Efficacy of oral Cynara scolymus and Silybum marianum on toxicity of imidocarb dipropionate in horses
Background Despite hepatotoxic effects, imidocarb dipropionate is the drug of choice for treatment of equine piroplasmosis. It is important, therefore, to identify adjuvant therapies that may improve the safety of imidocarb dipropionate by reducing the risk of liver damage during its use. The aim of...
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| Format: | Article |
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Wiley
2020-12-01
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| Series: | Veterinary Record Open |
| Online Access: | https://vetrecordopen.bmj.com/content/7/1/e000416.full |
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| author | Fernando Mosquera Jaramillo Diego Darley Velasquez Piñeros Rodrigo Romero Corrêa Fabio Celidonio Pogliani Bruno Cogliati Raquel Yvonne Arantes Baccarin |
| author_facet | Fernando Mosquera Jaramillo Diego Darley Velasquez Piñeros Rodrigo Romero Corrêa Fabio Celidonio Pogliani Bruno Cogliati Raquel Yvonne Arantes Baccarin |
| author_sort | Fernando Mosquera Jaramillo |
| collection | DOAJ |
| description | Background Despite hepatotoxic effects, imidocarb dipropionate is the drug of choice for treatment of equine piroplasmosis. It is important, therefore, to identify adjuvant therapies that may improve the safety of imidocarb dipropionate by reducing the risk of liver damage during its use. The aim of the present study was to evaluate the hepatoprotective and hepatoregulatory effects of treatment with Cynara scolymus and Silybum marianum during administration of imidocarb dipropionate.Methods Ten healthy horses, seroconverted to Theileria equi by C-ELISA, were treated with 5 mg/kg/day of imidocarb dipropionate for three consecutive days. The study population was divided into two groups. The control group did not receive any complementary treatments. The treated group received a daily oral supplement containing C scolymus and S marianum for 30 days. Physical, haematological and histological examinations of hepatic fragments were performed.Results All haematological values remained within normal range for the study population. Histological analysis revealed that treated group animals had 62 per cent less lobular inflammation, 55 per cent less pigment accumulation, 65 per cent less steatosis and 57 per cent less portal inflammation than control group animals, with an equivalent percentage of hydropic degeneration.Conclusion C scolymus and S marianum supplements resulted in beneficial hepatoprotective effects in horses treated with imidocarb dipropionate. |
| first_indexed | 2024-12-17T07:49:22Z |
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| institution | Directory Open Access Journal |
| issn | 2052-6113 |
| language | English |
| last_indexed | 2024-12-17T07:49:22Z |
| publishDate | 2020-12-01 |
| publisher | Wiley |
| record_format | Article |
| series | Veterinary Record Open |
| spelling | doaj.art-e0ae338bca3c46fb83a525becb8973012022-12-21T21:57:54ZengWileyVeterinary Record Open2052-61132020-12-017110.1136/vetreco-2020-000416Efficacy of oral Cynara scolymus and Silybum marianum on toxicity of imidocarb dipropionate in horsesFernando Mosquera Jaramillo0Diego Darley Velasquez Piñeros1Rodrigo Romero Corrêa2Fabio Celidonio Pogliani3Bruno Cogliati4Raquel Yvonne Arantes Baccarin5Departamento de Clínica Médica, Universidade de São Paulo Faculdade de Medicina Veterinária e Zootecnia, Sao Paulo, BrazilDepartamento de Cirurgia, Universidade de São Paulo Faculdade de Medicina Veterinária e Zootecnia, Sao Paulo, BrazilDepartamento de Cirurgia, Universidade de São Paulo Faculdade de Medicina Veterinária e Zootecnia, Sao Paulo, BrazilDepartamento de Clínica Médica, Universidade de São Paulo Faculdade de Medicina Veterinária e Zootecnia, Sao Paulo, BrazilDepartamento de Patologia, Universidade de São Paulo Faculdade de Medicina Veterinária e Zootecnia, Sao Paulo, BrazilDepartamento de Clínica Médica, Universidade de São Paulo Faculdade de Medicina Veterinária e Zootecnia, Sao Paulo, BrazilBackground Despite hepatotoxic effects, imidocarb dipropionate is the drug of choice for treatment of equine piroplasmosis. It is important, therefore, to identify adjuvant therapies that may improve the safety of imidocarb dipropionate by reducing the risk of liver damage during its use. The aim of the present study was to evaluate the hepatoprotective and hepatoregulatory effects of treatment with Cynara scolymus and Silybum marianum during administration of imidocarb dipropionate.Methods Ten healthy horses, seroconverted to Theileria equi by C-ELISA, were treated with 5 mg/kg/day of imidocarb dipropionate for three consecutive days. The study population was divided into two groups. The control group did not receive any complementary treatments. The treated group received a daily oral supplement containing C scolymus and S marianum for 30 days. Physical, haematological and histological examinations of hepatic fragments were performed.Results All haematological values remained within normal range for the study population. Histological analysis revealed that treated group animals had 62 per cent less lobular inflammation, 55 per cent less pigment accumulation, 65 per cent less steatosis and 57 per cent less portal inflammation than control group animals, with an equivalent percentage of hydropic degeneration.Conclusion C scolymus and S marianum supplements resulted in beneficial hepatoprotective effects in horses treated with imidocarb dipropionate.https://vetrecordopen.bmj.com/content/7/1/e000416.full |
| spellingShingle | Fernando Mosquera Jaramillo Diego Darley Velasquez Piñeros Rodrigo Romero Corrêa Fabio Celidonio Pogliani Bruno Cogliati Raquel Yvonne Arantes Baccarin Efficacy of oral Cynara scolymus and Silybum marianum on toxicity of imidocarb dipropionate in horses Veterinary Record Open |
| title | Efficacy of oral Cynara scolymus and Silybum marianum on toxicity of imidocarb dipropionate in horses |
| title_full | Efficacy of oral Cynara scolymus and Silybum marianum on toxicity of imidocarb dipropionate in horses |
| title_fullStr | Efficacy of oral Cynara scolymus and Silybum marianum on toxicity of imidocarb dipropionate in horses |
| title_full_unstemmed | Efficacy of oral Cynara scolymus and Silybum marianum on toxicity of imidocarb dipropionate in horses |
| title_short | Efficacy of oral Cynara scolymus and Silybum marianum on toxicity of imidocarb dipropionate in horses |
| title_sort | efficacy of oral cynara scolymus and silybum marianum on toxicity of imidocarb dipropionate in horses |
| url | https://vetrecordopen.bmj.com/content/7/1/e000416.full |
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