NSCLC, there are limited safety data regarding use during pregnancy and fetal effects. Here, we report the second case of a patient with metastatic ALK-rearranged lung adenocarcinoma treated with alectinib throughout pregnancy. Notably, the patient had two uncomplicated pregnancies with routine obstetrical and postnatal courses. In this case, alectinib did not seem to affect embryofetal or early childhood development. This does not exclude undetectable or delayed toxic effects, and additional studies are needed to further reveal the safety of alectinib treatment during pregnancy.http://www.sciencedirect.com/science/article/pii/S2666364322000856ALK-rearranged non–small cell lung cancerPregnancyCase reportAlectinib
spellingShingle Chloe Weidenbaum, DO
Christopher G. Cann, MD
Sarah Osmundson, MD, MS
Wade T. Iams, MD, MSCI
Travis Osterman, DO, MS
Two Uncomplicated Pregnancies on Alectinib in a Woman With Metastatic ALK-Rearranged NSCLC: A Case Report
JTO Clinical and Research Reports
ALK-rearranged non–small cell lung cancer
Pregnancy
Case report
Alectinib
title Two Uncomplicated Pregnancies on Alectinib in a Woman With Metastatic ALK-Rearranged NSCLC: A Case Report
title_full Two Uncomplicated Pregnancies on Alectinib in a Woman With Metastatic ALK-Rearranged NSCLC: A Case Report
title_fullStr Two Uncomplicated Pregnancies on Alectinib in a Woman With Metastatic ALK-Rearranged NSCLC: A Case Report
title_full_unstemmed Two Uncomplicated Pregnancies on Alectinib in a Woman With Metastatic ALK-Rearranged NSCLC: A Case Report
title_short Two Uncomplicated Pregnancies on Alectinib in a Woman With Metastatic ALK-Rearranged NSCLC: A Case Report
title_sort two uncomplicated pregnancies on alectinib in a woman with metastatic alk rearranged nsclc a case report
topic ALK-rearranged non–small cell lung cancer
Pregnancy
Case report
Alectinib
url http://www.sciencedirect.com/science/article/pii/S2666364322000856
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