The Structural Basis of African Swine Fever Virus pS273R Protease Binding to E64 through Molecular Dynamics Simulations

The Structural Basis of African Swine Fever Virus pS273R Protease Binding to E64 through Molecular Dynamics Simulations

Identification of novel drugs for anti-African swine fever (ASF) applications is of utmost urgency, as it negatively affects pig farming and no effective vaccine or treatment is currently available. African swine fever virus (ASFV) encoded pS273R is a cysteine protease that plays an important role i...

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Bibliographic Details
Main Authors: Gen Lu, Kang Ou, Yiwen Jing, Huan Zhang, Shouhua Feng, Zuofeng Yang, Guoshun Shen, Jinling Liu, Changde Wu, Shu Wei
Format: Article
Language:English
Published: MDPI AG 2023-02-01
Series:Molecules
Subjects:
pS273R protease
molecular docking
E64
molecular dynamic simulation
African swine fever virus
Online Access:https://www.mdpi.com/1420-3049/28/3/1435

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