Competing Endogenous RNA Networks in the Epithelial to Mesenchymal Transition in Diffuse-Type of Gastric Cancer
The diffuse-type of gastric cancer (DGC), molecularly associated with epithelial to mesenchymal transition (EMT), is increasing in incidence. Loss of E-cadherin expression is the hallmark of the EMT process and is largely due to the upregulation of the EMT-inducing transcription factors ZEB1/2, Snai...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2020-09-01
|
| Series: | Cancers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6694/12/10/2741 |
| _version_ | 1797552792147066880 |
|---|---|
| author | Natalia Landeros Pablo M. Santoro Gonzalo Carrasco-Avino Alejandro H. Corvalan |
| author_facet | Natalia Landeros Pablo M. Santoro Gonzalo Carrasco-Avino Alejandro H. Corvalan |
| author_sort | Natalia Landeros |
| collection | DOAJ |
| description | The diffuse-type of gastric cancer (DGC), molecularly associated with epithelial to mesenchymal transition (EMT), is increasing in incidence. Loss of E-cadherin expression is the hallmark of the EMT process and is largely due to the upregulation of the EMT-inducing transcription factors ZEB1/2, Snail, Slug, and Twist1/2. However, ncRNA, such as miRNA and lncRNAs, can also participate in the EMT process through the direct targeting of E-cadherin and other EMT-inducing transcription factors. Additionally, lncRNA can sponge the miRNA pool that targets these transcripts through competing endogenous RNA (ceRNA) networks. In this review, we focus on the role of ncRNA in the direct deregulation of E-cadherin, as well as EMT-inducing transcription factors. Based on the relevance of the ceRNA network hypothesis, and the lack of said networks in EMT, we performed a prediction analysis for all miRNAs and lncRNAs that target E-cadherin, as well as EMT-inducing transcription factors. This analysis resulted in novel predicted ceRNA networks for E-cadherin and EMT-inducing transcription factors (EMT-TFs), as well as the expansion of the molecular basis of the DGC. |
| first_indexed | 2024-03-10T16:06:04Z |
| format | Article |
| id | doaj.art-e0ab5d965d7c4eb481676e4b25c195a6 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T16:06:04Z |
| publishDate | 2020-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-e0ab5d965d7c4eb481676e4b25c195a62023-11-20T14:55:20ZengMDPI AGCancers2072-66942020-09-011210274110.3390/cancers12102741Competing Endogenous RNA Networks in the Epithelial to Mesenchymal Transition in Diffuse-Type of Gastric CancerNatalia Landeros0Pablo M. Santoro1Gonzalo Carrasco-Avino2Alejandro H. Corvalan3Advanced Center for Chronic Diseases, Pontificia Universidad Católica de Chile, Santiago 8330034, ChileAdvanced Center for Chronic Diseases, Pontificia Universidad Católica de Chile, Santiago 8330034, ChileDepartment of Pathology, Hospital Clinico Universidad de Chile and Clinica Las Condes, Santiago 7550000, ChileAdvanced Center for Chronic Diseases, Pontificia Universidad Católica de Chile, Santiago 8330034, ChileThe diffuse-type of gastric cancer (DGC), molecularly associated with epithelial to mesenchymal transition (EMT), is increasing in incidence. Loss of E-cadherin expression is the hallmark of the EMT process and is largely due to the upregulation of the EMT-inducing transcription factors ZEB1/2, Snail, Slug, and Twist1/2. However, ncRNA, such as miRNA and lncRNAs, can also participate in the EMT process through the direct targeting of E-cadherin and other EMT-inducing transcription factors. Additionally, lncRNA can sponge the miRNA pool that targets these transcripts through competing endogenous RNA (ceRNA) networks. In this review, we focus on the role of ncRNA in the direct deregulation of E-cadherin, as well as EMT-inducing transcription factors. Based on the relevance of the ceRNA network hypothesis, and the lack of said networks in EMT, we performed a prediction analysis for all miRNAs and lncRNAs that target E-cadherin, as well as EMT-inducing transcription factors. This analysis resulted in novel predicted ceRNA networks for E-cadherin and EMT-inducing transcription factors (EMT-TFs), as well as the expansion of the molecular basis of the DGC.https://www.mdpi.com/2072-6694/12/10/2741diffuse-type gastric cancerepithelial to mesenchymal transitionE-cadherinEMT-inducing transcription factorsmicroRNAlong non-coding RNA |
| spellingShingle | Natalia Landeros Pablo M. Santoro Gonzalo Carrasco-Avino Alejandro H. Corvalan Competing Endogenous RNA Networks in the Epithelial to Mesenchymal Transition in Diffuse-Type of Gastric Cancer Cancers diffuse-type gastric cancer epithelial to mesenchymal transition E-cadherin EMT-inducing transcription factors microRNA long non-coding RNA |
| title | Competing Endogenous RNA Networks in the Epithelial to Mesenchymal Transition in Diffuse-Type of Gastric Cancer |
| title_full | Competing Endogenous RNA Networks in the Epithelial to Mesenchymal Transition in Diffuse-Type of Gastric Cancer |
| title_fullStr | Competing Endogenous RNA Networks in the Epithelial to Mesenchymal Transition in Diffuse-Type of Gastric Cancer |
| title_full_unstemmed | Competing Endogenous RNA Networks in the Epithelial to Mesenchymal Transition in Diffuse-Type of Gastric Cancer |
| title_short | Competing Endogenous RNA Networks in the Epithelial to Mesenchymal Transition in Diffuse-Type of Gastric Cancer |
| title_sort | competing endogenous rna networks in the epithelial to mesenchymal transition in diffuse type of gastric cancer |
| topic | diffuse-type gastric cancer epithelial to mesenchymal transition E-cadherin EMT-inducing transcription factors microRNA long non-coding RNA |
| url | https://www.mdpi.com/2072-6694/12/10/2741 |
| work_keys_str_mv | AT natalialanderos competingendogenousrnanetworksintheepithelialtomesenchymaltransitionindiffusetypeofgastriccancer AT pablomsantoro competingendogenousrnanetworksintheepithelialtomesenchymaltransitionindiffusetypeofgastriccancer AT gonzalocarrascoavino competingendogenousrnanetworksintheepithelialtomesenchymaltransitionindiffusetypeofgastriccancer AT alejandrohcorvalan competingendogenousrnanetworksintheepithelialtomesenchymaltransitionindiffusetypeofgastriccancer |