CLINICAL SIGNIFICANCE OF THE TP53 MUTATION STATUS IN DIFFUSE LARGE B-CELL LYMPHOMA
Objective: to reveal the clinical significance of the mutation status of the TP53 gene in the group of receiving rituximab therapy patients with diffuse large B-cell lymphoma (DLBCL) in Novosibirsk. Material and methods. A total of 74 patients with DLBCL, who have been hospitalized at the City Hemat...
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| Format: | Article |
| Language: | Russian |
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Russian Academy of Sciences, Siberian Branch Publishing House
2019-03-01
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| Series: | Сибирский научный медицинский журнал |
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| Online Access: | https://sibmed.elpub.ru/jour/article/view/105 |
| _version_ | 1826575790612938752 |
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| author | E. N. Voropaeva T. I. Pospelova M. I. Voevoda V. N. Maksimov |
| author_facet | E. N. Voropaeva T. I. Pospelova M. I. Voevoda V. N. Maksimov |
| author_sort | E. N. Voropaeva |
| collection | DOAJ |
| description | Objective: to reveal the clinical significance of the mutation status of the TP53 gene in the group of receiving rituximab therapy patients with diffuse large B-cell lymphoma (DLBCL) in Novosibirsk. Material and methods. A total of 74 patients with DLBCL, who have been hospitalized at the City Hematology Center in Novosibirsk for the period 2012–2015, were examined. All patients received therapy with rituximab. The nucleotide sequence of the coding region of the TP53 gene (exons 5–10) and adjacent regions of introns was analyzed by the Sanger direct capillary sequencing. Functional analysis of the revealed mutations was carried out. The results of the patients` therapy were evaluated. Results and discussion. For the first time, it has been revealed in the course of the study of Russian patients with DLBCL setting that TP53 mutation status is associated with the greater incidence of B-symptoms, splenomegaly, leukemia of the lymphoma, and poor prognostic groups according to the International Prognostic Index. A tendency toward a greater frequency of achieving complete clinical and hematologic remission during the therapy was revealed in the subgroup of patients with DLBCL having a canonical sequence of a gene or a mutation in TP53 with an unproven oncogenic potential. Patients with functionally significant TP53 mutations had a lower overall survival rates. Conclusion. For this reason, hopefully therapeutic approaches aimed at the inactivated pathway of TP53 can further improve clinical outcomes in DLBCL. |
| first_indexed | 2024-03-08T14:34:35Z |
| format | Article |
| id | doaj.art-e0b18696b9984da9ae8d19877fb50385 |
| institution | Directory Open Access Journal |
| issn | 2410-2512 2410-2520 |
| language | Russian |
| last_indexed | 2025-03-14T13:20:18Z |
| publishDate | 2019-03-01 |
| publisher | Russian Academy of Sciences, Siberian Branch Publishing House |
| record_format | Article |
| series | Сибирский научный медицинский журнал |
| spelling | doaj.art-e0b18696b9984da9ae8d19877fb503852025-02-28T13:43:53ZrusRussian Academy of Sciences, Siberian Branch Publishing HouseСибирский научный медицинский журнал2410-25122410-25202019-03-01391505710.15372/SSMJ20190107105CLINICAL SIGNIFICANCE OF THE TP53 MUTATION STATUS IN DIFFUSE LARGE B-CELL LYMPHOMAE. N. Voropaeva0T. I. Pospelova1M. I. Voevoda2V. N. Maksimov3Research Institutе of Internal and Preventive Medicine – Branch of Federal Research Center Institute of Cytology and Genetics of SB RASNovosibirsk State Medical University of Minzdrav of RussiaResearch Institutе of Internal and Preventive Medicine – Branch of Federal Research Center Institute of Cytology and Genetics of SB RASResearch Institutе of Internal and Preventive Medicine – Branch of Federal Research Center Institute of Cytology and Genetics of SB RASObjective: to reveal the clinical significance of the mutation status of the TP53 gene in the group of receiving rituximab therapy patients with diffuse large B-cell lymphoma (DLBCL) in Novosibirsk. Material and methods. A total of 74 patients with DLBCL, who have been hospitalized at the City Hematology Center in Novosibirsk for the period 2012–2015, were examined. All patients received therapy with rituximab. The nucleotide sequence of the coding region of the TP53 gene (exons 5–10) and adjacent regions of introns was analyzed by the Sanger direct capillary sequencing. Functional analysis of the revealed mutations was carried out. The results of the patients` therapy were evaluated. Results and discussion. For the first time, it has been revealed in the course of the study of Russian patients with DLBCL setting that TP53 mutation status is associated with the greater incidence of B-symptoms, splenomegaly, leukemia of the lymphoma, and poor prognostic groups according to the International Prognostic Index. A tendency toward a greater frequency of achieving complete clinical and hematologic remission during the therapy was revealed in the subgroup of patients with DLBCL having a canonical sequence of a gene or a mutation in TP53 with an unproven oncogenic potential. Patients with functionally significant TP53 mutations had a lower overall survival rates. Conclusion. For this reason, hopefully therapeutic approaches aimed at the inactivated pathway of TP53 can further improve clinical outcomes in DLBCL.https://sibmed.elpub.ru/jour/article/view/105gene tp53mutationsdiffuse large b-cell lymphomarituximabprognosistarget therapy |
| spellingShingle | E. N. Voropaeva T. I. Pospelova M. I. Voevoda V. N. Maksimov CLINICAL SIGNIFICANCE OF THE TP53 MUTATION STATUS IN DIFFUSE LARGE B-CELL LYMPHOMA Сибирский научный медицинский журнал gene tp53 mutations diffuse large b-cell lymphoma rituximab prognosis target therapy |
| title | CLINICAL SIGNIFICANCE OF THE TP53 MUTATION STATUS IN DIFFUSE LARGE B-CELL LYMPHOMA |
| title_full | CLINICAL SIGNIFICANCE OF THE TP53 MUTATION STATUS IN DIFFUSE LARGE B-CELL LYMPHOMA |
| title_fullStr | CLINICAL SIGNIFICANCE OF THE TP53 MUTATION STATUS IN DIFFUSE LARGE B-CELL LYMPHOMA |
| title_full_unstemmed | CLINICAL SIGNIFICANCE OF THE TP53 MUTATION STATUS IN DIFFUSE LARGE B-CELL LYMPHOMA |
| title_short | CLINICAL SIGNIFICANCE OF THE TP53 MUTATION STATUS IN DIFFUSE LARGE B-CELL LYMPHOMA |
| title_sort | clinical significance of the tp53 mutation status in diffuse large b cell lymphoma |
| topic | gene tp53 mutations diffuse large b-cell lymphoma rituximab prognosis target therapy |
| url | https://sibmed.elpub.ru/jour/article/view/105 |
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