Association of air pollution with postmenopausal breast cancer risk in UK Biobank
Abstract Background We investigated the association of several air pollution measures with postmenopausal breast cancer (BCa) risk. Methods This study included 155,235 postmenopausal women (of which 6146 with BCa) from UK Biobank. Cancer diagnoses were ascertained through the linkage to the UK Natio...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-07-01
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| Series: | Breast Cancer Research |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13058-023-01681-w |
| _version_ | 1797778665511059456 |
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| author | Carmen Smotherman Brian Sprague Susmita Datta Dejana Braithwaite Huaizhen Qin Lusine Yaghjyan |
| author_facet | Carmen Smotherman Brian Sprague Susmita Datta Dejana Braithwaite Huaizhen Qin Lusine Yaghjyan |
| author_sort | Carmen Smotherman |
| collection | DOAJ |
| description | Abstract Background We investigated the association of several air pollution measures with postmenopausal breast cancer (BCa) risk. Methods This study included 155,235 postmenopausal women (of which 6146 with BCa) from UK Biobank. Cancer diagnoses were ascertained through the linkage to the UK National Health Service Central Registers. Annual exposure averages were available from 2005, 2006, 2007, and 2010 for NO2, from 2007 and 2010 for PM10, and from 2010 for PM2.5, NOX, PM2.5–10 and PM2.5 absorbance. Information on BCa risk factors was collected at baseline. Cox proportional hazards regression was used to evaluate the associations of year-specific and cumulative average exposures with BCa risk, overall and with 2-year exposure lag, while adjusting for BCa risk factors. Results PM10 in 2007 and cumulative average PM10 were positively associated with BCa risk (2007 PM10: Hazard ratio [HR] per 10 µg/m3 = 1.18, 95% CI 1.08, 1.29; cumulative average PM10: HR per 10 µg/m3 = 1.99, 95% CI 1.75, 2.27). Compared to women with low exposure, women with higher 2007 PM10 and cumulative average PM10 had greater BCa risk (4th vs. 1st quartile HR = 1.15, 95% CI 1.07, 1.24, p-trend = 0.001 and HR = 1.35, 95% CI 1.25, 1.44, p-trend < 0.0001, respectively). No significant associations were found for any other exposure measures. In the analysis with 2-year exposure lag, both 2007 PM 10 and cumulative average PM10 were positively associated with BCa risk (4th vs. 1st quartile HR = 1.19, 95% CI 1.10, 1.28 and HR = 1.29, 95% CI 1.19, 1.39, respectively). Conclusion Our findings suggest a positive association of 2007 PM10 and cumulative average PM10 with postmenopausal BCa risk. |
| first_indexed | 2024-03-12T23:19:48Z |
| format | Article |
| id | doaj.art-e0afeeb054d74bd59e2981553c9974f7 |
| institution | Directory Open Access Journal |
| issn | 1465-542X |
| language | English |
| last_indexed | 2024-03-12T23:19:48Z |
| publishDate | 2023-07-01 |
| publisher | BMC |
| record_format | Article |
| series | Breast Cancer Research |
| spelling | doaj.art-e0afeeb054d74bd59e2981553c9974f72023-07-16T11:31:59ZengBMCBreast Cancer Research1465-542X2023-07-0125111410.1186/s13058-023-01681-wAssociation of air pollution with postmenopausal breast cancer risk in UK BiobankCarmen Smotherman0Brian Sprague1Susmita Datta2Dejana Braithwaite3Huaizhen Qin4Lusine Yaghjyan5Department of Epidemiology, College of Public Health and Health Professions and College of Medicine, University of FloridaDepartment of Surgery, University of VermontDepartment of Biostatistics, College of Public Health and Health Professions and College of Medicine, University of FloridaDepartment of Epidemiology, College of Public Health and Health Professions and College of Medicine, University of FloridaDepartment of Epidemiology, College of Public Health and Health Professions and College of Medicine, University of FloridaDepartment of Epidemiology, College of Public Health and Health Professions and College of Medicine, University of FloridaAbstract Background We investigated the association of several air pollution measures with postmenopausal breast cancer (BCa) risk. Methods This study included 155,235 postmenopausal women (of which 6146 with BCa) from UK Biobank. Cancer diagnoses were ascertained through the linkage to the UK National Health Service Central Registers. Annual exposure averages were available from 2005, 2006, 2007, and 2010 for NO2, from 2007 and 2010 for PM10, and from 2010 for PM2.5, NOX, PM2.5–10 and PM2.5 absorbance. Information on BCa risk factors was collected at baseline. Cox proportional hazards regression was used to evaluate the associations of year-specific and cumulative average exposures with BCa risk, overall and with 2-year exposure lag, while adjusting for BCa risk factors. Results PM10 in 2007 and cumulative average PM10 were positively associated with BCa risk (2007 PM10: Hazard ratio [HR] per 10 µg/m3 = 1.18, 95% CI 1.08, 1.29; cumulative average PM10: HR per 10 µg/m3 = 1.99, 95% CI 1.75, 2.27). Compared to women with low exposure, women with higher 2007 PM10 and cumulative average PM10 had greater BCa risk (4th vs. 1st quartile HR = 1.15, 95% CI 1.07, 1.24, p-trend = 0.001 and HR = 1.35, 95% CI 1.25, 1.44, p-trend < 0.0001, respectively). No significant associations were found for any other exposure measures. In the analysis with 2-year exposure lag, both 2007 PM 10 and cumulative average PM10 were positively associated with BCa risk (4th vs. 1st quartile HR = 1.19, 95% CI 1.10, 1.28 and HR = 1.29, 95% CI 1.19, 1.39, respectively). Conclusion Our findings suggest a positive association of 2007 PM10 and cumulative average PM10 with postmenopausal BCa risk.https://doi.org/10.1186/s13058-023-01681-wAir pollutionBreast cancerUK BiobankProspective cohort |
| spellingShingle | Carmen Smotherman Brian Sprague Susmita Datta Dejana Braithwaite Huaizhen Qin Lusine Yaghjyan Association of air pollution with postmenopausal breast cancer risk in UK Biobank Breast Cancer Research Air pollution Breast cancer UK Biobank Prospective cohort |
| title | Association of air pollution with postmenopausal breast cancer risk in UK Biobank |
| title_full | Association of air pollution with postmenopausal breast cancer risk in UK Biobank |
| title_fullStr | Association of air pollution with postmenopausal breast cancer risk in UK Biobank |
| title_full_unstemmed | Association of air pollution with postmenopausal breast cancer risk in UK Biobank |
| title_short | Association of air pollution with postmenopausal breast cancer risk in UK Biobank |
| title_sort | association of air pollution with postmenopausal breast cancer risk in uk biobank |
| topic | Air pollution Breast cancer UK Biobank Prospective cohort |
| url | https://doi.org/10.1186/s13058-023-01681-w |
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