Genetic variant panel allows predicting both obesity risk, and efficacy of procedures and diet in weight loss
PurposeObesity is a multifactorial condition with a relevant genetic correlation. Recent advances in genomic research have identified several single nucleotide polymorphisms (SNPs) in genes such as FTO, MCM6, HLA, and MC4R, associated with obesity. This study aimed to evaluate the association of 102...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-11-01
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| Series: | Frontiers in Nutrition |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2023.1274662/full |
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| author | Alejandra Mera-Charria Francisco Nieto-Lopez Francisco Nieto-Lopez Manel Pacareu Francès Priscila Marques Arbex Laura Vila-Vecilla Valentina Russo Carolina Costa Vicente Silva Gustavo Torres De Souza |
| author_facet | Alejandra Mera-Charria Francisco Nieto-Lopez Francisco Nieto-Lopez Manel Pacareu Francès Priscila Marques Arbex Laura Vila-Vecilla Valentina Russo Carolina Costa Vicente Silva Gustavo Torres De Souza |
| author_sort | Alejandra Mera-Charria |
| collection | DOAJ |
| description | PurposeObesity is a multifactorial condition with a relevant genetic correlation. Recent advances in genomic research have identified several single nucleotide polymorphisms (SNPs) in genes such as FTO, MCM6, HLA, and MC4R, associated with obesity. This study aimed to evaluate the association of 102 SNPs with BMI and weight loss treatment response in a multi-ethnic population.MethodsThe study analyzed 9,372 patients for the correlation between SNPs and BMI (dataset A). The correlation between SNP and weight loss was accessed in 474 patients undergoing different treatments (dataset B). Patients in dataset B were further divided into 3 categories based on the type of intervention: dietary therapy, intragastric balloon procedures, or surgeries. SNP association analysis and multiple models of inheritance were performed.ResultsIn dataset A, ten SNPs, including rs9939609 (FTO), rs4988235 (MCM6), and rs2395182 (HLA), were significantly associated with increased BMI. Additionally, other four SNPs, rs7903146 (TCF7L2), (rs6511720), rs5400 (SLC2A2), and rs7498665 (SH2B1), showed sex-specific correlation. For dataset B, SNPs rs2016520 (PPAR-Delta) and rs2419621 (ACSL5) demonstrated significant correlation with weight loss for all treatment types. In patients who adhered to dietary therapy, SNPs rs6544713 (ABCG8) and rs762551 (CYP1A2) were strongly correlated with weight loss. Patients undergoing surgical or endoscopic procedures exhibited differential correlations with several SNPs, including rs1801725 (CASR) and rs12970134 (MC4R), and weight loss.ConclusionThis study provides valuable insights into the genetic factors influencing BMI and weight loss response to different treatments. The findings highlight the potential for personalized weight management approaches based on individual genetic profiles. |
| first_indexed | 2024-03-11T09:23:37Z |
| format | Article |
| id | doaj.art-e0af20b86b4a4030b08a0a839e7f0dd8 |
| institution | Directory Open Access Journal |
| issn | 2296-861X |
| language | English |
| last_indexed | 2024-03-11T09:23:37Z |
| publishDate | 2023-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Nutrition |
| spelling | doaj.art-e0af20b86b4a4030b08a0a839e7f0dd82023-11-16T18:10:12ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2023-11-011010.3389/fnut.2023.12746621274662Genetic variant panel allows predicting both obesity risk, and efficacy of procedures and diet in weight lossAlejandra Mera-Charria0Francisco Nieto-Lopez1Francisco Nieto-Lopez2Manel Pacareu Francès3Priscila Marques Arbex4Laura Vila-Vecilla5Valentina Russo6Carolina Costa Vicente Silva7Gustavo Torres De Souza8Dorsia Clinics, Madrid, SpainDorsia Clinics, Madrid, SpainCatedra UCAM Dorsia, Catholic University San Antonio of Murcia, Guadalupe, SpainIndependent Researcher, Barcelona, SpainFagron Genomics US, LLC, Austin, TX, United StatesFagron Genomics, Barcelona, SpainFagron Genomics, Barcelona, SpainFagron (Netherlands), Rotterdam, NetherlandsFagron Genomics, Barcelona, SpainPurposeObesity is a multifactorial condition with a relevant genetic correlation. Recent advances in genomic research have identified several single nucleotide polymorphisms (SNPs) in genes such as FTO, MCM6, HLA, and MC4R, associated with obesity. This study aimed to evaluate the association of 102 SNPs with BMI and weight loss treatment response in a multi-ethnic population.MethodsThe study analyzed 9,372 patients for the correlation between SNPs and BMI (dataset A). The correlation between SNP and weight loss was accessed in 474 patients undergoing different treatments (dataset B). Patients in dataset B were further divided into 3 categories based on the type of intervention: dietary therapy, intragastric balloon procedures, or surgeries. SNP association analysis and multiple models of inheritance were performed.ResultsIn dataset A, ten SNPs, including rs9939609 (FTO), rs4988235 (MCM6), and rs2395182 (HLA), were significantly associated with increased BMI. Additionally, other four SNPs, rs7903146 (TCF7L2), (rs6511720), rs5400 (SLC2A2), and rs7498665 (SH2B1), showed sex-specific correlation. For dataset B, SNPs rs2016520 (PPAR-Delta) and rs2419621 (ACSL5) demonstrated significant correlation with weight loss for all treatment types. In patients who adhered to dietary therapy, SNPs rs6544713 (ABCG8) and rs762551 (CYP1A2) were strongly correlated with weight loss. Patients undergoing surgical or endoscopic procedures exhibited differential correlations with several SNPs, including rs1801725 (CASR) and rs12970134 (MC4R), and weight loss.ConclusionThis study provides valuable insights into the genetic factors influencing BMI and weight loss response to different treatments. The findings highlight the potential for personalized weight management approaches based on individual genetic profiles.https://www.frontiersin.org/articles/10.3389/fnut.2023.1274662/fullobesityweight lossgeneticssingle nucleotide polymorphismbariatric surgery |
| spellingShingle | Alejandra Mera-Charria Francisco Nieto-Lopez Francisco Nieto-Lopez Manel Pacareu Francès Priscila Marques Arbex Laura Vila-Vecilla Valentina Russo Carolina Costa Vicente Silva Gustavo Torres De Souza Genetic variant panel allows predicting both obesity risk, and efficacy of procedures and diet in weight loss Frontiers in Nutrition obesity weight loss genetics single nucleotide polymorphism bariatric surgery |
| title | Genetic variant panel allows predicting both obesity risk, and efficacy of procedures and diet in weight loss |
| title_full | Genetic variant panel allows predicting both obesity risk, and efficacy of procedures and diet in weight loss |
| title_fullStr | Genetic variant panel allows predicting both obesity risk, and efficacy of procedures and diet in weight loss |
| title_full_unstemmed | Genetic variant panel allows predicting both obesity risk, and efficacy of procedures and diet in weight loss |
| title_short | Genetic variant panel allows predicting both obesity risk, and efficacy of procedures and diet in weight loss |
| title_sort | genetic variant panel allows predicting both obesity risk and efficacy of procedures and diet in weight loss |
| topic | obesity weight loss genetics single nucleotide polymorphism bariatric surgery |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2023.1274662/full |
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