The Effect of Two-Generation Exposure to a High-Fat Diet on Craniofacial Morphology in Rats
This study aimed to examine the sexual dimorphism effect of two-generation exposure to a high-fat diet (HFD) on the craniofacial growth of rat offspring. Ten eleven-week-old pregnant Wistar rats were fed either a control or HFD from day 7 of pregnancy until the end of lactation. Twelve male and fema...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-02-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/12/5/1903 |
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| author | Saranya Serirukchutarungsee Ippei Watari Pornchanok Sangsuriyothai Masato Akakura Takashi Ono |
| author_facet | Saranya Serirukchutarungsee Ippei Watari Pornchanok Sangsuriyothai Masato Akakura Takashi Ono |
| author_sort | Saranya Serirukchutarungsee |
| collection | DOAJ |
| description | This study aimed to examine the sexual dimorphism effect of two-generation exposure to a high-fat diet (HFD) on the craniofacial growth of rat offspring. Ten eleven-week-old pregnant Wistar rats were fed either a control or HFD from day 7 of pregnancy until the end of lactation. Twelve male and female offspring from the control-diet-fed mothers were assigned to the CM (control male, n = 6) and CF (control female, n = 6) groups. The other twelve from the HFD-fed mothers were assigned to the HFD male (HFDM, n = 6) and HFD female (HFDF, n = 6) groups. HFDM and HFDF rats continued with an HFD. The offspring’s weight and fasting blood sugar levels were measured every two weeks. The craniofacial and dental morphologies were studied from lateral X-rays of the head at ten weeks old. The HFDM rats showed an increased body weight and larger neurocranial parameters compared with the CM group. Furthermore, there were slightly significant differences in body weight and viscerocranial parameters between the rats in the HFDF and CF groups. In conclusion, two-generational exposure to an HFD had a greater effect on the male offspring’s body weight and craniofacial morphology. |
| first_indexed | 2024-03-11T07:21:00Z |
| format | Article |
| id | doaj.art-e0acdb83bbd3410bbee94372f807633e |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-11T07:21:00Z |
| publishDate | 2023-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-e0acdb83bbd3410bbee94372f807633e2023-11-17T07:59:55ZengMDPI AGJournal of Clinical Medicine2077-03832023-02-01125190310.3390/jcm12051903The Effect of Two-Generation Exposure to a High-Fat Diet on Craniofacial Morphology in RatsSaranya Serirukchutarungsee0Ippei Watari1Pornchanok Sangsuriyothai2Masato Akakura3Takashi Ono4Department of Orthodontic Science, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Tokyo 113-8510, JapanDepartment of Orthodontic Science, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Tokyo 113-8510, JapanDepartment of Orthodontic Science, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Tokyo 113-8510, JapanDepartment of Orthodontic Science, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Tokyo 113-8510, JapanDepartment of Orthodontic Science, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Tokyo 113-8510, JapanThis study aimed to examine the sexual dimorphism effect of two-generation exposure to a high-fat diet (HFD) on the craniofacial growth of rat offspring. Ten eleven-week-old pregnant Wistar rats were fed either a control or HFD from day 7 of pregnancy until the end of lactation. Twelve male and female offspring from the control-diet-fed mothers were assigned to the CM (control male, n = 6) and CF (control female, n = 6) groups. The other twelve from the HFD-fed mothers were assigned to the HFD male (HFDM, n = 6) and HFD female (HFDF, n = 6) groups. HFDM and HFDF rats continued with an HFD. The offspring’s weight and fasting blood sugar levels were measured every two weeks. The craniofacial and dental morphologies were studied from lateral X-rays of the head at ten weeks old. The HFDM rats showed an increased body weight and larger neurocranial parameters compared with the CM group. Furthermore, there were slightly significant differences in body weight and viscerocranial parameters between the rats in the HFDF and CF groups. In conclusion, two-generational exposure to an HFD had a greater effect on the male offspring’s body weight and craniofacial morphology.https://www.mdpi.com/2077-0383/12/5/1903high-fat dietpregnancylactationcraniofacial growthcephalometric analysis |
| spellingShingle | Saranya Serirukchutarungsee Ippei Watari Pornchanok Sangsuriyothai Masato Akakura Takashi Ono The Effect of Two-Generation Exposure to a High-Fat Diet on Craniofacial Morphology in Rats Journal of Clinical Medicine high-fat diet pregnancy lactation craniofacial growth cephalometric analysis |
| title | The Effect of Two-Generation Exposure to a High-Fat Diet on Craniofacial Morphology in Rats |
| title_full | The Effect of Two-Generation Exposure to a High-Fat Diet on Craniofacial Morphology in Rats |
| title_fullStr | The Effect of Two-Generation Exposure to a High-Fat Diet on Craniofacial Morphology in Rats |
| title_full_unstemmed | The Effect of Two-Generation Exposure to a High-Fat Diet on Craniofacial Morphology in Rats |
| title_short | The Effect of Two-Generation Exposure to a High-Fat Diet on Craniofacial Morphology in Rats |
| title_sort | effect of two generation exposure to a high fat diet on craniofacial morphology in rats |
| topic | high-fat diet pregnancy lactation craniofacial growth cephalometric analysis |
| url | https://www.mdpi.com/2077-0383/12/5/1903 |
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